Hep B Blog

There’s Hope for a Hepatitis B Cure at the HEP DART 2015 Conference

IMG_1387This year’s  HEP DART conference brought together liver specialists and researchers from around the world to review and brainstorm about the latest research to find a cure for hepatitis B.

Biopharmaceutical companies presented data that showed their cutting-edge treatments, which use micro-RNAs and other innovative approaches to reduce the virus, appear promising. Much of this research, however, is in early, pre-clinical stages and focuses on laboratory-grown liver cells or laboratory animals, though a few are in Phase I and Phase II trials.

Joan Block, co-founder and executive director of the Hepatitis B Foundation, reported the following news in hepatitis B research from the conference, which was held in Hawaii from Dec. 6-10.

HepDart 2015 marks the 20th anniversary of this conference, and about 600 attendees from 20 countries attended. In opening remarks, Dr. Patrick Marcellin of France noted that the cure for hepatitis C is a huge medical breakthrough, now, he noted we are faced with finding a cure for hepatitis B.

This year’s HepDart meeting included nearly two days devoted to hepatitis B drug development—which shows the new momentum around finding a cure hepatitis B by the scientific community. During previous HepDart meetings, there was almost no discussion about new hepatitis B treatment. But this year, there are more than five companies presenting new hepatitis B drug findings, Block reported.

Researchers at the conference continued to lament the lack of resources spent to research and develop a cure for hepatitis B. They noted the U.S. government has spent $17.5 billion treating HIV. A fraction of that has been spent on finding cures for hepatitis B and C, which infects up to 6 million Americans.

Despite the lack of financial investment in finding a cure, Joan Block reports that the consensus at the conference is that a cure is indeed possible. Despite barriers to achieving a cure because of the complexity of the hepatitis B virus, “the feeling is that there are many targets in the life cycle of the virus and that a combination of a direct-acting antiviral along with an immunomodulator (to boost the immune system) will be the most likely route to success,” she reported.

In the short term, experts may be looking at a “functional” cure. For example, some of the new experimental drugs appear to increase the chances of clearing the hepatitis B surface antigen (HBsAg) with a finite duration of treatment. “Although this wouldn’t take care of (lingering) cccDNA or viral integration into liver cells, it would be a significant advance in treatment,” she said.

Day 2 of HepDart focused on targets within the virus, new therapies and possible cures. Experts explored whether any of the new drugs could produce a functional cure (similar to a resolved hepatitis B infection with loss of surface antigen) versus producing a complete cure that totally eradicates the virus from the liver (including cccDNA). Loss of cccDNA is referred to as the holy grail of the HBV cure.

“The parsing of the word ‘cure’ is frustrating to patient advocates,” she reported, “but the feeling is that the hepatitis B virus life cycle is very complex so an incremental or functional approach might be most feasible.

“Everyone wants a complete cure, including the scientists working on hepatitis B,” she noted, “however, a functional cure might be the most realistic goal in the next 10 years.”

A functional cure means patients will have to take one of the new drugs for only a limited period of time–compared to the current long-term reliance on antivirals that patients take in order to keep their viral loads down and prevent liver damage.

The downside of a functional cure is the potential for reactivation if a person, later in life, needs to take immune-suppressing drugs, such as chemotherapy, to fight cancer. However, this can be managed with antivirals if necessary. This is a similar situation to those who spontaneously recover from an infection.

To underscore the complexity of finding a cure, the image below shows the different targets in the hepatitis B virus life cycle that companies are examining to find a cure.

IMG_1423

There are many promising targets that are being pursued by scientists in academia, NIH, biotech companies and the Hepatitis B Foundation. At this point, the small interfering RNA (siRNA) technology is most advanced. However there are compounds in the pipeline for each category (see below), which is very exciting. Please refer to the Hepatitis B Foundation’s Drug Watch Page for complete list of drugs in development.

“The research work continues,” Joan Block reported, “and there is reason for optimism.”

Dr. Marion Peters - HepDart 2015
Dr. Marion Peters – HepDart 2015

The Hepatitis B Foundation president, Dr. Tim Block chaired a special session at HepDART to discuss what new endpoints will be needed to evaluate the efficacy of the new drugs coming down the pipeline. This will include immunological, virologic, and clinical endpoints for both a functional cure and complete cure.  The clinical endpoint goals might differ based on the phase (immune tolerant, immune active and inactive phase) the patient is in at the time of treatment with these newer agents.

HBF president, Dr. Tim Block
HBF president, Dr. Tim Block

Late breaking update from HepDART!

  • Arrowhead’s hepatitis B surface antigen (HBsAg)-lowering drug (ARC 520) looks promising according to the company’s presentation at HepDart. A single injection of the siRNA first in class type drug lowered HBsAg 10-fold in hepatitis B “e” antigen (HBeAg) positive people. The study was small (a few individuals) but impressive.
  • Arrowhead’s ARC 520 may also be telling us something about chronic HBeAg-positive hepatitis B versus HBeAg-negative hepatitis B. They suggest that the amount of HBsAg in the blood of people with HBeAg-negative hepatitis B may come from “integrated” hepatitis B in the liver, not from “cccDNA.”  This has profound implications for treatment.
  • Novira’s oral drug is a first-in-class capisd inhibitor and was able to lower HBV DNA levels by as much as 100-fold in the small number of people in the initial human trial, according to their presentation at HepDart. Novira was recently acquired by the pharma giant J&J.

“Excitement is really building as the first new hepatitis B drugs come into the clinic,” said Joan Block.

Comments on this blog are closed. If you have questions about hepatitis B or this blog post, please email info@hepb.org or call 215-489-4900.

226 thoughts on “There’s Hope for a Hepatitis B Cure at the HEP DART 2015 Conference”

  1. i have chronic hep B this great news i was searching good news about hepB news everynight when i am prepare to sleep but to night i got good news in my life, i got tested positive this virus 2 years ago and i am still suffaring it, i really wish to get a cure as soon as possible and i thank here to god after all scientist doing great job after 10 years i will 34 not that bad although i wish to cure soon anyway thanks guys one love soon i will be hep free

  2. We hope that once the cure found, it can be reached to all the world including south east Asia regions (that have high prevalence of this disease) instantly with affordable price. May God bless you all and may this research find success very very soon…

    1. Hello: When we lose the hepatitis B “e” antigen (HBeAg) and develop hepatitis B “e” antibodies, it means our immune system is fighting the infection and is slowly developing antibodies to each of the viral proteins or antigens. Being HBeAg-negative usually means our viral load is lower, however the virus is still in our liver and our bodies. Good luck.

  3. This makes me so happy. My mother is a chronic carrier and I am having a baby in January. I want her to live a full life without having to worry about this unfortunate virus…and to enjoy her granddaughter as much as she can. She along with millions of other people deserve it so much. 🙂 Thank you so much for giving us hope.

  4. recently i have digosed hep b positive thanks GOD heared news 100% sucusses full treatment drugs come to market thanks GOD

  5. About two month ago I found out I’m hep b positive
    January 8 I will see specialist I’m not sure if I got it recently or not
    My blood test and ultrasound according to my dr look good
    I hope they come with cure for hep b so we all can live normal happy life..

  6. Thanks God!! with this Godly made doctors, I found hopes in my dreams. Now i can be more positive in looking forward to my disease.

  7. I thank God for the news. It gives me a chronic sufferer of heb some hope. I am praying that medicine for cure will be invented soon and also made available to a place like PNG where I come from.

    Thank you.

  8. Sirs
    Can you explain the difference between e negative cccdna & integrated in the liver with profound implications for treatment & exactly what they mean.

    1. Hello: I’ll give you a broad brushstroke explanation. When the viral genetic material (CCC DNA) inserts itself into our liver cells, it basically hijacks the cells and researchers fear that this integration is what often leads to liver cancer because the viral DNA takes over and produces abnormal cell growth. As researchers hunt for a cure, they know they can reduce the amount of virus in the body, but what they really want is a cure that eradicates the viral CCC DNA that has integrated into the liver cells. So far no one has been able to develop that cure. Thank you.

      1. Hello: Weight loss has not been associated with taking daily antiviral pills, either entecavir or tenofovir. As always, eat healthy foods and of course avoid alcohol and cigarettes. Good luck.

  9. Hi there
    I read that in July 2015 they did a trial here is a paragraph of the script and was just wondering if this is a true story:

    The treatment is a combination of the antiviral drug entecavir and the anti-cancer drug birinapant.
    Researchers at Melbourne’s Walter and Eliza Hall Institute developed the treatment based on their previous research on the behavior of HBV in infected cells. The treatment targets cell signaling pathways that HBV uses to keep host liver cells alive.

    Please get back to me as I can’t find this trial to be in hepb list on your main page.

    Kind Regards
    John

    1. Hello: You may be able to find information on our Drug Watch webpage at http://www.hepb.org/professionals/hbf_drug_watch.htm We report about new hepatitis B drugs in the pipeline if they have reached a stage where they are about to enter clinical trials. The drug combination you are referring to may still be in the early phase of development. We are also watching for new drug developments! Thank you.

  10. please i tested positive for hep b about two years ago that was when i went for a test after years of weight loss. The initial viral load (hbsag) was around 700 miu/ml, it later came to 607 and on ma last test no viral load detected but was still positive and rapid. am gaining weight too. Please can u help me to understand the implication.
    I’m not seeing any doctor

    1. Hello: I can’t comment on your weight loss, are you actively dieting or trying to lose weight? If your weight fluctuates and you don’t know why, you should definitely consult a doctor. You can still test positive for HBsAg and have an undetectable viral load (HBV DNA). It’s very good news, it shows your hepatitis B is “inactive” if it is not rapidly replicating. You also need to check for liver damage, which is tested through a blood test that looks for elevated levels of the liver enzyme ALT (SGPT). Good luck.

  11. Hi
    I was googeling about green tea
    And I saw this :

    Matcha organic green tea more than 3000 good review
    I just wanna know if this good for people with hep b?

    Thanks

    1. Hello: Green tea is healthy, as are many other foods. Surprisingly, coffee appears to protect liver health even more than tea. So keep eating healthy foods. No herb or supplement will cure hepatitis B, but eating and drinking healthy foods will boost your immune system and help protect your liver. Good luck.

      1. Hi

        Thank you for always reply to our msg

        Can u please sujest some healthy food and fruits

        And vegetables is good for liver

        If you don’t mind

        Thanks

        1. Hello: A healthy diet, high in fruits and vegetables with a balance of protein, is a good diet for everyone. There are no special foods recommended for people with hepatitis B, but doctors recommend you stay away from high-fat, high-sugar foods in order to avoid being overweight and “fatty liver” disease. Thank you.

  12. Hello sir I am from India I’m suffering hbsag positive I’m check 4month ago. I have one question hbsag positive convert negative its possible or not, how do start a treatment?… Please reply me sir. Hbsag positive cure or not?… ..

    1. Hello: There is currently no cure that will make the hepatitis B surface antigen (HBsAg) go away, however experts predict in the next few years one will be developed. There are effective antiviral treatments that will lower your viral load (HBV DNA), such as tenofovir or entecavir, but they won’t make HBsAg disappear. Many people live long and healthy lives with hepatitis B, and never need treatment. According to medical guidelines, treatment is needed only if you have a high viral load and signs of liver damage (which is show by elevated liver enzymes such as ALT or SGPT in a blood test.) The best thing to do is eat healthy foods and avoid cigarettes and alcohol. Good luck.

  13. If anyone have hep b and HIV in same time

    Can they live long life ?

    I hope get answer from u

    Thanks

    1. Hello: Yes about 10% of people who are infected with HIV are also infected with hepatitis B. Some of the very effective hepatitis B antiviral treatments actually were originally developed for HIV, and some of them, such as tenofovir (Viread) are effective against both the HIV and hepatitis B virus. Many HBV-HIV coinfected people live long lives with effective treatment. For more information about coinfection, visit http://www.hepb.org/hepb/hbv_hiv_co-infection.htm
      Thank you.

  14. Hello sir,

    My friend from China who is a 26-year old young man was found HBV three years ago, and from then he checked every three month and his condition is stable. However, just half years ago, he started to feel strengthless, frequently have cold and cough, and further result of liver puncture showed that he has earlier cirrhosis. He and his family are excited about the news of hope of HBV cure at the HEP DART 2015 conference and eager to know more details.

    I have several questiones to ask you, first, how long do you estimate the ARC 520 will come on market assuming everything goes smoothly, 5 years? 10 years? second, after ARC 520 and other medicine come on market, will them cure earlier cirrhosis? and do you think earlier cirhosis could be cured? Finally, could you please give some suggestions to my friend about what he should do before these drug come on market, thank you very much!

    1. Hello: It will take several years before there is a cure for hepatitis B, but for updates about new drug developments visit the hepatitis B Drug Watch page at http://www.hepb.org/professionals/hbf_drug_watch.htm
      and for information about clinical trials in the U.S. and around the world, visit our clinical trials page at: http://www.hepb.org/patients/hepatitis_b_clinical_trials.htm
      I am sorry to hear about your friend with cirrhosis. He definitely requires treatment if he has cirrhosis. Medical experts recommend either the antiviral tenofovir (Viread) or the antiviral entecavir (Baraclude.) This will reduce his viral load and hopefully reduce his liver damage.
      We also are optimistic that a cure will be developed soon. Good luck.

  15. I have had Hep B for almost 16 years. I never took any drugs due to costs. In Dec 2014 blood tests showed my body finally attacking the virus, with viral load dropping from 4,555,000 copies to 115,000 copies in 21 months. Liver doc put me on Viread, since I had never taken any other anti-viral drugs. Within 50 days my viral load was down to 20 copies, or basically undetectable. A year later it is still undetectable but I am still E and S surface antigens positive. Viread has been used for 8 years now with continued sustain total viral load as undetectable in trials. But I would love to be able to take something to get me off Viread and all drugs as well. I now have liver cancer and am waiting a transplant in the next few months. Hopefully anti-rejection drugs would still allow me to get a Hep B cure…. Hoping and praying…

    1. Hello: We are sorry to hear about your medical condition and the appearance of liver cancer. We wish you luck with the liver transplant and hope for a cure. Our best.

  16. Am confuse concerning two lab results HBsAg (positive) + and HBeAg – (negative) where does this person find her self? What’s her condition please.

    1. Hello: It is very common to test positive for the hepatitis B surface antigen (HBsAg) and the hepatitis B “e” antibody (HBeAb or anti-HBe). The “e” antigen is present when we have lots of virus in our body that are replicating rapidly. To test positive for the “e” antibody is a good thing, it often indicates that our viral load is lower. Ultimately, we want our immune system to produce antibodies to eradicate or remove each of the hepatitis B antigens. The final antibody that our immune systems produce to completely eradicate hepatitis B is the hepatitis B surface antibody. To determine if the virus is causing liver damage, you need a liver enzyme test (called ALT or SGPT), which is a blood test. Good luck.

  17. Hi dr

    I visit my liver specialist and he told me my viral load it’s
    8669 but he said I don’t need to take any medication because it’s not
    So high

    They did blood test , ALT/AST test all good
    Fibroscane was good
    Ultrasound was good

    So I’m kinda worry wouldn’t be bad to not take any
    Medication now ? I’m worried might be to late later on..

    What u think about my situation

    According to my dr I have hep b for while..

    1. Hello: As we’ve indicated in the past, your doctor is correct. Unless you have signs of liver damage and a high viral load, you do not need treatment at this time. Good luck.

  18. Pretty nice post. I just stumbled upon your weblog and wished
    to say that I have really enjoyed surfing around your blog posts.
    In any case I will be subscribing to your feed and I hope you write
    again very soon!

  19. I have four brothers died from Hep B. I think the virus is stock in our blood. I really do not know how we got it and it is very sad. All of my brothers died while very young. I started taking treatment in 2005 and I’ve been constantly checking this website for Hep B news and treatments. I’ve been praying so that God could show his doctors about finding the treatment for Hep B. I am very thankful and to see that doctors are now finding the treatment. We really need the medicine to eradicate this silent killer virus. Thank God. I’ve been on Viread for 6 years now. Is there any latest medicine other than the viread? Is it possible to know when the medication for Hep B will come out?

    1. Hello: Viread (generic name is tenofovir) is actually the best and most potent antiviral available. It is highly recommended because it does not cause any drug resistance, and research has shown patients have taken it for several years safely. You are doing the best you can. We are all hopeful that a cure will be developed in the next few years. Good luck.

    2. Check for enyo pharma’s new cure compound for hep b, tetra logic pharmaceutical new cure and ABX203 which are all coming out later this year or next year.

  20. Sir i told you about my wife’ that she is hbsag positive in her test .in which category i include that in acute or chronic.
    On more thing she is 27 now and what is life expentacy of hep b chronic patients.
    Thanks in advance.

    1. Hello: To clarify, a person is considered to have chronic hepatitis B if they test positive for the virus (the hepatitis B surface antigen or HBsAg) for six months or longer.
      Many people live long and healthy lives with hepatitis B and never need treatment. If your wife takes good care of her health and does not smoke or drink alcohol, she may have a very long and healthy life. Good luck.

  21. This is so great news and high hopes for Hep-b patients. I would like to congratulate to the org and scientist.
    I’m suffering hep b since last 10 years and thanks God last six years on Tenofovier the God’s given another life for me! But unfortunately That tablet makeing me suffer bone loss and my I’m bit worried but still thanks I’m live.
    I never had so much will for not to die since my 4 years hug and kiss me and says “papa I love you, good night see you tomorrow”
    I am so worried for his pain than i die..he think i’m his mother i’m his father i’m his best friend and God forgive me- he tjinks im his God!
    If one day he sees none of this im sure it will not easy for that litle innocent life.. And thats the reason im so happy to see this news.
    I wish you success to this reaearch.
    Many thanks

    1. Thank you, it sounds like you are a wonderful parent and I’m glad tenofovir is working for you. We also hope a cure will happen soon and we are doing our best to make that happen. Good luck to you and your family.

  22. I’m 30 years of age and I have been tested positive of hep b about three months ago. How ever I have been suffering frm chest pain for about 3 year and i still suffring from that. Is it because of my hep that is causing me that. Thank you Drs fot your titedless effort to fight this disease, albert form Ghana.

    1. Hello: A new diagnosis of hepatitis B can certainly cause stress and can worsen any pre-existing medical conditions. I encourage you to see your doctor and explain any changes in your health, especially if your chest pains are becoming more frequent or painful. Good luck.

  23. I am a 27 year old man. I had hep B test before 8 month ago and have hBv in my blood.the doctor said my liver is on cirrhosis stage.I take tenofovir the last 5 months&the viral load is undetectable he said& a month ago I had fibroscan examination,the image shows my liver is on 4th stage so am very worried right now.so how long live after this please.am waiting my specialist appointments for asking this question.thank you very much you guys will searching the cured medication.sorry for my english.

    1. Hello: I am very glad you saw a doctor and that he prescribed tenofovir, given the liver damage you have, and I’m happy to hear the antiviral was able to reduce your viral load to an undetectable level. Your specialist will probably want to monitor your liver enzymes, which indicate liver damage, and run other tests every three months to monitor your infection. I also suspect he may continue your antiviral treatment because of your condition. Make sure you are also screened for liver cancer (this includes liver imaging and a blood test for alpha fetoprotein) regularly. Good luck.

  24. Thank you for your hardwork. Is it possible for a chronic Hbv patient to completely eradicate the virus with time and become free

    1. Hello: It reportedly occurs in about 1% of people with chronic hepatitis B, usually after long periods of testing negative for the hepatitis B surface antigen (HBsAg) and having undetectable viral load. We all hope for this. Good look!

  25. In your opinion, how does ARC 520 compare to other HBV drugs available or in developement e.g. ABI VAX(now available in Cuba), ABUS or any others that you are aware of? Which of these drugs is likely to become available first and when?

  26. Hello
    My fried. have found to be Heb B positive by accident when Visited the doctor for another reason.He is HBS Antigen positive witn E amtigen negative and the viral load is undetectable for the last 15 yrs when He was first found to be positive.
    What is the risk of transmitting the disease to other people through sex? If the partner is immunised is there any risk of getting the virus? Is there any risk of transmitting the virus to their baby if partner get pregnant ? Which antiviral is most effective in clearing surface antigen completlt ?
    Thank you

    1. Hello: As long as someone tests positive for the hepatitis B surface antigen (HBsAg), they can transmit the infection through sex. However, if their partner has been immunized against hepatitis B, and has enough hepatitis B surface antibodies to protect them (at least 10 mIU/mL) then they can safely have unprotected sex. The baby must be immunized with the first hepatitis B dose within 12 hours of birth to be protected against infection. Good luck.

  27. You Encouraged me really when I read this delighting news. It opened for me a new window of Hope of life.
    Thank you those who are working hard to find a cure for this fital virus.
    I am HBV carrier and I take Lamivudine tablets everyday.
    If there is an other more effective antiviral drug than Lamivudine, please give me some advice.

    1. Hello: Lamivudine was one of the first antivirals developed to fight hepatitis B, but it has a high risk of causing drug resistance. When this happens the virus “mutates” and is able to replicate despite the presence of the virus. However, if lamivudine is working for you now, and it is the only available antiviral for you, then continue to take it. Currently, doctors recommend either tenofovir (Viread) or entecavir (Baraclude) as the top two best antivirals because they are potent and have low rates of drugs resistance. Good luck.

  28. Hi.. What is the safest medecine for HBV that is available now in drugstores? Those aproved by fda.. Tnx.. Im thinking for viread..

  29. Hi,
    I’m male, 38YO. I’ve been dignosed with Chronic Hep B almost a year now. Hbeag (-ve), V.Load – Unknown, FibroScan – 11.4kpl, ALT – fluctuate 30+ – 60+ (within 1 year). Before, i was also dignosed with hypothyroid taking thyroxine 75mg/daily. I did HBV profile bloodtest 3 times, all HBV reactive. But recently the doc said that since i have hypothyroidsm (autoimmune diesese), i might have the autoimmune hepatitis, not chronic hep b. Is it possible that i’ve been misdignosed of different type of hepatitis?..
    TQ.

    1. Hello: How your body responds to an infection determines whether you have an auto-immune disease. Autoimmune hepatitis is liver inflammation that occurs when your body’s immune system turns against liver cells. The exact cause of autoimmune hepatitis is unclear, but genetic and environmental factors appear to interact over time in triggering the disease. The underlying infection, which is triggering this autoimmune response in you, is hepatitis B. As long as your lab tests identify the hepatitis B virus in your blood, hepatitis B is present. Good luck.

  30. Hi!!..
    I am men,32 years of age, and I don’t know when was hep b started,I only know that i have hep b when going to apply to job actually we have 4 friends same cases of mind and still losing our hope to find cure thats why we didn’t go to doctor’s but my last check the doctor was 3 years ago and said the my kidney and liver were already clear but know through you news our hope become alive., we hope through you expert or scientist will have totally discovered the cure of hep b.,Please give me feedback regarding on this.thank you.

    1. Hello: Scientists expect to find a cure for hepatitis B in the next few years. It is important to get monitored for liver damage, because there are effective treatments to lower your viral load (HBV DNA) if you ever need treatment. In the meantime, we recommend that you eat healthy food, and avoid cigarettes and alcohol. And don’t forget to practice safe sex (use a condom). Good luck.

  31. Hi
    Im “inactive” Hbv carrier with “Hbe Ag Negative”. Is Arc 520 also designed for “inactive” hbv carriers with Hbe Ag negative??? Thank you so much

    1. Hello: When a new drug is being developed, the experts tend to target specific patient groups to test out the drug’s effectiveness and safety. With each new clinical trial, they will refine which people they will try the drug out on. I don’t know if they’ll start with patients who are HBeAg-positive or negative. Keep visiting our drugs in development page at http://www.hepb.org/professionals/hbf_drug_watch.htm and also our clinical trials page at http://www.hepb.org/patients/hepatitis_b_clinical_trials.htm for new information about this and other drugs in development. Thank you.

  32. I’m a medical student, I’m a victim of hepatitis b with high amount of virus DNA. I feel fatigue and pain in muscles everyday. My life is completely dark because of it. Hope your work get success and wish u all good luck 🙂

    1. Hello: Are your ALT/SGPT levels normal? If this blood test shows above normal ALT levels (normal is 30 or less for men and 19 or less for women) then you may need treatment if your viral load is also high. Otherwise, your fatigue and muscle pain may be caused by something else. Please consult withy your physician. Good luck.

    1. Hello: I understand, we still don’t know whether ARC will prove effective, nor do we know which hepatitis B patients will be asked to participate in clinical trials first. Good luck.

  33. Hi
    Thank God for good news…Do you think after pruduction Arc520, it will be useful for inactive Hbv Carriers? 

  34. Hi Dr

    I saw my result

    My second ultrasound was good no sign of anything

    And my hep B level from 8669 goes down to 2345
    With out taking any medication

    I’m just eating healthy lots water , coffee and excercise

    Is this possible ur viral load goes down because of those I mention

    I feel a lot better my load going down
    What u think

    Thanks Dr

    1. Hello: I’m glad your reports are good! A healthy body and immune system are certainly able to suppress the infection and stop the virus from replicating far better than an unhealthy one! Keep exercising and eating healthy food! Good luck.

  35. Hi,I have been following Hep b medical information for years as a patient for life. I am a 59years old Asian female. I have been taking two medicines for years after one of my medicine stopped working. Now I am worry about possible kidney damage from taking so long these medicines and also worry about bone loss. My liver doctor said I am doing fine as long as low virus. What about the side effect? Kidney damage is also bad as liver . I just hope Australian doctors develop the cure for Hep B near future. My half of my family members died from liver disease early ages. And I saw how much they suffered from pain until they died. I also passed this virus to my son who is 32 years old which I carry a huge guilt all of my life. I hope I can see the cure near future from Australian doctors who are working hard on Hep B cure.

    1. Hello: I assume you are taking antivirals to keep your viral load down. It is true that some antivirals cause bone loss and can affect your kidneys. It is important that your doctor monitor your kidney function regularly, and also test your vitamin D and phosphorus levels annually and perform a bone scan every three years.
      The antiviral entecavir (brand name Baraclude) does not cause bone loss, however tenofovir (Viread) does cause it in a very small percentage of people. Our hepatitis B experts recommend that you should talk to your doctor about taking 1,200 mg of calcium per day and keeping your vitamin D levels (identified by a blood test) in the 40-50 range. Also, ask about bone scans to watch for any bone loss. Good luck.

  36. Hi,
    I’m a carrier ofchronic hepatitis B. I came to know about this when i was going through the final medical check up to join Bangladesh Army. Unfortunately, they rejected me because of hep B. However, i’m taking medication & is under the surveillance of a specialist.

    I need to know that i’m a Civil Engineering graduate now and want to pursue my higher studies from the countries like USA, Australia, Canada or any European Countries and have the mind set to settle there. In this connection, can you please provide me with some exact information regarding the chances of getting visas to these countries being a carrier of chronic hepatitis B?

    I need to know this very badly. I tried to find some information from different sources but most of them are confusing.

    Thanks in advance & look forward to hearing from you soon.

    1. Hello: I am sorry to hear about the discrimination you faced in your home country. Unfortunately, some countries in Central Asia and the Middle East allow employment discrimination based on hepatitis B, though there is no scientific basis for this. While some countries may ask about your general health, no countries in North America and Europe will restrict your employment in those countries based on your hepatitis B status. Countries will simply want to know that you are healthy and able to perform the job. Good luck.

    1. Hello: There have been NO documented cases of hepatitis B infection transmitted by a mosquito. Mosquitos can transmit certain diseases, such as malaria and zika, but not hepatitis B. Thank you.

  37. Hi there,
    Im so ecxited to hear about that news but i have a question
    Is Hbs Ag loss in functional cure? is Functional cure meaning is you get heald like acute hepatits b with loss Hbs Ag??

    1. Hello: Some people with chronic hepatitis B (which lasts longer than six months) lose the hepatitis B surface antigen (HBsAg) on their own. I believe the article was exploring if new cures would simply reduce HBsAg to undetectable levels, or would it be able to totally get rid of all hepatitis B virus in your liver and result in appearance of hepatitis B surface antibodies. Good luck.

  38. Thank you for such a great news, I am living with this virus for 4 years, but still I am alive, I have Hb positive, but according to the doctor it is silent in my blood no need for treatment , So I am just worried I would like to go to USA or other countries for continuation my higher education , but as I hear from people they are not giving the visa for people with HB positive. I would like hear from you is there such a limitation for people having positive HB !?

    Looking forward for your response

    1. Hello: You should have no problem getting a student visa in the U.S., Canada, and many European countries. Unfortunately, some countries in the Middle East and Central Asia discriminate against people with hepatitis B and will not issue any visas to study in or work in their countries. It is an unfortunate occurrence that we hope will change soon. Good luck.

  39. Hi,God bless you….
    In clinical trial Arc 520 is in phase 2 study,You think you know when to begin Phase 3 studies???

  40. Hi really I want to admire your clear explantion for each question!
    I am 34 years old and I have chronic hb and the hbeag is negative alt changes from 45-64 in one year the viral liad is 9000unit/ml my dr.advised me to start taking vireal and am worried to start should I start ?

    1. Hello: Only your doctor knows you and your history and can make that decision. Your viral load is slightly elevated for someone with HBeAg-negative hepatitis B, and your ALT level, which indicates liver damage, is also slightly elevated. Normal ALT levels for men is 30 and under and for women it is 19 and under. Tenofovir (Viread) is one of the top two recommended hepatitis B antivirals. What you have described matches current medical treatment guidelines. Good luck.

  41. Hello! this is great news and 10 years seems a lot but we have faith it comes sooner! I had a exposure situation and I am really scared. I went to my Dr and asked me to take some blood samples after 4 weeks. I am praying for you scientists on treatment and a cure for all the patients suffering from this, I really had no idea how serious this is, we need to inform everyone to get vaccine.

    I have a couple questions on transmission. While cleaning a public bathroom I got splashed in the eye with urine that was absorbed by a humid broom. Should I consider this a risk? Also, Is it a risk if we are using a public toilet (to poo for example) and some water/urine mix splashes into the anus? I frequently have issues like this on my mind, or if someone is talking to me and spits tiny particles on my eyes? Should I worry on this situations?

    Thank you very much!

    1. Hello: Urine and feces do not transmit hepatitis B, and it is unlikely you will become infected if water from a toilet splashes on you. Saliva also does not transmit hepatitis B, unless the person has bleeding gums or sores around their mouth. To make sure you do not become infected, the best thing to do is get immunized with the safe and effective hepatitis B vaccine. Good luck.

      1. Thank you very much for the quick reply to my question. You gave me a lot of peace. According to your comments I read that I was not at risk and my test results came all negative at 4 weeks. Do you think I should test again at 9 weeks or this can be conclusive given the small risks?
        Thank you very much for all the work you are doing, people really need it. This is a life changing for me. God bless all of you!

        1. Hello: Talk to your doctor, but if you were tested four weeks after possible exposure, it might be wise to be retested as an infection may not be detected by a lab test until nine weeks or long following exposure. It can take several weeks for the viral antigens to multiply enough to be identified by a lab test. Good luck.

  42. Hi,
    Thanx for good news and Answer quickly!
    Is that possible inactive hbv carriers in that state (normal Alt&Ast, hbe ag-,hbe ab+,undatectable HBV DNA) suddenly whit normal Alt&ast HCC found?? Sorry for my english, but please answer to me. If it is possible how much percent??

    1. Hello: If you have normal ALT and undetectable viral load, your risk of liver cancer is very low. What causes liver cancer over time is continued liver damage and elevated viral load (HBV DNA). Keep getting monitored, however, and remember to eat healthy foods, and avoid alcohol and cigarettes. Good luck.

  43. Hi…..tenofovir is approved in the year 2008..after that no cure has been discovered as of now….it has gone more then 8 years….why so?

    1. Hello: Researchers are focusing on brand new treatment approaches that require new technology and expertise and time. We anxiously hope for their success. Thank you.

    1. Hello: When liver cells are damaged, they release the enzyme ALT (also called SGPT) into the bloodstream. Normal ALT levels are 30 and less for men and 19 or less for women. However, some labs have different ranges for “healthy” ALT levels, so you need to see what you lab identifies as normal. Some indicate that up to 50 is still healthy. Medical guidelines recommend treatment only if you have signs of liver damage AND elevated viral load. Please talk to your doctor about whether treatment is needed. If you live outside the U.S., you can find World Health Organization hepatitis B treatment guidelines at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
      Thank you.

  44. I have HBV…..HBsAg postive
    HBeAg negative
    HBe Ab postive
    HBc Ab total postive

    HBV PCR by DNA 193 iu/ml
    Normal ALT.AST

    I was diagnosed as inactive carrier
    I would like to ask if i take corticosteriod dexamesathone can correlate with HBVmarkers in the lab anaylsis….or how i can hide the surface antigen HBsAg temporary from the blood without any harm to my liver?

    Another question shall i take entecavir drug or not?
    All drs told me not to take drugs as guidlines protocol….if i take will harm me

    Thanks inadvance

    1. Hello: There is no medication that will “hide” the hepatitis B surface antigen (HBsAg). Also, antivirals such as entecavir, will reduce the amount of virus (HBV DNA) in your blood, but not necessarily reduce HBsAg levels.
      If you have normal ALT levels, which you do, and low viral load, you do not require treatment. You are healthy and need no treatment. Good luck.

  45. Hi Dr.

    This good news for HBV carries, i read through on website that in phillipina, new treatment is found under name of chelation therapy,1. is it true?2. does this method can completely cure a patient from hbv? my ALT/AST are around 35 -40 over eight years, DNA was not detected in first test, Hb e antigen negative and Ab e is positive right now, my doctor do not presccibed DNA again and never treatmen. 3. i am still inactive?

    1. Hello: Currently, there is no complete cure for hepatitis B. There are antiviral treatments that reduce viral load and the risk of liver damage and cancer, but there is no complete cure. Your doctor knows best about how frequently to test for viral load, especially if it is an expensive test. They key thing to do is to continue to test your ALT levels to make sure your hepatitis B remains “inactive” and there is no liver damage. Good luck.

  46. Am living in south Africa, can I know how far is abx203 and taf to the market. When can we buy and use them.

  47. As going through the update from hepbdurt conference. …the upcoming medicine like ARC 520 …which was supposed to update the llnd clinical trial reasult…and when r you all planing for lll clinical trial for ARC520…and how long ir takes to come in market. …

  48. I am a patient of carrier hepatits b sence last 18 years. My report is hbeag : negative, anti HCV :negative , HBV DNA viral load :12500 IU/ml. ,LFT :normal range (shpt:40),fibroscan :mild fatty liver.my questions is
    1)I am inactive carrier ?
    2)can new medicine cure HBV totally ?
    3) how long the medicine available in India market ?
    Thanks

    1. Hello: Because your viral load is detectable and elevated for someone with HBeAg-negative hepatitis B, you are not an inactive carrier. Normal ALT (also called SGPT) is 30 and under for men and 19 and under for women, so your ALT levels are slightly elevated. HBeAg-negative hepatitis B occurs when the virus mutates and is able to reproduce without producing the hepatitis B “e” antigen (HBeAg). It occurs in people who are HBeAg-negative, have viral loads over 2,000 IU/mL and have elevated ALT/SGPT levels, which indicates some liver damage. At this point, depending on your age, gender and overall health, your doctor may even recommend you get treatment to reduce your viral load. The top two leading antivirals, which I believe are both available in India, are tenofovir (Viread) and entecavir, which reduce viral load and reduce the risk of liver damage.
      There is no complete cure for hepatitis B at thsi time, however researchers predict a cure will be developed in the next few years, so we are very optimistic. Thank you.

      1. Sir ,
        Now I am 29 year’s old.sence last 18 Years of my carrier stage I do not use any medicine.And I do not fill any symptoms right now. My sgpt:38 (lab reference <40 for men ) .Is this high ? In this stage can I require any treatment for reduce viral load ?(12500 IU/ml by TAQ MAN)

        1. Hello: While medical guidelines state that an ALT level of 30 or less is healthy for men, every individual lab has its own “healthy” range that in your case goes up to 40 for men. There are sometimes variations between labs based on the equipment they use. We recommend that you use the same lab so you have true apples-to-apples comparison.
          Your viral load is not very high, and because your SGPT levels are healthy, you do not need treatment at this time. It is important to discuss that with your doctor. Good luck.

  49. Hi Dr,I have a question
    As you know some inactive carrier have HBv DNA between 2000-20000 with permanent normal Alt level. If some inactive carrier (they confirmed as inactive carrier) have HBV DNA a little above 2000 with normal Alt, do they need treatment??

    1. Hello: Medical guidelines recommend treatment if your ALT levels are high, indicating liver damage, and your viral load is high. If your ALT is normal, generally doctors do not recommend treatment, but it’s important to talk to your doctor about that. Good luck.

  50. Hi, I am 35 years old, 8 years back I had a Hiptitas test. In which HbV was postive. I have visited to doctor he advised me to check regularly your LFTs, ALT and PCR for viral load. In the beginning the viral load were 6556 but with the passage of time it reduced without any treatment. at present the latest PCR report shows that Negative control NTC not detected, Low positive control Within range and high positive Control within range. and Sample shows viral load to 444 IU/ml. My doctor still not asking for any medication. is it ok or should i take the medication?? to avoid liver damge

    1. Hello: If your liver function tests (particularly the ALT or SGPT test) are normal, and your viral load remains low, you do not require any treatment. To avoid liver damage, continue to be monitored regularly, eat healthy food, and avoid alcohol and cigarettes. Good luck.

  51. Sir,
    I was diagnosed as Hbsag +ve since 2 years back and i have started medication as advised by doctor. Initially, i was given entecavir for 9 months and later doctor changed the medicine to tenofovir. And currently I am taking tenofovir for 15 month.

    During the course of treatment my USG reports are normal but my LFT especially ALT fluctuates up and down. Sometimes it stays within the range and sometime it shoots up above the max range. Today my ALT is 64 which i believe is quite high.

    Initially my viral load was 95488730 iu/ml and my next test is ll be done in next month,
    I have a couple of questions that I require your clarification as follows:

    1. Does change in medicine from entecavir to tenofovir affects the viral resistance of medicine? If it does, what should be the next thing to do?
    2. Is it normal or abnormal to have changes in ALT level up and down during the course of medication? Or shouldn’t it be consistently decreasing the ALT level and maintaining it within the range?
    3. How far stress will affect the ALT level?
    4. Can one survive 70’s if he/she has infected from birth and has maintained normal USG and LFT with undectable or very low viral load.

    Thanks in advance

    1. Hello: Your ALT level – 64 – is actually not that high. Each lab’s “healthy” range for ALT is different, and some consider up to 50 or under to be normal. Now for answers:
      1. Does change in medicine from entecavir to tenofovir affects the viral resistance of medicine? If it does, what should be the next thing to do? If entecavir is not working to reduce your viral load, it may mean that your hepatitis B virus has a mutation. In that case, medical guidelines recommend doctors use tenofovir. Tenofovir is very effective even against hepatitis B that does not respond well to entecavir. Hopefully with tenofovir your viral load and ALT will decrease.
      2. Is it normal or abnormal to have changes in ALT level up and down during the course of medication? Or shouldn’t it be consistently decreasing the ALT level and maintaining it within the range? If you didn’t respond well to entecavir, it is not uncommon to have your ALT and viral load remain a bit elevated. Tenofovir will eventually bring down your ALT.
      3. How far stress will affect the ALT level? ALT levels increase with stress or illness/medical conditions that are unrelated to hepatitis B. So if you’re sick from the flu or under stress, your ALT may increase.
      4. Can one survive 70’s if he/she has infected from birth and has maintained normal USG and LFT with undectable or very low viral load? Yes, many people live long and healthy lives with hepatitis B. It sounds like you are getting monitored regularly, which is important. Keep eating healthy food and avoid alcohol and cigarettes! Good luck.

  52. Thanks for such a wonderful blog . Am optimistic about the scientific research. May God grant you favour. it will be of great help to all of us.

  53. Hi sir,
    I diagnosis as a inactive hbv carrier since 16 years ago. 2 years ago i had a hive for 4 mounth and then i get heald from hives. My ast/alt was normal during the hives and still normal yet. Now i dont have any hives and my alt/ast is normal, do you think there is an assosiation between hives and hep B??

    1. Hello: I am unaware of any allergic reaction related directly to hepatitis B that would cause hives. Continue to have your hepatitis B monitored, as you are doing. If you experience hives again, see if there is a change in diet or environment or stress that could contribute to them. Good luck.

  54. Respected sir, i am infected with Hbv. when i went for viral load test it is 336mui/ml six eight months back . today it is 2064 mui/ml. sir, the virus is incresing in my body. liver function test is normal. i am married one year back. as soon i came to know my infection .i vaccinated my wife. her hbs ab is 550 mui/ml. can we try for children?
    sir, am i chronically infected. please help me

    1. Hello: As long as your wife’s hepatitis B surface antibody is above 10 mIU/ml, which at 550 it certainly is, you can safely have unprotected sex without infecting her.
      Our viral load (HBV DNA) can fluctuate over time, and your increase is not dramatic. Continue to get monitored regularly, whatever time period your doctor recommends, and make sure your liver enzymes (ALT or SGPT) are also tested. Good luck!

  55. Hi Dr,
    I got married 5 years ago and my husband is inactive hbv carrier and i knew it. I knocked vaccine 5 years ago and my anti body was 150. Now after 5 year i am pragnent but now when i cheked my anti body, it was 9!!(under 10)
    Dr, my baby will coming in next 3 week and im scared. Is that possible i infected with hbv but my hbs ag is still negative for now? And my baby get patient? Please please dear Dr help me im scared what should i do???

    1. Hello: It is not uncommon for hepatitis B surface antibodies to decline over time after vaccination. Even though our antibodies may fall below 10 mIU/mL, doctors believe our immune systems are still able to fight infection. Because you test negative for the hepatitis B surface antigen, you should be fine. However, it is important to make sure your baby is immediately vaccinated against hepatitis B within 12 hours of birth, that way you can be sure he or she is safe. We wish you good luck.

  56. Hello dear, I tested positive for hepatitis b. Its been 8months now. My physician said the test result shows the liver is normal comparing from the initial test and it could be possible my body kicking off the virus. Is it possible for the virus to be removed after it has passed the acute stage? Is there any news on the possible cure?

    1. Hello: Sometimes it may take longer than six or eight months for our immune system to clear the virus if we’re infected as healthy adults. However, if you were infected at birth or when you were young, you may have developed a long-term or chronic infection. Keep up the monitoring and consulting with your doctor. It’s good news that you have experienced no liver damage.
      Experts predict there should be a cure in the next few years. We and the scientific community remain optimistic. Good luck.

    1. Hello: Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets (at https://nccih.nih.gov/health/herbsataglance.htm) are so valuable.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver. Good luck.

  57. Hi, unfortunately I have chronic hepatitis B, stage 1 on first biopsy and stage 3 on 2nd biopsy. This horrible demonic illness has rendered me bed ridden. I have several diagnosis…if cause of hep B…PKD, RSD II, 45 mixed apneas a night with up to 45 sec., severe dysphasia, etc. I’m blessed to still have my brain…good and bad days, severe weight loss, I am 5’10 98lbs. Hoped this info helped to know if your ALT/AST can top out after years of being 600-800. Viral load is extremely high, but don’t know how to equate it out. I’m HBsAg positive, I was told I have a precore mutation. I’ve not sero converted. I was on hospice, but go taken off after a 5 min eval from a doc I don’t know. I’ve been seeing my doc for 9 years and pain management 9 years. He said based his decision on CBC/DIFF and I’m not swollen in belly or orange. Please help. Desperate. I keep telling my husband I’m going to suffer until my last breath.

    1. Hello: If you have any kind of hepatitis B virus mutation (such as precore), the antiviral tenofovir (brand name Viread) can reduce viral replication. Please talk to your doctor about using an antiviral to bring down your viral load, especially if you have liver damage. Good luck.

      1. Thank you for response. Being as sick as I am, 98lbs< @5'10 and being severely malnourished, still HBsAg, never sero-converted and with precore mutation. Interferon, Tenofovir, Baraclude is recommended, but doctor called said viral load so high, recommended I start in the ICU. I've missed my last 2 biopsy for what is he point if there's no cure and my declining health. Please help

        1. Hello: Follow your doctor’s recommendations and begin an antiviral immediately to lower your viral load. Good luck.

          1. Pls can I know exactly how many years can it take to get the cure?.
            So I can be happy once more in my life please doc.
            Hope to read back from you asap.

          2. Hello: Do not let your hepatitis B define whether you are happy or not. Many people live long and healthy lives with hepatitis B. It is important to eat healthy foods, and avoid alcohol and cigarettes. In the meantime, experts predict a cure will be developed in the next few years. We are optimistic, please do not lose hope. Good luck.

  58. Hi Sir,

    Gilead’s TAF is designed to be a functional cure? And when will it be ready?
    When will Arrowhead’s ARC 520 be ready in the market?
    And what is the status of ABX 203?

    I hopping all these drugs as I am hepatitis b carrier.

    Thanks you so much

  59. Hi, could you tell me how much cup of coffee should I have to take per day to protect my liver according to research findings.
    I am a hepatitis b carrier under Baraclude 0.5 mg
    Thanks

    1. Hello: Some studies show that about two cups of coffee appears to confer some protection to your liver. Don’t overdo it! But coffee in moderation appears healthy. Good luck.

  60. Hi. Can TAF for hepatitis B be a functional cure to hepatitis B and when can it be available in South Africa.

    1. Hello: TAF is the abbreviation for the antiviral tenofovir (brand name Viread), which is one of two antivirals recommended for hepatitis B treatment. It should be available in South Africa, you should ask your doctor or see a provider at a major hospital or go to a clinic at a medical school.
      It is not a “functional” cure, however, over prolonged treatment in a small percentage of people it does eradicate hepatitis B and result in clearance of the hepatitis B surface antigen (HBsAg), viral load, and achieve normal liver enzymes (ALT/SGPT). Good luck.

  61. respectedsir
    iam from india , yesturday on 8/06/ 2016 my dad got checked before eye surgery with suprisingly he got HBsAg we total breakdown hearing this already my dad is suffering daibetis and blood pressure my dad age 49 we dont know what to do how to face these problem .i have some question for you sir
    1.what is this disease? how it willl get ? how it effects?
    2.Is this curable ?
    3 .finally what i have to do to save my father life please give me guide reply me sir

    1. Hello: I am sorry to hear about your father. Please visit http://www.hepb.org to learn more about hepatitis B. What is important is for your father to have his liver enzymes (called ALT or SGPT) check to see if he has experienced any liver damage from hepatitis B. This is a simple blood test. He should also get an ultrasound and be monitored regularly. While there is no cure for hepatitis B, there are very effective antiviral treatments (with either tenofovir (Viread) or entecavir) that quickly lower viral load (the amount of virus in his blood) and reduce the risk of liver damage.
      What also needs to happen is that your mother and siblings also need to be tested for hepatitis B. As you may know, hepatitis B is transmitted by exposure to infectious blood and body fluids, especially sexually or during birth.
      Having these tests performed will give you a sense of how your father is doing, and there is effective treatment should he need it.
      Experts hope to develop a cure in the next few years, so there is good news on the horizon. Good luck.

  62. I ran across your website and wanted to say God bless you for what you are doing for the Hep B community! I am desperately searching for answers to my problem and I can’t seem so find it anywhere so far.
    I was exposed to Hep B 10 years ago and did not realize it till I got extremely sick after a flu shot 8 months ago. I do not have any detectable virus in my blood and viral load is undetectable. My Dr said I am an inactive carrier. However, for 8 months now I have had so many crazy symptoms and I thought I was gonna die for the first 5 months after my flu shot. I had persistent fatigue, skin feels itchy, tingling in my body, bad pain in liver area and other symptoms. I went to ER about a month ago and my Liver enzymes were elevated (63). Throughout the months I have watched my liver enzymes go from 19 to 63 but my Hep B tests are all undetectable. The only thing out of range is core antibody (surface antibody not present). I stay fatigue, skin burns sometimes and my liver area has pain. Is it possible the virus is embedded in my liver and hurting it while every HVB test is undetectable? I’ve always been an extremely healthy person and to me this could only be caused by hep b 🙁

    1. Hello: I just want to confirm, do you currently test positive for the hepatitis B surface antigen (HBsAg)? This confirms that you are currently infected with hepatitis B. Usually, hepatitis B is a “silent” infection that rarely causes abdominal pain or prolonged fatigue. For a complete description of symptoms, please visit: http://www.hepb.org/what-is-hepatitis-b/what-is-hepb/symptoms/
      There are a number of reasons why ALT levels can climb, in addition to active hepatitis B. They increase as a result from other illnesses, drinking alcohol, exposure to certain toxins, and even taking certain medications. I encourage you to talk to your doctor to see if you are experiencing another medical condition, not related to hepatitis B, that is causing these symptoms.
      Here is another resource about abdominal pain and hepatitis B: https://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/
      Good luck.

  63. I do not have active hepatitis b. I was told it is dormant in my liver. My curiosity is if hep b can clear your books stream altogether but still be hanging out in the liver causing damaged liver cells and eventually liver cancer? I have looked up hep b symptoms and I have had all of them at some point recently but still undetectable after exposure 10 years ago. 10 years ago I suffered an extreme sickness after I was exposed to hep b and mono at one time. Both viruses are inactive. I have felt good for 9 years now until the flu shot. It has been 8 months and still do not feel completely well 🙁

    1. Hello: As long as you test positive for the hepatitis B surface antigen (HBsAg) and don’t have the hepatitis B surface antibody, there are hepatitis B virus in your liver, even if the infection is “inactive” and not causing any liver damage at the moment. It is important to continue to be monitored for hepatitis B and liver damage, even if your infection is considered inactive.
      You are correct that you never completely get rid of the hepatitis B virus, even after you develop surface antibodies. Like chicken pox, small amounts of the virus remain in the liver and can reactivate if your immune system is weakened by other illnesses, medications or toxins.
      The coinfection with hepatitis B and mono no doubt stressed your immune system. Please continue to see your doctor and review your symptoms and get monitored in order to safeguard your health, and avoid alcohol and cigarettes.
      Good luck.

  64. My Hep B antigen is negative. Here are my results below…
    Hep Bs Antibody (negative)
    Hep B surface antigen (negative)
    Hep B Core Antibody Igm (negative)
    Hep B surface antibody (negative)
    Hep Be Antibody serum (negative)
    Hep Be Antigen serum (negative)
    Hep B DNA quantitive (undetected)
    Anti HB Core AG IgG and Igm total (out of range)

    1. Hello: If I understand your lab results correctly, you are not infected with hepatitis B, nor have you been in the past. I recommend you get immunized against hepatitis B as soon as possible to safeguard yourself from infection. Good luck.

  65. The only thing that was positive was Anti HB Core IgM. Liver Dr at Mayo clinic said I have Hepatis but my immune system has contained it. If that is true I don’t know why my liver enzymes were elevated when I’m not on meds, drink alcohol or anything. I’ve been having really bad pains under my rib cage 🙁

    1. Hello: When you test positive for the hepatitis B core antibody (anti HB core) it means that in the past you were infected with hepatitis B. However, your test results show your immune system has cleared the infection and you have tested positive for hepatitis B surface antibodies.
      Please talk to your doctor about the pain under your rib cage, it might be caused by another medical condition other than hepatitis B. Good luck.

  66. Hi, I got infected as an adult. No special pain other than been seldom tired ad having mild headache In fact, I have mild headache for most part of the day (22 hours approx.). Doctors says hepatitis does not cause headache. Is it still possible my immune naturally clears this? It is 4 years now

    1. Hello: Your doctor is correct, hepatitis B does not cause headaches. While there is no cure for hepatitis B, a small percentage of people are able to clear the hepatitis B surface antigen (HBsAg) over time. You should focus on eating healthy foods, getting exercise, and avoiding alcohol and cigarettes to stay as healthy as possible. Also, as your doctor probably recommends, be sure to get monitored regularly, including getting your liver enzymes (ALT or SGPT) tested to make sure the infection is not causing any liver damage. Good luck.

  67. Hi, I was HBsAg positive for 9 years, then this past August, I was HBsAg negative and HBsAb positive! Does this mean I am cured? Can the HBsAg become positive again? If so, what are the chances, and under what conditions?

    1. Hello: Congratulations! It is rare, but a small percentage of people with chronic hepatitis B do manage to clear the hepatitis B surface antigen (HBsAg) and develop surface antibodies. This can happen in people over time, whose hepatitis B has been inactive and have declining HBsAg levels. Yes, you are “cured,” but with some conditions. You still need to be monitored over time. Like the chicken pox virus (varicella), the hepatitis B virus unfortunately never entirely goes away. A small amount of virus always remains in your liver. If your immune system weakens because of age or another medical condition, hepatitis B can reactivate in the same way that older people develop shingles (a return of chicken pox) as their immune systems weaken and are no longer able to suppress the virus.
      So, keep getting monitored, and if later in life you ever require any immune-suppressing drugs for cancer (chemotherapy) or arthritis, be sure to tell your doctor about your hepatitis B. You may need to be carefully monitored and may even need antivirals to prevent your hepatitis B from reactivating. Good luck, you are very luck.

    2. please how did you manage it till it goes. tell us so we can also do the same. second,what drug were u taking to suppress it.

      1. The best thing to do is to get monitored regularly, avoid alcohol and cigarettes, and eat healthy foods. If you develop liver damage and require treatment, the two recommended antivirals are either tenofovir (Viread) or entecavir. Good luck.

  68. Hello i notice my Hepatitis B on june when i went for medical check up and i have done severial text and my Dr said i dont need any medication and this is my result below can you help me interprete it because i am not happy about this sickness and i need to marry and have a baby.
    ANTI-HCV RESULT 0.05 NON – REACTIVE
    HBV-DNA QUANTIFICATION 830 IU/ML NOT APPLICABLE

    MY HEPATITIST B PROFILE RESULT BELOW…
    HBsAg (Hep B Surface Antigen 250.0 Reactive
    Anti-HBsAg (Antibodies to Hep B surface Anti Reactive
    Anti-HbCAg- Total(Total antibodies to Hepatist 41.53 Reactive Index
    Anti -HBcAg-IgM (IgM antibodies to Hepatitis B co 0.12 Non-Reactive s/co
    HBeAg (Hepatitis B envelope antigen) 0.411 Non-Reactive Index
    Anti-HBeAg(Antibodies to Hepatitis B envelope Ant Reactive Index

    1. Hello: Your tests show you are infected with hepatitis B. In order to determine if you were recently infected and have an acute or short-term infection, you need to return to your doctor in six months and get tested again. If you are still infected and test positive for the hepatitis B surface antigen (HBsAg) at that time, it means you have a chronic infection and were probably infected at birth or during early childhood. In the meantime, it is important to avoid alcohol and cigarettes, eat healthy food and practice safe sex.
      Yes you can marry even if you have chronic hepatitis B. But before you marry or have sexual relations, you must make sure your partner is vaccinated against hepatitis B and has enough hepatitis B antibodies to protect them.
      Have them go to a doctor and get screened for hepatitis B. If they are not infected and haven’t been vaccinated in the past, they should get the three shots of the vaccine. (They may have been immunized during childhood.) The second shot is given 30 days after the first, and the third shot is given six months after the first shot.
      About one or two months after the third vaccine shot, have your partner screened for hepatitis B antibodies. Or, if they were immunized in the past, have them tested now to make sure they have enough antibodies to protect them. The number of antibodies should be more than 10 mIU/mL. That means they have enough antibodies to fight off infection.
      If they were immunized long ago, their titer levels may be under 10, if that is the case talk to your doctor and get one more hepatitis B vaccine shot (called a booster), and then test again to see if the antibodies have increased.
      Until you are certain that your partner has enough titers to fully protect them from hepatitis B, you must practice safe sex and use a condom. Good luck.

      1. Thanks so much for your help and right now it means they dont know if my hepatitis is acute or chronicle one until i go back to the dr after six months…also is it advisable to used drugs that will boost my immune system to fight for it.And since i notice my hepatitis my partner has went for her own text and she is negative and she did not know that i have it because i cant tell her now and i have been using condom for her and she dont like it…. Please how soon the drugs that will cure the hepatitis be out so that i can cure it fast and i have spend much money on test now and i am not happy. Also if my wife is vaccinated and she is pregnant hope our baby is safe and also hope i can play with the baby and kiss the baby as father.

        1. Hello: It is important that your partner is vaccinated against hepatitis B. Even if you are having safe sex, there is always a risk of spreading hepatitis B sexually. Just because she tests negative now does not mean she will be protected in the future. Once she has received all three shots, you can have unsafe sex and conceive a child without worrying that you will infect her or your child. Also, you should tell her about your infection, as trust is very important in a relationship.
          Hepatitis B is not spread casually, kissing, hugging and sharing food does not spread the infection. And, if your future children are immunized at birth, you never have to worry about infecting them. Also, in the meantime avoid alcohol and cigarettes, and continue to practice safe sex. Good luck.

          1. Thanks so much for your help and how soon the drugs that will cure the infection will be out and is it advisable to used drugs that will boost immune system.

  69. May God protect your life & increase your effort more 4 dis better innovation that wl soon give us hope. Iam 33, got tested 4 hepatitis b & since then i hv bn worried. Im a graduate bt unemployed . No money to take care of myself. May God help u.

    1. Hello: Please have faith. Most people with hepatitis B live long and healthy lives, especially if you eat healthy foods and avoid alcohol and cigarettes. There are effective medications if you need them, and experts predict a cure will be developed in the next few years. Good luck.

    1. Hello: Yes you are cured, as long as you have tested positive for the hepatitis B surface antibody (Anti HBs), which you have. Congratulations. No, you cannot infect others as you are no longer infected. Good luck.

  70. I am 55 years old about 12 years ago my skin would get itchy and hives from scratching ,i went to a dermatologist and i had no allergies but he found out i had hep b,i took Allegra for the itching for about 1 year since then i am not itchy anymore ,my husband got tested and he was fine ,even though we were sexually active i didn’t pass it on ,he got vaccinated ,i have regular blood test for my liver and everything seems to be okay.Is there a good chance i could have it for the rest of my life without any symptoms,since its been dormant all these years.

    1. Hello: Chronic hepatitis B can last for many years. However, it is excellent news that you have no liver damage and that you have a good doctor who monitors you regularly. As you age, it’s important to continue to get checked every six to 12 months (whatever your doctor recommends.) Also, be careful about any immune-suppressing drugs (such as for eczema or some other medical condition) as it can cause a reactivation of your hepatitis B. Good luck.

  71. Hello sir
    Last month I got to know that I am hbsag positive. Then I went for medical check and below is my result
    Hbsag :positive
    Hbeag : -ve
    Ultrasound shows fatty liver
    Lipid profile:
    Cholesterol (Total), serum by Enzymatic method227NCEP GuidelinesTriglycerides, serum by Enzymatic method222NCEP GuidelinesHDL Cholesterol, serum by Enzymatic method34NCEP GuidelinesVLDL Cholestrol, serum by calculation445 to 51 mg/dLLDL Cholesterol, serum by calculation149NCEP GuidelinesCholesterol(Total)/HDL Cholesterol Ratio6.68Males : Acceptable ratio </= 5.00Females : Acceptable ratio </= 4.50LDL Cholesterol/HDL Cholesterol Ratio4.37Males : Acceptable ratio </= 3.60F

    Sgpt :61
    Hbv dna: 35000ul/ml

    I feel no symptoms of hepatitis.
    I visited doc and he said it is not that high. So he didn't prescribed me any medicine and told me to test again for hbv dna after two months.

    I want to know am I chronic or actute hepatitis nd how long i will live.
    Thanks

    1. Hello: When you test positive for the hepatitis B surface antigen (HBsAG), it means you are currently infected with hepatitis B. When a healthy adult is infected with hepatitis B, most are able to get rid of the virus on their own within six months, so you need to be tested again in six months to find out if it’s chronic or acute. When newborns or children are infected, their immature immune systems don’t recognize or fight the infection, and it becomes long-term or chronic.
      Your tests currently show you have fatty liver and hepatitis B, when you have both of these conditions, they can accelerate or increase your risk of liver damage. Your SGPT of 61 is slightly above normal. Our liver cells release SGPT into the blood when they are damaged. Also your viral load is quite high.
      Please continue to get monitored as your doctor recommends, avoid alcohol and cigarettes, and try to eat healthy food and lose weight, which will help you live a long and healthy life. Good luck.
      Good luck.
      The only way to find out if

      1. Hi..
        Thank you for reply.
        I had jaundice 6 yrs back and recovered that time. Is it possible that it was not recovered completely that time?

  72. I have a chronic hepatitis b. What would be the best way to stay my body healthy? Is there any possibilities that someday I’ll be free from this kind of disease?

    1. Hello: While there is no cure, as long as you lead a healthy lifestyle and avoid alcohol and cigarettes, you are doing the best you can to stay healthy. Many people living with hepatitis B live long and healthy lives. Most never need treatment unless if virus is damaging their liver. Experts predict a cure will be developed in several years, we remain very optimistic. Good luck.

    1. Hello: The stomach/indigestion problem you describe is not a common symptom of hepatitis B. Please contact your doctor to see if another medical issue is causing you this discomfort. Good luck.

  73. I went for hepatitis b test this month and I was tested positive. My result was hbsAg positive. Pls what does that mean?

    1. Hello: When we are infected with the hepatitis B virus, we test positive for the hepatitis B surface antigen (HBsAg). Is this the first time you have been tested for hepatitis B? To know if you were recently infected and have a short-term “acute” infection or a long-term chronic infection, you need to be tested again in six months.
      When healthy adults are infected, it takes about six months for their immune systems to get rid of the infection. The last hepatitis B “antigen” to disappear is the surface antigen (HBsAg). When newborns or children are infected, their immature immune systems don’t recognize and fight the infection and it can become chronic and last for many years.
      If this was the first time you were tested, please get tested again in six months to see if it’s chronic or acute. Also, please avoid alcohol and cigarettes, and eat healthy foods. Good luck.

    2. Hello: When we are infected with the hepatitis B virus, we test positive or reactive for the hepatitis B surface antigen (HBsAg). As our immune systems start to fight the infection, they produce antibodies to eradicate or get rid of the hepatitis B antigens.
      Is this the first time you have been tested for hepatitis B? To know if you were recently infected and have a short-term “acute” infection, you need to be tested again in six months.
      When healthy adults are infected, it takes about six months for their immune systems to get rid of the infection. The last hepatitis B “antigen” to disappear is the surface antigen (HBsAg). When newborns or children are infected, their immature immune systems don’t recognize and fight the infection and it can become chronic and last for many years.
      Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B especially if they don’t drink or smoke. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment.

  74. Hello i have hep B and my girl friend is vacinated with the vasine is it safe for us to have sex without condom. Also if we want to have a baby hope our baby will not be infected and what can we do to protect the baby.

    1. Hello: Before you have unprotected sex, she should get tested to make sure she responded to the vaccine and has enough hepatitis B surface antibodies to protect her from infection. Medical guidelines recommend that we should have at least 10 mIU/mL of surface antibodies to be fully protected. It is natural for surface antibodies to decline over years, however our immune system retains an “immune memory” and is usually ready to protect us. However, if her antibody levels are low, her doctor may recommend a booster shot.
      Once you know she is protected, you can have unprotected sex. Make sure your baby is vaccinated at birth so you do not have to worry about spreading the infection. Good luck.

    2. Hello my girlfriend went to check her ANTI HBS- HEPATITIS B SURFACE ANTI BODY and the result is 28.05(Reactive)hope she is safe to have unprotected sex with me and i will go for another text this month because is 6 months for my check up now.pls advice.

      1. Hello:
        As long as someone has at least 10 mIU/mL of hepatitis B surface antibodies, they have immunity against hepatitis B. With your girlfriend’s level of 28 mIU/mL, she is protected. Good luck.

    1. Hello: Jaundice — the yellowing of your skin or eyes — is an indication of liver damage. Hepatitis B can cause jaundice when someone is newly infected with hepatitis B. Please go and get tested for the hepatitis B surface antigen and antibody to find out. Good luck.

  75. I really hope to get answer for this. My boyfriend has chronic hep B, while I had vaccine years ago and my blood test shows my antigen and antibody is perfect and no need vaccine. My doctor said I will not get infected by my boyfriend hep B virus forever. Is it true, I love my boyfriend but I love myself too that I do not want to get hep B. Please advise, thank you so very much!!!

    1. I saw the your comment above for other friend that answered my question. But how if we get married and have sex regularly, how do I know if my surface antibody is getting low? how often do I have to have blood test? usually I have annual blood test. Thank you so much.

      1. Hello: Once you have at least 10 mIU/mL of hepatitis B surface antibodies, you are forever protected against hepatitis B, even if your surface antibodies fluctuate or even fall below the 10 mIU/mL level. Basically, your immune system is now on notice to quickly generate antibodies and fight the infection if you are ever exposed to the virus. Good luck.

    2. Hello: Your doctor is correct, you are permanently protected against hepatitis B once you have generated at least 10 mIU/mL of hepatitis B surface antibodies. This vaccine is different than the annual flu vaccine that we need every year. We need a new flu vaccine every year because the flu virus mutates and changes. The hepatitis B virus doesn’t change, the vaccine is effective against it indefinitely. Good luck, you will not get hepatitis B if you are immunized and have achieved at least 10 mIU/mL of surface antibodies. Good luck, thanks for your good question.

      1. Thank you so very much for your advice. I really really appreciate your help!!!!!
        God bless your kind heart and help!!!!
        I feel great now, thanks!!!!

  76. Hi I have chronic HBV and my HBsAg is reactive and HBeAG is non reactive and viral load is 3358 copies/ML and ALT also normal. Doctors advised no need to take treatment. Now i am going to marry. Kindly give me an advise of doses.

    1. Hello: You are lucky in that your hepatitis B is “inactive,” which means your immune system is controlling the infection so it is not replicating and producing lots of virus, nor is it causing any damage to your liver. It is important to get monitored regularly, eat healthy foods, and of course avoid alcohol and cigarettes.
      Now to your marriage: There are some important steps to take to make sure your partner and your future children do not become infected. Before you marry or have sexual relations, you must make sure your partner is vaccinated against hepatitis B and has enough hepatitis B antibodies (HBsAb) to protect them. Have them go to a doctor and get screened for hepatitis B. If they are not infected and haven’t been vaccinated in the past, they should get the three shots of the vaccine. (They may have been immunized during childhood.) The second shot is given 30 days after the first, and the third shot is given six months after the first shot.
      About one or two months after the third vaccine shot, have your partner screened for hepatitis B antibodies. Or, if they were immunized in the past, have them tested now to make sure they have enough antibodies to protect them. The number of antibodies should be more than 10 mIU/mL. That means they have enough antibodies to fight off infection.
      If they were immunized long ago, their antibody levels may be under 10, if that is the case have her get one more hepatitis B vaccine shot (called a booster), and then test again to see if the antibodies have increased.
      Until you are certain that your partner has enough titers to fully protect them from hepatitis B, you must practice safe sex and use a condom.
      Congratulations, and good luck.

  77. Hi thank you very much for giving much clarification on my query. I hope that once the solution found I will be recover as well as many people from the virus.

    1. Hello: I wish I knew. Researchers are making great progress, but experts predict a cure should be developed in the next few years. We are optimistic. Good luck.

  78. Hi i av been diagnosed with hpb chronic and am really confused i feel my life have come to an end. Please help me before i do something to myself

    1. Hello: Please, your life has not come to an end. The majority of people with hepatitis B have long and healthy lives. Do not let your hepatitis B infection define you.
      As one of the leaders of the patient email support group has written, “You CAN Date. You CAN marry. You CAN have sex. You CAN have a normal life.
      “It’s not health, income, or outside circumstances that hold us back. It’s our perspective. There are many people who succeed in this world in the presence of severe obstacles. They succeed because they don’t let it limit them. And they don’t feel sorry for themselves – they use what they do have to their advantage.”
      Hepatitis B is not a punishment or a disability. It can be an opportunity to discover how to love and accept yourself. And to learn what really matters in relationships and life.
      Feel free to join the hepatitis B information and support email community at: http://hblist.net/
      Good luck.

    1. Hello: To date, there is no herbal remedy that has been scientifically shown to cure hepatitis B or reduce liver damage. Investigations are underway, but so far none have been found to be effective in objective clinical trials.
      Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver. Good luck.

  79. please my total protein is 7.4(range:4.1-8.0) g/DL
    albumin 4.2 (3.5-5.3)
    globulins 3.2 (2.2-5.5) g/DL
    Total bilirubin 12.68
    Direct bilirubin 4.68
    indirect bilurubin 7.95
    AST 26.3 (0.0-35.0) U/L
    ALT 24.2 (0.0-45.0) U/L
    GGT 7.9 (0.0-49.0) U/L
    ALP 72.9 (42-406) U/L

    please interpret for me.

    1. Hello: I can only address your ALT level. ALT (also called SGPT) is an enzyme that liver cells release into the bloodstream when they are injured by hepatitis B, fatty liver or toxins. Healthy or average ALT/SGPT levels for women are up to 19 and for men they range up to 30 (or in your lab’s case 45). Your ALT of 24 is in the healthy range, which indicates your hepatitis B is not currently harming the liver. Your doctor takes ALT, viral load (HBV DNA), age, gender and overall health into consideration when deciding if you need treatment or how often to monitor you. Good luck.

    1. Hello: Livolyn is an herbal supplement that has not been clinically proven to improve liver health or cure hepatitis B. Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver, including avoiding alcohol and cigarettes. Good luck.

  80. Hi Recently my wife got first series vaccination (Shanvac B). She has to get 2nd shot after one month. Now i have a query regarding vaccination. Shall we need to use same brand vaccination for 2nd and 3rd shot or can use another brand also. I appreciate your help.

    1. Hello: She does not need the same brand for all three vaccine shots. As long as it is a hepatitis B vaccine, it will do the job! Congratulations on making sure your wife is protected. Good luck.

  81. Hi, I have been tested hepb positive for seven years now. And the last time i ALT test it was ok. I haven’t taken any antiviral drug. But am worried daily of what is going to become of me. Please advice me

    1. Hello: Medical guidelines DO NOT recommend treatment unless you are experiencing liver damage, which would be indicated by a high ALT level. As long as you are getting monitored regularly, you do not have to worry about treatment as long as you have no signs of liver damage. You may also want to get a liver ultrasound at some point for another analysis of your liver health. Keep eating healthy foods and avoid alcohol and cigarettes. Good luck.

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