Drug Watch
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Compounds in Development for Chronic Hepatitis B
Updated June 17, 2025
FAMILY/DRUG NAME |
MECHANISM |
COMPANY |
WEBSITE |
|
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| Interferons: Mimic infection-fighting immune substances naturally produced in the body | |||||||||
| Intron A (Interferon alfa 2b) | Immunomodulator | Merck, USA | merck.com | Approved 1991 | |||||
|
Pegasys (Peginterferon alfa 2a) |
Immunomodulator |
Approved 2005 |
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| Nucleos(t)ide Analogues: Interfere with viral DNA polymerase used for HBV replication | |||||||||
|
Epivir (Lamivudine) *Generics available |
Inhibits viral DNA polymerase | GlaxoSmithKline (GSK) | gsk.com | Approved 1998 | |||||
| Hepsera (Adefovir dipivoxil) *Generics available | Inhibits viral DNA polymerase | Gilead Sciences, USA | gilead.com | Approved 2002 | |||||
|
Baraclude (Entecavir) *Generics available |
Inhibits viral DNA polymerase | Bristol-Myers Squibb, USA | bms.com | Approved 2005 | |||||
| Tyzeka (Telbivudine) *Generics available | Inhibits viral DNA polymerase | Novartis, USA | novartis.com | Approved 2006 | |||||
| Viread (Tenofovir) *Generics available | Inhibits viral DNA polymerase | Gilead Sciences | gilead.com | Approved 2008 | |||||
| Vemlidy (TAF or tenofovir alafenamide) | Prodrug of Tenofovir | Gilead Sciences | gilead.com | Approved 2016 | |||||
|
Levovir (Cledvudine) |
Inhibits viral DNA polymerase | Bukwang, S. Korea | bukwang.co.kr | Approved 2006 in S. Korea | |||||
|
Direct Acting Antivirals: Targets the virus and interferes in the HBV replication process |
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Silencing RNA’s (siRNAs): Interferes and destroys viral RNA |
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|
Imdurisan (AB-729) |
RNAi gene silencer |
Phase II | |||||||
|
BW-20507 |
RNAi gene silencer |
Phase II |
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|
DAP/TOM or daplusiran-tomligisiran (GSK7608) in combination with Bepirovirsen |
RNAi gene silencer |
Phase II |
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|
GSK 5637608 (JNJ-3989) |
RNAi gene silencer |
gsk.com | Phase II | ||||||
|
HT-101 |
RNAi gene silencer |
www.hepathera.com/eng | Phase I (outside USA) | ||||||
|
Entry Inhibitors: Interferes with HBV getting into liver cells |
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|
Bulevirtide (Hepcludex) |
Entry inhibitor |
Phase III |
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|
Hepalatide (with PEG-IFN) |
Entry inhibitor |
Phase II | |||||||
|
Capsid or Core Inhibitors: Interferes with the viral DNA protein shield |
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|
ZM-H1505R |
Capsid inhibitor |
Phase II |
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EDP-514 |
Capsid inhibitor |
Phase I |
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|
ALG-000184 |
Capsid inhibitor |
Phase I | |||||||
|
ABI-4334 |
Capsid inhibitor |
Phase I | |||||||
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HBsAg Inhibitors: Interferes with production of HBV surface antigen (sAg) |
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|
REP 2139 |
sAg inhibitor |
Phase II |
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Antisense Molecules: Binds to the viral mRNA to prevent it from turning into viral protein |
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|
Bepirovirsen |
HBV Antisense |
Phase III |
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|
AHB-137 |
HBV Antisense |
Phase II, PR China |
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Gene Editing: Intended to destroy or repress HBV DNA |
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| PBGENE-HBV | ARCUS platform | precisionbiosciences.com | Phase I | ||||||
|
EBT107 |
CRISPR/Cas 9 |
excisionbio.com | Preclinical | ||||||
|
TUNE-401 |
TEMPO platform | Tune Therapeutics, USA | tunetx.com | Preclinical | |||||
|
CRMA-1001 |
Chroma Platform | Chroma Medicine, USA | chromamedicine.com | Preclinical | |||||
|
Immunologicals: Targets the human immune system to attack the HBV virus |
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Therapeutic Vaccine Technology used to stimulate the immune system as a treatment |
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|
VBI-2601 (BRII-179) |
Therapeutic vaccine |
VBI Vaccines with |
Phase II | ||||||
|
VVX001 |
Therapeutic vaccine |
Phase II |
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VTP-300 |
Therapeutic vaccine |
Phase II |
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CVI-HBV-002 |
Therapeutic vaccine |
Phase II |
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|
HB-400 (GS2829/GS6779) |
Therapeutic vaccine |
hookipapharma.com; gilead.com | Phase I | ||||||
|
ISA104 |
Therapeutic vaccine |
isa-pharma.com | Phase I | ||||||
|
VRON-0200 |
Therapeutic vaccine |
viriontx.com | Phase I | ||||||
| CLB-3000 |
Therapeutic vaccine |
Clear B Therapeutics, USA | clearbtherapeutics.com | Phase I | |||||
| TherVacB | Therapeutic vaccine | TherVacB, Germany | thervacb.eu | Phase I | |||||
| GS-2829 | Therapeutic vaccine | Gilead Sciences, USA | gilead.com | Phase I | |||||
| GS-6779 | Therapeutic vaccine | Gilead Sciences, USA | gilead.com | Phase I | |||||
| AVX70371 | Therapeutic vaccine | AstriVax, Belgium | astrivax.com | Phase I | |||||
| CARG-201 | Therapeutic vaccine | CaroGen, USA | carogencorp.com | Preclinical | |||||
|
AHB-201 |
Therapeutic vaccine |
Preclinical |
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|
AHB-837 |
Therapeutic vaccine |
Preclinical |
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|
Compounds that activate the innate immune system |
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|
Selgantolimod (GS9688) |
TLR-8 agonist |
Phase II |
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|
CB06 |
TLR-8 agonist |
core-biopharma.com | Phase I | ||||||
|
GSK 5251738 |
TLR-8 agonist |
gilead.com | Phase I | ||||||
|
Cavrotolomid |
TLR9-agonist | bluejaytx.com | Phase I | ||||||
|
Monoclonal Antibodies: Neutralize or bind the HBV proteins to reduce infection |
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| Burfiralimab (IgG4) | Monoclonal antibody | ImmuneMed, South Korea | immunemed.co.kr/eng | Phase II | |||||
|
BJT-778 |
Monoclonal antibody | Blue Jay Therapeutics, USA | bluejaytx.com | Phase I | |||||
|
GIGA-2339 |
Polyclonal antibody | GigaGen, USA | gigagen.com | Preclinical | |||||
|
HT-102 |
Monoclonal antibody | Hepa Thera, PR China | www.hepathera.com/eng | Preclinical | |||||
|
Checkpoint Inhibitors: Stimulate exhausted T-cell recognition of HBV-Infected cells |
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ASC22 |
PDL1 inhibitor | Ascletis Pharma, PR China | ascletis.com | Phase II | |||||
|
AB-101 |
PDL1 inhibitor | Arbutus, USA | arbutusbio.com | Phase I | |||||
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Other Immunologicals |
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IMC-1109V |
T-cell Receptor | Immunocore, UK and USA | immunocore.com | Phase I | |||||
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Additional HBV Drugs Under Investigation |
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GSK 4388067A |
Targeted immunotherapy | GSK, USA | gsk.com | Phase II | |||||
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APG-1387 |
Apoptosis inducer | Ascentage, PR China | ascentagepharma.com | Phase II | |||||
|
Elebsiran (VIR-2218), Tobevibart (VIR-3434) + PEG-IFN-a |
RNAi gene silencer and Monoclonal antibody | Vir Biotech, USA | vir.bio | Phase II - on hold for a partner | |||||
|
GSK 3965193 |
PAPD5/PAPD7 inhibitor |
GSK, USA | gsk.com | Phase I/II | |||||
|
DF-006 |
Small molecule | Drug Farm with Amoytop, PR China | drug-farm.com | Phase I | |||||
|
AB359 |
CD8 IL-2 immunotherapy | Asher Biotherapeutics, USA | Preclinical | ||||||
|
BJT-628 |
Small molecule | Blue Jay Therapeutics, USA | bluejaytx.com | Preclinical | |||||
|
Hepatitis Delta Virus (HDV)- A virus that co-infects people already infected with HBV |
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Hepcludex (Bulevirtide formerly Myrcludex B) |
Entry inhibitor |
Phase III USA, EU approved 2023 |
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Elebsiran (VIR-2218) and Tobevibart (VIR-3434) |
RNAi gene silencer + Monoclonal antibody | vir.bios | Phase III | ||||||
|
REP 2139 |
HBsAg inhibitor |
Phase II |
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BJT-778 |
Monoclonal antibody |
Phase II | |||||||
|
ABI-6250 |
Entry inhibitor |
assemblybio.com | Preclinical | ||||||
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