Drug Watch
Compounds in Development for Chronic Hepatitis B
Updated February 11, 2020
FAMILY/DRUG NAME |
MECHANISM |
COMPANY |
WEBSITE |
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Interferons: Mimic infection-fighting immune substances naturally produced in the body. |
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Intron A (Interferon alfa-2b) |
Immunomodulator |
Merck, USA |
Approved 1991 |
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Pegasys (Peginterferon alfa-2a) |
Immunomodulator |
Genentech, USA |
Approved 2005 |
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Epivir (Lamivudine) |
Inhibits viral DNA polymerase |
GlaxoSmithKline (GSK) |
Approved 1998 |
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Hepsera (Adefovir dipivoxil) |
Inhibits viral DNA polymerase |
Gilead Sciences, USA |
Approved 2002 |
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Baraclude (Entecavir) |
Inhibits viral DNA polymerase |
Bristol-Myers Squibb, USA |
Approved 2005 |
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Tyzeka (Telbivudine) |
Inhibits viral DNA polymerase |
Novartis, USA |
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Viread (Tenofovir) |
Inhibits viral DNA polymerase |
Gilead Sciences |
Approved 2008 |
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Vemlidy (TAF or tenofovir alafenamide) |
Prodrug of tenofovir |
Gilead Sciences |
Approved 2016 |
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Levovir (Clevudine) |
Inhibits viral DNA polymerase |
Bukwang, S. Korea |
Approved 2006 in S. Korea |
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Besivo (formerly ANA 380/LB80380) |
Inhibits viral DNA polymerase |
Ildong Pharma, S. Korea |
Approved 2017 in S. Korea |
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Zadaxin |
Immunomodulator |
SciClone, USA |
Approved outside USA |
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DIRECT ACTING ANTIVIRALS: Targets the virus and interferes in the HBV replication process |
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Silencing RNA’s (siRNAs): Interferes and destroys viral RNA |
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VIR-2218 |
RNAi gene silencer |
Alnylam and Vir Biotech, USA |
Phase II |
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RG6346 (DCR HBVS) |
RNAi gene silencer |
Roche, Switzerland |
Phase I/II |
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ARO-HBV |
RNAi gene silencer |
Arrowhead Pharma with Janssen, USA |
Phase I/II | |
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AB-729 |
RNAi gene silencer |
Arbutus Biopharma, USA |
Phase I | |
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BB-103 |
RNAi gene silencer |
Benitec, Australia |
Preclinical |
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Lunar-HBV |
RNAi gene silencer |
Arcturus with Janssen, USA |
Preclinical |
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Entry Inhibitors: Interferes with HBV getting into liver cells |
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Bulevirtide (Myrcludex B) |
Entry inhibitor |
Hepatera, Russia with MYR GmbH, Germany |
Phase IIb |
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Capsid Inhibitors: Interferes with the viral DNA protein shield |
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Morphothiadin |
Capsid inhibitor |
HEC Pharma, |
Phase II |
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JNJ 56136379 |
Capsid inhibitor |
Janssen, Ireland |
Phase II |
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ABI-H0731 |
Capsid inhibitor |
Assembly Biosciences, USA |
Phase II |
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ABI-H2158 |
Capsid inhibitor |
Assembly Biosciences, USA |
Phase I | |
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RG7907 |
Capsid inhibitor |
Roche, Switzerland |
Phase I | |
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QL-007 |
Capsid inhibitor |
Qilu, PR China |
Phase I | |
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EDP-514 |
Capsid inhibitor |
Enanta Pharma, USA |
Phase I | |
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GLP-26 |
Capsid inhibitor |
Emory University, USA |
Preclinical | |
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ABI-H3733 |
Capsid inhibitor |
Assembly Biosciences, USA |
Preclinical | |
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CB-HBV-001 |
Capsid inhibitor |
ZhiMeng Biopharma, PR China |
Preclinical | |
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ALG-000184 |
Capsid inhibitor |
Aligos Therapeutics, USA |
Preclinical | |
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HBsAg Inhibitors: Interferes with production of HBV surface antigen (sAg) |
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REP 2139 |
sAg inhibitor |
Replicor, Canada |
Phase II |
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REP 2165 |
sAg inhibitor |
Replicor, Canada |
Phase II |
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ALG-10133 |
STOPs (s-Antigen transport inhibiting oligonucleotide polymers) |
Aligos Therapeutics, USA |
Preclinical | |
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Antisense Molecules: Binds to the viral mRNA to prevent it from turning into viral protein |
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GSK 3228836 (IONIS-HBVRx) |
Prevent viral protein production |
Ionis with GSK, USA |
Phase II |
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ALG-ASO |
Prevent viral protein production |
Aligos Therapeutics, USA |
Preclinical | |
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INDIRECT ACTING ANTIVIRALS: Targets the human immune system to attack the HBV virus |
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Therapeutic Vaccines: Vaccine technology used to stimulate the immune system as a treatment |
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AIC 649 |
Therapeutic vaccine |
AiCuris, Germany |
Phase I |
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INO-1800 |
Therapeutic vaccine |
Inovio, USA |
Phase I |
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HB-110 |
Therapeutic vaccine |
Ichor Medical Genexine, USA |
Phase I |
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TG1050 |
Therapeutic vaccine |
Transgene, France |
Phase I |
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HepTcell |
Therapeutic vaccine |
Altimmune, USA |
Phase I |
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JNJ 64300535 |
Therapeutic vaccine |
Janssen, Ireland |
Preclinical |
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HBV |
Therapeutic vaccine |
GeoVax, USA |
Preclinical |
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VBI-2601 |
Therapeutic vaccine |
VBI Vaccines, USA |
vbivaccines.com | Preclinical |
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Chimigen HBV |
Therapeutic vaccine |
Akshaya, Canada |
akshayabio.com | Preclinical |
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CARG-201 |
Therapeutic vaccine |
CaroGen, USA |
carogencorp.com | Preclinical |
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HBV |
Therapeutic vaccine |
HOOKIPA Pharma, Austria, with Gilead |
hookipapharma.com/ | Preclinical |
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TherVacB |
Therapeutic vaccine |
Helmholtz Zentrum Muenchen, Germany |
www.dzif.de/en/hepatitis | Preclinical |
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Innate Immune Defense Pathway: Compounds that activate the innate immune system |
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GS9688 |
TLR-8 agonist |
Gilead Sciences, USA |
Phase I |
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RG7854 |
TLR-7 agonist |
Roche, Switzerland |
Phase I | |
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Host Acting Pathway: Compounds that target cell functions needed by the hepatitis B virus |
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APG-1387 |
Apoptosis Inducer |
Ascentage Pharma, PR China |
Phase I |
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CRV 431 |
Ciclofillin inhibitor |
Hepion, USA (formerly ContraVir) |
Phase I |
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Gene Editing |
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EBT106 |
CRISPR/Cas 9 | Excision Bio, USA | www.excisionbio.com | Preclinical |
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HBV |
ARCUS platform | Precision Bio with Gilead, USA | precisionsciences.com | Preclinical |
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GC1102 |
monoclonal anti-HBsAg antibody | Green Cross, South Korea | www.globalgreencross.com | Phase II |
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EYP001 |
FXR agonist | Enyo Pharma, France | enyopharma.com | Phase I |
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RG6084 |
Host targeting antisense (LNA) | Roche, Switzerland | roche.com | Phase I |
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RG6217 |
Host targeting antisense (LNA) | Roche, Switzerland | roche.com | Phase I |
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ASC22 (KN035) |
PD-L1 | Ascletis Pharma, PR China | www.ascletis.com | Phase I |
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LTCR-H2-1 |
T Cell immunotherapy | Lion TCR, Singapore | www.liontcr.com | Preclinical |
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HBV |
MicroRNA | Regulus, USA | regulusrx.com | Preclinical |
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ENOB-HB-01 |
Nucleic Acid-directed HBV cell killing | Enochian BioSciences, USA | enochianbio.com | Preclinical |
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HEPATITIS DELTA VIRUS (HDV)- A virus that co-infects people already infected with HBV |
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Lambda (Pegylated Interferon) |
Immunomodulator |
Eiger Biopharma, USA |
Orphan drug |
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Bulevirtide (Myrcludex B) |
Entry inhibitor |
MYR-GmbH, Germany |
Phase III |
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Lonafarnib |
Prenylation inhibitor |
Eiger Biopharma, USA |
Orphan drug |
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REP 2139 |
HBsAg inhibitor |
Replicor, Canada |
Phase II |
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Ezetimibe |
NTCP inhibitor |
Ziauddin University Hospital, Pakistan |
Phase II |
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GI-18000 |
Immune Response Stimulator |
GlobeImmune |
Preclinical |
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