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Journal articles recommended by our Emerging Scholars Scientific and Medical Advisors

We are asking some emerging scholars in the field of hepatitis B basic and clinical research, on a monthly basis, to tell us what they are reading. Below are their responses.

The “Picks of the Month” are the papers most commonly recommended by the scholars. 

PICKS OF THE MONTH - July 2022

TRANSLATIONAL SCIENCE

Papatheodoridi M, Papachristou E, Moschidis Z, Hadziyannis E, Rigopoulou E, Zachou K, Villeret F, Magiorkinis G, Lyberopoulou A, Gatselis N, Vlachogiannakos I, Manolakopoulos S, Dalekos GN, Zoulim F, Paraskevis D, Papatheodoridis GV. Significance of serum HBV RNA in non-cirrhotic HBeAg-negative chronic hepatitis B patients who discontinue effective antiviral therapy. J Viral Hepat. 2022 Jul 5. doi:10.1111/jvh.13729. 
https://pubmed.ncbi.nlm.nih.gov/35789515/ 

Wu CR, Kim HJ, Sun CP, Chung CY, Lin YY, Tao MH, Kim JH, Chen DS, Chen PJ. Mapping the conformational epitope of a therapeutic monoclonal antibody against HBsAg by in vivo selection of HBV escape variants. Hepatology. 2022 Jul;76(1):207-219. doi: 10.1002/hep.32307. Epub 2022 Jan 16. 
https://pubmed.ncbi.nlm.nih.gov/34957587/

CLINICAL SCIENCE 

Kramvis A, Chang KM, Dandri M, Farci P, Glebe D, Hu J, Janssen HLA, Lau DTY, Penicaud C, Pollicino T, Testoni B, Van Bömmel F, Andrisani O, Beumont-Mauviel M, Block TM, Chan HLY, Cloherty GA, Delaney WE, Geretti AM, Gehring A, Jackson K, Lenz O, Maini MK, Miller V, Protzer U, Yang JC, Yuen MF, Zoulim F, Revill PA. A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook. Nat Rev Gastroenterol Hepatol. 2022 Jul 20:1–19. doi: 10.1038/s41575-022-00649-z. Epub ahead of print. 
https://pubmed.ncbi.nlm.nih.gov/35859026/

Huang DQ, Li X, Le MH, Le AK, Yeo YH, Trinh HN, Zhang J, Li J, Wong C, Wong C, Cheung RC, Yang HI, Nguyen MH. Natural History and Hepatocellular Carcinoma Risk in Untreated Chronic Hepatitis B Patients with Indeterminate Phase. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1803-1812.e5. doi: 10.1016/j.cgh.2021.01.019. Epub 2021 Jan 16.
https://pubmed.ncbi.nlm.nih.gov/33465482/

PUBLIC HEALTH 

Lee DH, Chung SW, Lee JH, Kim HY, Chung GE, Kim MS, Yang BR, Nam JY, Lee YB, Kim YJ, Yoon JH. Association of Chronic Hepatitis B Infection and Antiviral Treatment With the Development of the Extrahepatic Malignancies: A Nationwide Cohort Study. J Clin Oncol. 2022 May 13:JCO2101285. doi: 10.1200/JCO.21.01285. Epub ahead of print.

Hsieh YC, Pan MH, Jeng WJ, Hu HH, Liu J, Mizokami M, Chen CJ, Yang HI. Serum HBcrAg and hepatocellular carcinoma in a Taiwanese population seronegative for HBsAg and anti-HCV. Clin Gastroenterol Hepatol. 2022 Jul 15:S1542-3565(22)00658-9. doi: 10.1016/j.cgh.2022.06.018. Epub ahead of print. 
https://pubmed.ncbi.nlm.nih.gov/35850414/

BASIC SCIENCE

Hong X, Hu J. Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation. J Virol. 2022 Jul 18:e0071822. doi: 10.1128/jvi.00718-22. Epub ahead of print. 
https://pubmed.ncbi.nlm.nih.gov/35867543/

Chu JYK, Chuang YC, Tsai KN, Pantuso J, Ishida Y, Saito T, Ou JJ. Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.
https://pubmed.ncbi.nlm.nih.gov/35858426/


 

PICKS OF THE MONTH - June 2022

TRANSLATIONAL SCIENCE

Hoogeveen RC, Dijkstra S, Bartsch LM, Drescher H, Aneja J, Robidoux MP, Cheney JA, Timm J, Gehring A, Fonseca de Sousa PS, Ximenez L, Peliganga LB, Pitts A, Blackburn FE, Boonstra A, Kim AY, Lewis-Ximenez LL, Lauer GM. Hepatitis B virus-specific CD4 T-cell responses differentiate functional cure from chronic surface antigen+ infection. J Hepatol. 2022 Jun 15:S0168-8278(22)00366-X. 
https://pubmed.ncbi.nlm.nih.gov/35716846/ 

Biswas S, Rust LN, Wettengel JM, Yusova S, Fischer M, Carson JN, Johnson J, Wei L, Thode T, Kaadige MR, Sharma S, Agbaria M, Bimber BN, Tu T, Protzer U, Ploss A, Smedley JV, Golomb G, Sacha JB, Burwitz BJ. Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity. Nat Commun. 2022 May 30;13(1):2995. doi: 10.1038/s41467-022-30593-0. PMID: 35637225; PMCID: PMC9151762.  
https://pubmed.ncbi.nlm.nih.gov/35637225/

CLINICAL SCIENCE

Yuen MF, Heo J, Kumada H, Suzuki F, Suzuki Y, Xie Q, Jia J, Karino Y, Hou J, Chayama K, Imamura M, Lao-Tan JY, Lim SG, Tanaka Y, Xie W, Yoon JH, Duan Z, Kurosaki M, Park SJ, Labio ME, Kumar R, Kweon YO, Yim HJ, Tao Y, Cremer J, Elston R, Davies M, Baptiste-Brown S, Han K, Campbell FM, Paff M, Theodore D. Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy. J Hepatol. 2022 Jun 14:S0168-8278(22)00351-8. 
https://pubmed.ncbi.nlm.nih.gov/35714812/

Shimakawa, et al. Rapid point-of-care test for hepatitis B core-related antigen to diagnose high viral load in resource-limited settings. Clinical Gastroenterology and Hepatology. June 10, 2022 (article in press). https://doi.org/10.1016/j.cgh.2022.05.PII: S1542-3565(22)00554-7 Ref: YJCGH58503 
https://pubmed.ncbi.nlm.nih.gov/35697265/

PUBLIC HEALTH

GBD 2019 Hepatitis B Collaborators. Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol Hepatol. 2022 Jun 20:S2468-1253(22)00124-8. doi: 10.1016/S2468-1253(22)00124-8. Epub ahead of print. PMID: 35738290. 
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(22)00124-8/fulltext

Lampertico P, Roulot D, Wedemeyer H. BULEVIRTIDE WITH OR WITHOUT PEGIFNα FOR PATIENTS WITH COMPENSATED CHRONIC HEPATITIS DELTA: FROM CLINICAL TRIALS TO REAL LIFE STUDIES. J Hepatol. 2022 Jun 22:S0168-8278(22)00373-7. 
https://pubmed.ncbi.nlm.nih.gov/35752223/

BASIC SCIENCE

Zhao K, Guo F, Wang J, Zhong Y, Yi J, Teng Y, Xu Z, Zhao L, Li A, Wang Z, Chen X, Cheng X, Xia Y. Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells. Hepatology. 2022 Jun 19. doi: 10.1002/hep.32622. 
https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32622

Hong X, Kawasawa YI, Menne S, Hu J. Host cell-dependent late entry step as determinant of Hepatitis B virus infection. PLoS Pathog. 2022 Jun 17;18(6):e1010633. doi: 10.1371/journal.ppat.1010633. Online ahead of print. PMID: 35714170 
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010633


 

PICKS OF THE MONTH - May 2022

TRANSLATIONAL SCIENCE 

Gane E, Pastagia M, Schwertschlag U, De Creus A, Schwabe C, Vandenbossche J, Slaets L, Fevery B, Smyej I, Wu LS, Li R, Siddiqui S, Oey A, Musto C, Van Remoortere P. Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults. Antivir Ther. 2021 May;26(3-5):58-68. doi: 10.1177/13596535211056581. Epub 2021 Oct 27. PMID: 35485332. https://pubmed.ncbi.nlm.nih.gov/35485332/

Johnson Valiente A, Liem KS, Schwarz KB, Rosenthal P, Murray KF, Mogul D, Teckman J, Rodriguez-Baez N, Schwarzenberg SJ, Feld JJ, Wong DK, Lewis-Ximenez LL, Lauer G, Hansen BE, Ling SC, Janssen HLA, Gehring AJ. The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B. J Infect Dis. 2022 Feb 1;225(3):470-475. doi: 10.1093/infdis/jiab373. PMID: 34286845. https://pubmed.ncbi.nlm.nih.gov/34286845/

CLINICAL SCIENCE

Yuen MF, Wong DK, Schluep T, Lai CL, Ferrari C, Locarnini S, Lo RC, Gish RG, Hamilton J, Wooddell CI, Mak LY, Given BD. Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment. Gut. 2022 Apr;71(4):789-797. doi: 10.1136/gutjnl-2020-323445. Epub 2021 Mar 12. PMID: 33712437. https://pubmed.ncbi.nlm.nih.gov/33712437/

Jang H, Yoon JS, Park SY, Lee HA, Jang MJ, Kim SU, Sinn DH, Seo YS, Kim HY, Kim SE, Jun DW, Yoon EL, Sohn JH, Ahn SB, Shim JJ, Jeong SW, Cho YK, Kim HS, Nam JY, Lee YB, Kim YJ, Yoon JH, Zoulim F, Lampertico P, Dalekos GN, Idilman R, Sypsa V, Berg T, Buti M, Calleja JL, Goulis J, Manolakopoulos S, Janssen H, Papatheodoridis GV, Lee JH. Impact of HBeAg on Hepatocellular Carcinoma Risk During Oral Antiviral Treatment in Patients With Chronic Hepatitis B. Clin Gastroenterol Hepatol. 2022 Jun;20(6):1343-1353.e16. doi: 10.1016/j.cgh.2021.09.001. Epub 2021 Sep 6. PMID: 34500103. https://pubmed.ncbi.nlm.nih.gov/34500103/

Hall SAL, Burns GS, Anagnostou D, Vogrin S, Sundararajan V, Ratnam D, Levy MT, Lubel JS, Nicoll AJ, Strasser SI, Sievert W, Desmond PV, Ngu MC, Angus P, Sinclair M, Meredith C, Matthews G, Revill PA, Jackson K, Littlejohn M, Bowden DS, Locarnini SA, Visvanathan K, Thompson AJ. Stopping nucleot(s)ide analogues in non-cirrhotic HBeAg-negative chronic hepatitis B patients: HBsAg loss at 96 weeks is associated with low baseline HBsAg levels. Aliment Pharmacol Ther. 2022 May 6. doi: 10.1111/apt.16968. Epub ahead of print. PMID: 35521992. https://pubmed.ncbi.nlm.nih.gov/35521992/

PUBLIC HEALTH

Alberts CJ, Clifford GM, Georges D, Negro F, Lesi OA, Hutin YJ, de Martel C. Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels: a systematic review. Lancet Gastroenterol Hepatol. 2022 May 13:S2468-1253(22)00050-4. doi: 10.1016/S2468-1253(22)00050-4. Epub ahead of print. PMID: 35576953. https://www.thelancet.com/journals/langas/article/PIIS2468-1253(22)00050-4/fulltext

Wong GLH, Gane E, Lok ASF. How to achieve functional cure of HBV: Stopping NUCs, adding interferon or new drug development? J Hepatol. 2022 Jun;76(6):1249-1262. doi: 10.1016/j.jhep.2021.11.024. PMID: 35589248. https://pubmed.ncbi.nlm.nih.gov/35589248/

BASIC SCIENCE

Park JH, Iwamoto M, Yun JH, Uchikubo-Kamo T, Son D, Jin Z, Yoshida H, Ohki M, Ishimoto N, Mizutani K, Oshima M, Muramatsu M, Wakita T, Shirouzu M, Liu K, Uemura T, Nomura N, Iwata S, Watashi K, Tame JRH, Nishizawa T, Lee W, Park SY. Structural insights into the HBV receptor and bile acid transporter NTCP. Nature. 2022 May 17. doi: 10.1038/s41586-022-04857-0. Epub ahead of print. PMID: 35580630. https://pubmed.ncbi.nlm.nih.gov/35580630/

Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. Structure of bile acid transporter NTCP crucial for hepatitis B virus entry. Nature. 2022 May 17. doi: 10.1038/s41586-022-04845-4. Epub ahead of print. PMID: 35580629. https://pubmed.ncbi.nlm.nih.gov/35580629/


 

PICKS OF THE MONTH - April 2022

TRANSLATIONAL SCIENCE

Yu G, Chen R, Zheng S, Liu Y, Zou J, Gu Z, Jiang B, Gao Q, Dai L, Peng J, Wang J, Lu F. A standardized assay for the quantitative detection of serum HBV RNA in chronic hepatitis B patients. Emerg Microbes Infect. 2022 Dec;11(1):775-785. doi: 10.1080/22221751.2022.2045874. https://europepmc.org/article/PMC/PMC8920369

Wang Y, Mei Y, Ao Z, Chen Y, Jiang Y, Chen X, Qi R, Fu B, Tang J, Fang M, You M, Zhang T, Yuan Q, Luo W, Xia N. A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy. Antiviral Res. 2022 Mar;199:105265. doi: 10.1016/j.antiviral.2022.105265. Epub 2022 Feb 17. https://pubmed.ncbi.nlm.nih.gov/35183645/

CLINICAL SCIENCE

Sonneveld MJ, Park JY, Kaewdech A, Seto WK, Tanaka Y, Carey I, Papatheodoridi M, van Bömmel F, Berg T, Zoulim F, Ahn SH, Dalekos GN, Erler NS, Höner Zu Siederdissen C, Wedemeyer H, Cornberg M, Yuen MF, Agarwal K, Boonstra A, Buti M, Piratvisuth T, Papatheodoridis G, Maasoumy B; CREATE Study Group. Prediction of Sustained Response After Nucleo(s)tide Analogue Cessation Using HBsAg and HBcrAg Levels: A Multicenter Study (CREATE). Clin Gastroenterol Hepatol. 2022 Apr;20(4):e784-e793. doi: 10.1016/j.cgh.2020.12.005. Epub 2020 Dec 10. https://pubmed.ncbi.nlm.nih.gov/33309804/

Bruxvoort K, Slezak J, Qian L, Sy LS, Ackerson B, Reynolds K, Huang R, Solano Z, Towner W, Mercado C, Jacobsen SJ. Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction. JAMA. 2022 Apr 5;327(13):1260-1268. doi: 10.1001/jama.2022.2540. Erratum in: JAMA. 2022 Apr 26;327(16):1618. https://pubmed.ncbi.nlm.nih.gov/35333303/

PUBLIC HEALTH

Bruce MG, Bruden D, Hurlburt D, Morris J, Bressler S, Thompson G, Lecy D, Rudolph K, Bulkow L, Hennessy T, Simons BC, Weng MK, Nelson N, McMahon BJ. Protection and Antibody Levels 35 Years after Primary Series with Hepatitis B Vaccine and Response to a Booster Dose. Hepatology. 2022 Mar 23. doi: 10.1002/hep.32474. Epub ahead of print. https://pubmed.ncbi.nlm.nih.gov/35320592/

Veracruz N, Gish RG, Cheung R, Chitnis AS, Wong RJ. Global incidence and mortality of hepatitis B and hepatitis C acute infections, cirrhosis and hepatocellular carcinoma from 2010 to 2019. J Viral Hepat. 2022 May;29(5):352-365. doi: 10.1111/jvh.13663. Epub 2022 Mar 15. https://pubmed.ncbi.nlm.nih.gov/35274406/

BASIC SCIENCE

Dörnbrack K, Beck J, Nassal M. Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro. PLoS Pathog. 2022 Mar 8;18(3):e1010362. doi: 10.1371/journal.ppat.1010362. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010362

Montanari NR, Ramírez R, Aggarwal A, van Buuren N, Doukas M, Moon C, Turner S, Diehl L, Li L, Debes JD, Feierbach B, Boonstra A. Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection. J Hepatol. 2022 Feb 24:S0168-8278(22)00123-4. doi: 10.1016/j.jhep.2022.02.016. Epub ahead of print. https://www.journal-of-hepatology.eu/article/S0168-8278(22)00123-4/fulltext

van Buuren N, Ramirez R, Soulette C, Suri V, Han D, May L, Turner S, Parvangada PC, Martin R, Chan HLY, Marcellin P, Buti M, Bui N, Bhardwaj N, Gaggar A, Li L, Mo H, Feierbach B. Targeted long-read sequencing reveals clonally expanded HBV-associated chromosomal translocations in patients with chronic hepatitis B. JHEP Rep. 2022 Feb 12;4(4):100449. doi: 10.1016/j.jhepr.2022.100449. https://www.jhep-reports.eu/article/S2589-5559(22)00021-0/fulltext


 

PICKS OF THE MONTH - March 2022

Translational Science

tative detection of serum HBV RNA in chronic hepatitis B patients. Yu G, Chen R, Zheng S, Liu Y, Zou J, Gu Z, Jiang B, Gao Q, Dai L, Peng J, Wang J, Lu F. A standardized assay for the quanti Emerg Microbes Infect. 2022 Dec;11(1):775-785. doi: 10.1080/22221751.2022.2045874. PMID: 35220917; PMCID: PMC8920369. https://pubmed.ncbi.nlm.nih.gov/35220917/

Wang Y, Mei Y, Ao Z, Chen Y, Jiang Y, Chen X, Qi R, Fu B, Tang J, Fang M, You M, Zhang T, Yuan Q, Luo W, Xia N.A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy. Antiviral Res. 2022 Mar;199:105265. doi: 10.1016/j.antiviral.2022.105265. Epub 2022 Feb 17. PMID: 35183645. https://www.sciencedirect.com/science/article/pii/S016635422200033X

Clinical Science

Bruxvoort K, Slezak J, Qian L, Sy LS, Ackerson B, Reynolds K, Huang R, Solano Z, Towner W, Mercado C, Jacobsen SJ. Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction.  JAMA. 2022 Mar 25. doi: 10.1001/jama.2022.2540. Epub ahead of print. PMID: 35333303. https://jamanetwork.com/journals/jama/fullarticle/2790492

Sonneveld MJ, Park JY, Kaewdech A, Seto WK, Tanaka Y, Carey I, Papatheodoridi M, van Bömmel F, Berg T, Zoulim F, Ahn SH, Dalekos GN, Erler NS, Höner Zu Siederdissen C, Wedemeyer H, Cornberg M, Yuen MF, Agarwal K, Boonstra A, Buti M, Piratvisuth T, Papatheodoridis G, Maasoumy B; CREATE Study Group. Prediction of Sustained Response After Nucleo(s)tide Analogue Cessation Using HBsAg and HBcrAg Levels: A Multicenter Study (CREATE). Clin Gastroenterol Hepatol. 2022 Apr;20(4):e784-e793. doi: 10.1016/j.cgh.2020.12.005. Epub 2020 Dec 10.  PMID: 33309804 https://pubmed.ncbi.nlm.nih.gov/33309804/

Public Health

Bruce MG, Bruden D, Hurlburt D, Morris J, Bressler S, Thompson G, Lecy D, Rudolph K, Bulkow L, Hennessy T, Simons BC, Weng MK, Nelson N, McMahon BJ. Protection and Antibody Levels 35 Years after Primary Series with Hepatitis B Vaccine and Response to a Booster Dose. Hepatology. 2022 Mar 23. doi: 10.1002/hep.32474. Online ahead of print.  PMID: 35320592 https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32474

Veracruz N, Gish RG, Cheung R, Chitnis AS, Wong RJ. Global incidence and mortality of hepatitis B and hepatitis C acute infections, cirrhosis and hepatocellular carcinoma from 2010 to 2019. J Viral Hepat. 2022 Mar 11. doi: 10.1111/jvh.13663. Epub ahead of print. PMID: 35274406. https://onlinelibrary.wiley.com/doi/abs/10.1111/jvh.13663

Basic Science

Dörnbrack K, Beck J, Nassal M. Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro. PLoS Pathog. 2022 Mar 8;18(3):e1010362. doi:10.1371/journal.ppat.1010362. eCollection 2022 Mar. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010362

van Buuren N, Ramirez R, Soulette C, Suri V, Han D, May L, Turner S, Parvangada PC, Martin R, Chan HLY, Marcellin P, Buti M, Bui N, Bhardwaj N, Gaggar A, Li L, Mo H, Feierbach B. Targeted long-read sequencing reveals clonally expanded HBV-associated chromosomal translocations in patients with chronic hepatitis B. JHEP Rep. 2022 Feb 12;4(4):100449. doi: 10.1016/j.jhepr.2022.100449. PMID: 35295767; PMCID: PMC8918852. https://www.sciencedirect.com/science/article/pii/S2589555922000210

Montanari NR, Ramírez R, Aggarwal A, van Buuren N, Doukas M, Moon C, Turner S, Diehl L, Li L, Debes JD, Feierbach B, Boonstra A. Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection. J Hepatol. 2022 Feb 23:S0168-8278(22)00123-4. doi: 10.1016/j.jhep.2022.02.016. Epub ahead of print. PMID: 35218813. https://www.journal-of-hepatology.eu/article/S0168-8278(22)00123-4/fulltext


PICKS OF THE MONTH - February 2022

Translational Science

Wang Y, Mei Y, Ao Z, Chen Y, Jiang Y, Chen X, Qi R, Fu B, Tang J, Fang M, You M, Zhang T, Yuan Q, Luo W, Xia N. A broad-spectrum nanobody targeting the C-terminus of the hepatitis B surface antigen for chronic hepatitis B infection therapy. Antiviral Res. 2022 Feb 17:105265. https://www.sciencedirect.com/science/article/pii/S016635422200033X

Clinical Science

Sonneveld MJ, Chiu SM, Park JY, Brakenhoff SM, Kaewdech A, Seto WK, Tanaka Y, Carey I, Papatheodoridi M, van Bömmel F, Berg T, Zoulim F, Ahn SH, Dalekos GN, Erler NS, Höner Zu Siederdissen C, Wedemeyer H, Cornberg M, Yuen MF, Agarwal K, Boonstra A, Buti M, Piratvisuth T, Papatheodoridis G, Chen CH, Maasoumy B; CREATE study group. Probability of HBsAg loss after nucleo(s)tide analogue withdrawal depends on HBV genotype and viral antigen levels. Journal of Hepatology 2022 Jan 26:S0168-8278(22)00020-4. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35092743/

Terrault N, Wahed A, Feld J, Cooper S, Ghany M, Lisker-Melman M, Perrillo R, Sterling R, Khalili M, Chung R, Rosenthal P, Fontana R, Sarowar A, Lau D, Wang J, Lok A, Janssen H. Incidence and Prediction of HBsAg Seroconversion in a Prospective Multi-ethnic HBeAg-Negative Chronic Hepatitis B Cohort. Hepatology. 2022 March; 75(3) 709-723. https://pubmed.ncbi.nlm.nih.gov/34743343/ 

Public Health

Lai MW, Chang YL, Cheng PJ, Chueh HY, Chang SC, Yeh CT. Absence of chronicity in infants born to immunized mothers with occult HBV infection in Taiwan. Journal of Hepatology 2022 Feb 14:S0168-8278(22)00078-2. https://pubmed.ncbi.nlm.nih.gov/35176439/

Emeasoba EU, Omarufilo F, Bosah JN, Sigal SH. Breaking down barriers for hepatitis B screening in the Bronx West African community through education in collaboration with faith-based organizations: A cohort study. The Lancet Regional Health-Americas. 2022 March 1;7:100120. https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(21)00116-2/fulltext

Basic Science

Pal S, Dey D, Chakraborty BC, Nandi M, Khatun M, Banerjee S, Santra A, Ghosh R, Ahammed SM, Chowdhury A, Datta S. Diverse facets of MDSC in different phases of chronic HBV infection: impact on HBV specific T cell response and homing. Hepatology 2022 Jan 9. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35000202/

Kim GW, Moon JS, Siddiqui A. N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein. Proceedings of the National Academy of Sciences USA. 2022 Feb 15;119(7):e2120485119. https://pubmed.ncbi.nlm.nih.gov/35135882/


 

PICKS OF THE MONTH - January 2022

Translational Science

Hsu YC, Suri V, Nguyen MH, Huang YT, Chen CY, Chang IW, Tseng CH, Wu CY, Lin JT, Pan DZ, Gaggar A, Podlaha O.

Inhibition of Viral Replication Reduces Transcriptionally Active Distinct Hepatitis B Virus Integrations with Implications on Host Gene Dysregulation.

Gastroenterology 2022;S0016-5085(22)00006-3. doi:10.1053/j.gastro.2021.12.286.

https://www.sciencedirect.com/science/article/pii/S0016508522000063?via%3Dihub 

Alex S. Genshaft, Sonu Subudhi, Arlin Keo, Juan D. Sanchez Vasquez, Nádia Conceição-Neto, Deeqa Mahamed, Lauke L. Boeijen, Nadia Alatrakchi, Chris Oetheimer, Mike Vilme, Riley Drake, Ira Fleming, Nancy Tran, Constantine Tzouanas, Jasmin Joseph-Chazan, Martin Arreola Villanueva, Harmen J. G. van de Werken, Gertine W. van Oord, Zwier M.A. Groothuismink, Boris J. Beudeker, Zgjim Osmani, Shirin Nkongolo, Aman Mehrotra, Jordan Feld, Raymond T. Chung, Robert J. de Knegt, Harry L. A. Janssen, Jeroen Aerssens, Jacques Bollekens, Nir Hacohen, Georg M. Lauer, Andre Boonstra, Alex K. Shalek, Adam Gehring.

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity.

Biorxiv Jan 2022. doi: https://doi.org/10.1101/2021.11.30.470634

 

Clinical Science

Hsu YC, Suri V, Nguyen MH, Huang YT, Chen CY, Chang IW, Tseng CH, Wu CY, Lin JT, Pan DZ, Gaggar A, Podlaha O

Inhibition of Viral Replication Reduces Transcriptionally Active Distinct Hepatitis B Virus Integrations with Implications on Host Gene Dysregulation.

Gastroenterology 2022 Jan 4:S0016-5085(22)00006-3.

https://pubmed.ncbi.nlm.nih.gov/34995536/ epub ahead of print. PMID: 34995536 

 

Hu HH, Jeng WJ, Pan MH, Luo WS, Chang CL, Huang YT, Su CY, Chiang CT, Jen CL, Chien YC, Lu SN, Wang LY, Huang LR, Lee MH, Liu J, Nguyen MH, Chen CJ, Yang HI.

Serum soluble programmed cell death 1 levels predict spontaneous functional cure in inactive carriers with chronic hepatitis B.

Alimentary Pharmacology & Therapeutics 2022 Jan 14.

https://pubmed.ncbi.nlm.nih.gov/35032052/ Epub ahead of print. PMID: 35032052.

 

Public Health

Lempp FA, Roggenbach I, Nkongolo S, Sakin V, Schlund F, Schnitzler P, Wedemeyer H, Le Gal F, Gordien E, Yurdaydin C, Urban S.

A Rapid Point-of-Care Test for the Serodiagnosis of Hepatitis Delta Virus Infection.

Viruses. 2021 Nov 26;13(12):2371. doi: 10.3390/v13122371. PMID: 34960640; PMCID: PMC8703323

https://pubmed.ncbi.nlm.nih.gov/34960640/

 

Su S, Wong WC, Zou Z, Cheng DD, Ong JJ, Chan P, Ji F, Yuen MF, Zhuang G, Seto WK, Zhang L.

Cost-effectiveness of universal screening for chronic hepatitis B virus infection in China: an economic evaluation.

Lancet Global Health. 2022 Feb;10(2):e278-e287. doi: 10.1016/S2214-109X(21)00517-9. PMID: 35063115

https://www.sciencedirect.com/science/article/pii/S2214109X21005179

 

Basic Science

Svicher V, Salpini R, Piermatteo L, Carioti L, Battisti A, Colagrossi L, Scutari R, Surdo M, Cacciafesta V, Nuccitelli A, Hansi N, Ceccherini Silberstein F, Perno CF, Gill US, Kennedy

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

Gut 2021 Dec;70(12):2337-2348.

https://gut.bmj.com/content/70/12/2337

 

Michelet M, Alfaiate D, Chardès B, Salvetti A, Durantel D, Lucifora J. Inducers of NF-κB pathways impair hepatitis delta virus replication and strongly decrease progeny infectivity in vitro.

JHEP Reports 2021 (in press). 

https://doi.org/10.1016/j.jhepr.2021.100415 - https://www.jhep-reports.eu/article/S2589-5559(21)00191-9/fulltext

 

Pal S, Dey D, Chakraborty BC, Nandi M, Khatun M, Banerjee S, Santra A, Ghosh R, Ahammed SM, Chowdhury A, Datta S.

Diverse facets of MDSC in different phases of chronic HBV infection: impact on HBV specific T cell response and homing.

Hepatology. 2022 Jan 9. doi: 10.1002/hep.32331. Online ahead of print. PMID: 35000202

https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32331 

 


PICKS OF THE MONTH - December 2021

Basic Science Pick(s) of the month

Álvarez EG, Demeulemeester J, Otero P, Jolly C, García-Souto D, Pequeño-Valtierra A, Zamora J, Tojo M, Temes J, Baez-Ortega A, Rodriguez-Martin B, Oitaben A, Bruzos AL, Martínez-Fernández M, Haase K, Zumalave S, Abal R, Rodríguez-Castro J, Rodriguez-Casanova A, Diaz-Lagares A, Li Y, Raine KM, Butler AP, Otero I, Ono A, Aikata H, Chayama K, Ueno M, Hayami S, Yamaue H, Maejima K, Blanco MG, Forns X, Rivas C, Ruiz-Bañobre J, Pérez-Del-Pulgar S, Torres-Ruiz R, Rodriguez-Perales S, Garaigorta U, Campbell PJ, Nakagawa H, Van Loo P, Tubio JMC. 
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture. 
Nature Communications 2021 Nov 25;12(1):6910. doi: 10.1038/s41467-021-26805-8. PMID: 34824211; PMCID: PMC8617174 https://www.nature.com/articles/s41467-021-26805-8

Wang Y, Li Y, Zai W, Hu K, Zhu Y, Deng Q, Wu M, Li Y, Chen J, Yuan Z. 
Hepatitis B Virus cccDNA Minichromosomes in Distinct Epigenetic Transcriptional States Differ in Their Vulnerability to Damage. 
Hepatology 2021 Nov 15. doi: 10.1002/hep.32245. Epub ahead of print. PMID: 34779008.  DOI: 10.1002/hep.32245 https://pubmed.ncbi.nlm.nih.gov/34779008/

Clinical Science Pick(s) of the month

Hirode, Grishma, et al.
Off-therapy response after nucleos (t) ide analogue withdrawal in patients with chronic hepatitis B: An international, multi-center, multi-ethnic cohort (RETRACT-B study).
Gastroenterology (2021).
https://www.sciencedirect.com/science/article/pii/S0016508521037239?casa_token=PiFbuWPQk74AAAAA:KecViPU11cflqoI5YcF6klHA5hCE1yG5xDaaMCK167k49nRby9ixpS-_0TZwKQ0oAeZuE_zuskk 

Liu S, Deng R, Zhou B, Liang X, Liu Z, Peng J, Chen J, Zhou Y, Guo Y, Chen Y, Li W, Shen S, Lu X, Zhao S, Liao X, Liang H, Lan Y, Hou J, Fan R, Sun J.
Association of serum hepatitis B virus RNA with hepatocellular carcinoma risk in chronic hepatitis B patients under nucleos(t)ide analogues therapy
Journal of Infectious Diseases 2021 Dec 21:jiab597. doi: 10.1093/infdis/jiab597. Online ahead of print. PMID: 34931674.
https://pubmed.ncbi.nlm.nih.gov/34931674/

Public Health Pick(s) of the month

He WQ, Guo GN, Li C. The impact of hepatitis B vaccination in United States, 1999‐2018.
Hepatology 2021 Dec 2
https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32265 

Périères L, Diallo A, Marcellin F, Nishimwe ML, Ba EH, Coste M, Lo G, Halfon P, Touré Kane C, Maradan G, Carrieri P, Diouf A, Shimakawa Y, Sokhna C, Boyer S; ANRS 12356 AmBASS Survey Study Group.
Hepatitis B in Senegal: A Successful Infant Vaccination Program but Urgent Need to Scale Up Screening and Treatment (ANRS 12356 AmBASS survey).
Hepatology Communications 2021 Dec 17. doi: 10.1002/hep4.1879. Online ahead of print. https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep4.1879  

 

READING LISTS (This month’s papers that our scholars considered to be of special interest and worth reading!)

BASIC SCIENCE

Álvarez EG, Demeulemeester J, Otero P, Jolly C, García-Souto D, Pequeño-Valtierra A, Zamora J, Tojo M, Temes J, Baez-Ortega A, Rodriguez-Martin B, Oitaben A, Bruzos AL, Martínez-Fernández M, Haase K, Zumalave S, Abal R, Rodríguez-Castro J, Rodriguez-Casanova A, Diaz-Lagares A, Li Y, Raine KM, Butler AP, Otero I, Ono A, Aikata H, Chayama K, Ueno M, Hayami S, Yamaue H, Maejima K, Blanco MG, Forns X, Rivas C, Ruiz-Bañobre J, Pérez-Del-Pulgar S, Torres-Ruiz R, Rodriguez-Perales S, Garaigorta U, Campbell PJ, Nakagawa H, Van Loo P, Tubio JMC.
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
Nature Communications 2021 Nov 25;12(1):6910. doi: 10.1038/s41467-021-26805-8. PMID: 34824211; PMCID: PMC8617174.
https://www.nature.com/articles/s41467-021-26805-8

Hernández S, Álvarez-Astudillo F, Garrido D, Prieto C, Loyola A, Villanueva RA. 2021 Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV Replication
Biomedicines 2021 Nov 16;9(11):1701. doi: 10.3390/biomedicines9111701. https://pubmed.ncbi.nlm.nih.gov/34829930/

Kim GW, Siddiqui A. Hepatitis B virus X (HBx)
Protein Expression is Tightly Regulated by N6-methyladenosine Modification of its mRNA.
Journal of Virology 2021 Dec 1:JVI0165521. doi: 10.1128/JVI.01655-21. Online ahead of print.
PMID: 34851655 
https://pubmed.ncbi.nlm.nih.gov/34851655/

Kuipery, Adrian, et al. "Immunomodulation and RNA interference alter Hepatitis B Virus‐specific CD8 T cell recognition of infected HepG2‐NTCP." 
Hepatology (2021) https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32230 

Liu H, Cheng J, Viswanathan U, Chang J, Lu F, Guo JT.
Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis
PLoS Pathogens. 2021 Nov 9;17(11):e1010057. doi: 10.1371/journal.ppat.1010057. Online ahead of print. PMID: 34752483 https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010057

Manske K, Schneider A, Ko C, Knolle PA, Steiger K, Protzer U, Wohlleber D
In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity
Viruses 2021 Nov 13;13(11):2273. doi: 10.3390/v13112273 PMID: 34835079 https://www.mdpi.com/1999-4915/13/11/2273

Rydell GE, Prakash K, Larsson SB, Skoglund C, Ringlander J, Andersson M, Castedal M, Norder H, Lindh M
Quantification of viral RNA in multiple pieces of explant liver tissue shows distinct focal differences of hepatitis B infection
Journal of Infectious Diseases 2021 Sep 17:jiab469. doi: 10.1093/infdis/jiab469. Online ahead of print. PMID: 34534318
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab469/6371942#.Ydb23BFn2QA.twitter

Sekiba K, Otsuka M, Funato K, Miyakawa Y, Tanaka E, Seimiya T, Yamagami M, Tsutsumi T, Okushin K, Miyakawa K, Ryo A, Koike K
HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA J
Hepatology 2022 Jan;76(1):53-62. doi: 10.1016/j.jhep.2021.08.010. Epub 2021 Aug 31. PMID: 34478763
https://doi.org/10.1016/j.jhep.2021.08.010

Stephenson-Tsoris S, Casey JL.2021 Hepatitis delta virus genome RNA synthesis initiates at position 1646 with a non-templated guanosine.
Journal of Virology. 2021 Dec 8:JVI0201721. doi: 10.1128/JVI.02017-21. Online ahead of print. PMID: 34878890
https://pubmed.ncbi.nlm.nih.gov/34878890/

Ting Yao, Mengjiao Lv, Siyuan Ma, Jinmei Chen, Yi Zhang, Yongsheng Yu, Guoqing Zang, Xiaohua Chen
Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo 
Microbiology Spectrum. 2021 Dec 15;9(3):e0102421. doi: 10.1128/Spectrum.01024-21. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/34908456/

Uchida T, Park SB, Inuzuka T, Zhang M, Allen JN, Chayama K, Liang TJ. Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection
Molecular Therapy Methods & Clinical Development 2021 Nov 10;23:597-605. doi: 10.1016/j.omtm.2021.11.002. PMID: 34853804; PMCID: PMC8608598. https://pubmed.ncbi.nlm.nih.gov/34853804/

Yao T, Lv M, Ma S, Chen J, Zhang Y, Yu Y, Zang G, Chen X.  2021 Hepatitis delta virus genome RNA synthesis initiates at position 1646 with a non-templated guanosine.
Journal of Virology 2021 Dec 8:JVI0201721. doi: 10.1128/JVI.02017-21. Online ahead of print. PMID: 34878890 https://pubmed.ncbi.nlm.nih.gov/34878890/

Yuan S, Liao G, Zhang M, Zhu Y, Wang K, Xiao W, Jia C, Dong M, Sun N, Walch A, Xu P, Zhang J, Deng Q, Hu R. Translatomic profiling reveals novel self-restricting virus-host interactions during HBV infection. 
Journal of Hepatology 2021 Jul;75(1):74-85. doi: 10.1016/j.jhep.2021.02.009. Epub 2021 Feb 20. PMID: 33621634.  DOI: 10.1016/j.jhep.2021.02.009. https://pubmed.ncbi.nlm.nih.gov/33621634/

Wang Y, Li Y, Zai W, Hu K, Zhu Y, Deng Q, Wu M, Li Y, Chen J, Yuan Z. Hepatitis B Virus cccDNA Minichromosomes in Distinct Epigenetic Transcriptional States Differ in Their Vulnerability to Damage. 
Hepatology 2021 Nov 15. doi: 10.1002/hep.32245. Epub ahead of print. PMID: 34779008.  DOI: 10.1002/hep.32245. https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32245?af=R


CLINICAL SCIENCE

Chen QY, Jia HH, Wang XY, Shi YL, Zhang LJ, Hu LP, Wang C, He X, Harrison TJ, Jackson JB, Wu L, Fang ZL.
Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up study
Infection, Genetics and Evolution 2021 Dec 10:105184. doi: 10.1016/j.meegid.2021
https://www.sciencedirect.com/science/article/pii/S1567134821004846?via%3Dihub

Hirode, Grishma, et al.
"Off-therapy response after nucleos (t) ide analogue withdrawal in patients with chronic hepatitis B: An international, multi-center, multi-ethnic cohort (RETRACT-B study)." 
Gastroenterology (2021).
https://www.sciencedirect.com/science/article/pii/S0016508521037239?casa_token=PiFbuWPQk74AAAAA:KecViPU11cflqoI5YcF6klHA5hCE1yG5xDaaMCK167k49nRby9ixpS-_0TZwKQ0oAeZuE_zuskk 

Kao CC, Nie Y, Ren S, Tilani N, De Costa S, Pandey RK, Hong J, Smith DB, Symons JA, Beigelman L, Blatt LM
Mechanism of Action of Hepatitis B Virus S-antigen Transport inhibiting Oligonucleotide Polymers, STOPS, Molecules
Molecular Therapy: Nucleic Acid (2022), doi: https://doi.org/10.1016/j.omtn.2021.12.013 

Lee, Hye Won, et al. "Hepatic decompensation in cirrhotic patients receiving antiviral therapy for chronic hepatitis B." 
Clinical Gastroenterology and Hepatology 19.9 (2021): 1950-1958.
https://www.sciencedirect.com/science/article/abs/pii/S1542356520312234?casa_token=ti1NcKZhQmcAAAAA:NUdSD5v1UvZh-wyu_TnjFnJUPh6KlyGpLbsXUe6LwKwhYxWoY0VjejIsjUTxbfBmoU5MDdG-oys 

Liu S, Deng R, Zhou B, Liang X, Liu Z, Peng J, Chen J, Zhou Y, Guo Y, Chen Y, Li W, Shen S, Lu X, Zhao S, Liao X, Liang H, Lan Y, Hou J, Fan R, Sun J
Association of serum hepatitis B virus RNA with hepatocellular carcinoma risk in chronic hepatitis B patients under nucleos(t)ide analogues therapy
Journal of Infectious Diseases 2021 Dec 21:jiab597. doi: 10.1093/infdis/jiab597. Online ahead of print. PMID: 34931674
https://pubmed.ncbi.nlm.nih.gov/34931674/

Mani N, Cole AG, Phelps JR, Ardzinski A, Burns R, Chiu T, Cuconati A, Dorsey BD, Evangelista E, Fan K, Guo F, Harasym TO, Kadhim S, Kowalski R, Kultgen SG, Lee ACH, Li AH, Majeski SA, Miller A, Pasetka C, Reid SP, Rijnbrand R, Micolochick Steuer HM, Stever K, Tang S, Teng X, Wang X, Sofia MJ
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein
Antiviral Research 2021 Nov 23;197:105211. doi: 10.1016/j.antiviral.2021.105211. Epub ahead of print. PMID: 34826506.
https://doi.org/10.1016/j.antiviral.2021.105211

Wang Y, Xiao X, Chen S, Huang C, Zhou J, Dai E, Li Y, Liu L, Huang X, Gao Z, Wu C, Fang M, Gao C. The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing. 
Frontiers in Immunology 2021 Nov 25;12:775461. doi: 10.3389/fimmu.2021.775461. eCollection 2021.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.775461/full 

Zhou Y, He Y, Chang Y, Peng X, Zhao R, Peng M, Hu P, Ren H, Chen M, Xu H
Frontiers in Pediatrics 2021 The Characteristics of Natural Killer Cells and T Cells Vary with the Natural History of Chronic Hepatitis B in Children. 
Nov 25;9:736023. doi: 10.3389/fped.2021.736023
https://pubmed.ncbi.nlm.nih.gov/34900857/

PUBLIC HEALTH

He WQ, Guo GN, Li C The impact of hepatitis B vaccination in the United States, 1999‐2018. Hepatology 2021 Dec 2 
https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.32265

Kikuchi M, Sawabe M, Aoyagi H, Wakae K, Watashi K, Hattori S, Kawabe N, Yoshioka K, Tanaka J, Muramatsu M, Wakita T. Development of an intervention system for linkage-to-care and follow-up for hepatitis B and C virus carriers.
Hepatology International 2021 Dec 2:1-3.
https://pubmed.ncbi.nlm.nih.gov/34855104/

Périères L, Diallo A, Marcellin F, Nishimwe ML, Ba EH, Coste M, Lo G, Halfon P, Touré Kane C, Maradan G, Carrieri P, Diouf A, Shimakawa Y, Sokhna C, Boyer S; ANRS 12356 AmBASS Survey Study Group.
Hepatitis B in Senegal: A Successful Infant Vaccination Program but Urgent Need to Scale Up Screening and Treatment (ANRS 12356 AmBASS survey). 
Hepatology Communications 2021 Dec 17. doi: 10.1002/hep4.1879. Online ahead of print. https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep4.1879


 

PICKS OF THE MONTH - November 2021

Basic Science Pick(s) of the month

Liu H, Cheng J, Viswanathan U, Chang J, Lu F, Guo JT. (2021) Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis. PLOS Pathogens 2021 Nov. 9;17(11): e1010057. doi: 10.1371/journal.ppat.1010057. Online ahead of print. PMID: 34752483. journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010057

Marchetti AL, Zhang H, Kim ES, Yu X, Jang S, Wang M, Guo H. (2021) Proteomic Analysis of Nuclear HBV rcDNA Associated Proteins Identifies UV-DDB as a Host Factor Involved in cccDNA Formation. Journal of Virology 2021 Oct. 27: JVI0136021. doi: 10.1128/JVI.01360-21. pubmed.ncbi.nlm.nih.gov/34705558/

Wang Y, Li Y, Zai W, Hu K, Zhu Y, Deng Q, Wu M, Li Y, Chen J, Yuan Z. (2021) Hepatitis B Virus cccDNA Minichromosomes in Distinct Epigenetic Transcriptional States Differ in Their Vulnerability to Damage. Hepatology 2021 Nov. 15doi: 10.1002/hep.32245. Online ahead of print. PMID: 34779008. aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32245

Clinical Sciences Pick of the Month:

Aliabadi E, Urbanek-Quaing M, Maasoumy B, Bremer B, Grasshoff M, Li Y, Niehaus CE, Wedemeyer H, Kraft ARM, Cornberg M. (2021)   Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection. Gut 2021 Oct. 26 gutjnl-2021-324646. doi: 10.1136/gutjnl-2021-324646. Online ahead of print. PMID: 34702717 gut.bmj.com/content/early/2021/10/26/gutjnl-2021-324646.long

Public Health Pick of the Month

de Villiers MJ, Nayagam S, Hallett TB. The impact of the timely birth dose vaccine on the global elimination of hepatitis B. Nature Communications 2021 Oct. 28;12(1):6223. doi: 10.1038/s41467-021-26475-6. nature.com/articles/s41467-021-26475-6

 

READING LISTS (This month’s papers that our scholars considered to be of special interest and worth reading!)

Basic Science Reading List:

Herschke F, Li C, Zhu R, Han Q, Wu Q, Lu Q, Barale-Thomas E, De Jonghe S, Lin TI, De Creus A. (2021) Antiviral Res. JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms. Oct 28;196:105196. doi: 10.1016/j.antiviral.2021.105196. Online ahead of print.

Kim C, Barnes LF, Schlicksup CJ, Patterson AJ, Bothner BB, Jarrold MF, Wang CJ, Zlotnick A. Journal of Virology (2021) Oct 27: Core Protein-Directed Antivirals and Importin beta Can Synergistically Disrupt HBV Capsids. JVI0139521. doi: 10.1128/JVI.01395-21. Online ahead of print. PMID: 34705562.

Kocher A, Papac L, Barquera R et al (2021) Ten millennia of hepatitis B virus evolution. Science. 2021 Oct 8;374(6564):182-188. doi: 10.1126/science.abi5658. Epub 2021 Oct 7. PMID: 34618559.

Kuipery A, Sanchez Vasquez JD, Mehrotra A, Feld JJ, Janssen HLA, Gehring AJ. Immunomodulation and RNA interference alter Hepatitis B Virus-specific CD8 T cell recognition of infected HepG2-NTCP. Hepatology. (2021) Nov 7. doi: 10.1002/hep.32230. Online ahead of print. PMID: 34743340. aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32230

Lin J, Li J, Xie P, Han Y, Yu D, Chen J, Zhang X. Hepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models. Virulence. (2021) Nov 5. doi: 10.1080/21505594.2021.1999130. Epub ahead of print. PMID: 34738866.

Liu H, Cheng J, Viswanathan U, Chang J, Lu F, Guo JT. Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis. PLoS Pathog. (2021) Nov 9;17(11):e1010057. doi: 10.1371/journal.ppat.1010057. Online ahead of print. PMID: 34752483. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010057

Manske, K.; Schneider, A.; Ko, C.; Knolle, P.A.; Steiger, K.; Protzer, U.; Wohlleber, D. In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity. Viruses (2021), 13, 2273. https://doi.org/10.3390/v13112273

Mao, R., Dong, M., Shen, Z., Zhang, H., Liu, Y., Cai, D., ... & Guo, H. (2021). RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation. Journal of Virology, 95(19), e00444-21. https://journals.asm.org/doi/abs/10.1128/JVI.00444-21 

Marchetti AL, Zhang H, Kim ES, Yu X, Jang S, Wang M, Guo H. Proteomic Analysis of Nuclear HBV rcDNA Associated Proteins Identifies UV-DDB as a Host Factor Involved in cccDNA Formation. J Virol. (2021) Oct 27:JVI0136021. doi: 10.1128/JVI.01360-21.

Uchida, Takuro; Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn N Allen, Kazuaki Chayama, T Jake Liang. Genetically Edited Hepatic Cells Expressing the NTCP-S267F Variant are Resistant to Hepatitis B Virus Infection. (2021) Molecular Therapy, Cell Press, Nov https://doi.org/10.1016/j.omtm.2021.11.002.  

Wang Y, Li Y, Zai W, Hu K, Zhu Y, Deng Q, Wu M, Li Y, Chen J, Yuan Z. Hepatitis B Virus cccDNA Minichromosomes in Distinct Epigenetic Transcriptional States Differ in Their Vulnerability to Damage. Hepatology. (2021) Nov 15. doi: 10.1002/hep.32245. Epub ahead of print. PMID: 34779008.  DOI: 10.1002/hep.32245.

Yuan S, Liao G, Zhang M, Zhu Y, Wang K, Xiao W, Jia C, Dong M, Sun N, Walch A, Xu P, Zhang J, Deng Q, Hu R. Translatomic profiling reveals novel self-restricting virus-host interactions during HBV infection. J Hepatol. (2021) Jul;75(1):74-85. doi: 10.1016/j.jhep.2021.02.009. Epub 2021 Feb 20. PMID: 33621634.  DOI: 10.1016/j.jhep.2021.02.009.

 

Clinical Sciences Reading List

Aliabadi E, Urbanek-Quaing M, Maasoumy B, Bremer B, Grasshoff M, Li Y, Niehaus CE, Wedemeyer H, Kraft ARM, Cornberg M. Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection. (2021) Gut. Oct 26:gutjnl-2021-324646. doi: 10.1136/gutjnl-2021-324646. Online ahead of print. PMID: 34702717 Free article. https://gut.bmj.com/content/early/2021/10/26/gutjnl-2021-324646.long

Gupta SV, Fanget MC, MacLauchlin C, Clausen VA, Li J, Cloutier D, Shen L, Robbie GJ, Mogalian E. Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection. Drugs R D. 2021 Dec;21(4):455-465. doi: 10.1007/s40268-021-00369-w.

Hirode G, Choi HS, Chen CH, Su TH, Seto WK, Van Hees S, Papatheodoridi M, Lens S, Wong G, Brakenhoff SM, Chien RN, Feld J, Sonneveld M, Chan HL, Forns X, Papatheodoridis GV, Vanwolleghem T, Yuen MF, Hsu YC, Kao JH, Cornberg M, Hansen BE, Jeng WJ, Janssen H; RETRACT-B study group. Off-therapy response after nucleos(t)ide analogue withdrawal in patients with chronic hepatitis B: An international, multi-center, multi-ethnic cohort (RETRACT-B study). Gastroenterology. (2021) Nov 8:S0016-5085(21)03723-9. doi: 10.1053/j.gastro.2021.11.002. Epub ahead of print. PMID: 34762906.

Kumada T, Toyoda H, Yasuda S, Ito T, Tanaka J. Mortality of inactive hepatitis B virus carriers in Japan is similar to that of the general population. Hepatol Res. (2021) Oct 19. doi: 10.1111/hepr.13723. Epub ahead of print. PMID: 34665918.

Lang-Meli, J., Neumann-Haefelin, C., & Thimme, R. (2021).  Immunotherapy and therapeutic vaccines for chronic HBV infection. Current Opinion in Virology, 51, 149-157. https://www.sciencedirect.com/science/article/abs/pii/S1879625721001243 

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Public Health Reading List

Bhanu C, Gopal DP, Walters K, Chaudhry UA. Vaccination uptake amongst older adults from minority ethnic backgrounds: A systematic review. PLoS medicine. 2021 Nov 4;18(11):e1003826

Chang KC, Chang MH, Chen HL, Wu JF, Chang CH, Hsu HY, Ni YH. J Infect Dis. 2021 Online ahead of print.  Universal Infant Hepatitis B Virus (HBV) Vaccination for 35 years: moving toward the Eradication of HBV.  Aug 7:jiab401. doi: 10.1093/infdis/jiab401.  https://pubmed.ncbi.nlm.nih.gov/34363469/

de Villiers MJ, Nayagam S, Hallett TB. 2021 The impact of the timely birth dose vaccine on the global elimination of hepatitis B.  Nat Commun. Oct 28;12(1):6223. doi: 10.1038/s41467-021-26475-6. 

Ioannou, George N. 2021 Epidemiology and risk-stratification of NAFLD-associated HCC Published: Aug. 25, 2021DOI:https://doi.org/10.1016/j.jhep.2021.08.012

Klok S, van Dulm E, Boyd A, Generaal E, Eskander S, Joore IK, van Cleef B, Siedenburg E, Bruisten S, van Duijnhoven Y, Tramper-Stranders G, Prins M. Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) infections among undocumented migrants and uninsured legal residents in the Netherlands: A cross-sectional study, 2018-2019. PLoS One. 2021 Oct 29;16(10):e0258932. doi: 10.1371/journal.pone.0258932.

Kumada T, Toyoda H, Yasuda S, Ito T, Tanaka J. 2021 Mortality of inactive hepatitis B virus carriers in Japan is similar to that of the general population.  Hepatol Res. 2021 Oct 19. doi: 10.1111/hepr.13723. Online ahead of print.

Pattyn, J., Hendrickx, G., Vorsters, A., & Van Damme, P. (2021). Hepatitis B Vaccines. Journal of infectious Diseases, 224(Supplement_4), S343-S351. https://academic.oup.com/jid/article/224/Supplement_4/S343/6378091?login=true 

Santos PMG, Dee EC, Deville C. Confronting Anti-Asian Racism and Health Disparities in the Era of COVID-19. JAMA Health Forum. 2021;2(9):e212579. doi:10.1001/jamahealthforum.2021.2579

Terrault NA, Wahed AS, Feld JJ, Cooper SL, Ghany MG, Lisker-Melman M, Perrillo R, Sterling RK, Khalili M, Chung RT, Rosenthal P, Fontana RJ, Sarowar A, Lau D, Wang J, Lok AS, Janssen H.  Incidence and Prediction of HBsAg Seroconversion in a Prospective Multi-ethnic HBeAg-Negative Chronic Hepatitis B Cohort.  Hepatology. 2021 Nov 7. doi: 10.1002/hep.32231. Online ahead of print.

Wang Q, Xiu S, Yang L, Han Y, Huang J, Cui T, Shi N, Liu M, Wang X, Lu B, Jin H, Lin L. Delays in routine childhood vaccinations and their relationship with parental vaccine hesitancy: a cross-sectional study in Wuxi, China. Expert Rev Vaccines. 2021 Nov 18. doi: 10.1080/14760584.2022.2008244.