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LiverCancerConnect

Liver Cancer Drug Watch

Compounds in Development for Liver Cancer

Updated January 2024

Drug Name 

Mechanism 

Company

Company Website

USA Status

Clinical Trial Website

Nexavar (Sorafenib) 

Raf/Mek/Erk inhibitor

Bayer

nexavar-us.com

Approved

N.A.

Keytruda(Pembrolizumab)

PD-1 checkpoint inhibitor

Merck

keytruda.com

Approved for use after treatment with sorafenib (Nexavar)  N.A.
Opdivo (Nivolumab) + Yervoy (Ipilimumab) CTLA-4-blocking antibody + PD-1 checkpoint inhibitor Bristol-Myers Squibb  opdivo.com/advanced-hcc Approved for combination use after treatment with sorafenib (Nexavar) N.A.

Stivarga (Regorafenib) 

Raf/kit/ret kinase inhibitor

Bayer

stivarga.com

Approved

N.A.

Opdivo (Nivolumab) 

PD1 inhibitor

Bristol Myers-Squibb

opdivo.com

Approved

N.A.

Lenvima (Lenvatinib) 

VEGFR, PDGFR, FGFR, RET and c-Kit inhibitor

Eisai

lenvima.com

Approved

N.A.

Cabometyx (Cabozantinib) 

VEGFR2, c-MET, RET, KIT, FLT4, AXL inhibitor

Exelixis

cabometyx.com

Approved

N.A.

Tecentriq (Atezolizumab) + Avastin (Bevacizumab) 

PD-L1 monoclonal antibody/VEGFA inhibitor

Genentech

tecentriq.com

Approved

N.A.

Cyramza (Ramucirumab) 

VEGFR2 inhibitor

Eli Lilly and Co.

cyramza.com

Approved

N.A.

Imjudo (tremelimumab) 

CTLA-4

AstraZeneca 

astrazeneca.com 

Approved

N.A. 

Imfinzi (Durvalumab) + Tremelimumab (imjudo)

PD-L1/CTLA-4 monoclonal antibody

AstraZeneca

astrazeneca.com

Phase III

Clinical Trial

Cabozantinib + Opdivo (Nivolumab) ± Yervoy (Ipilimumab) 

MET inhibitor, PD1 inhibitor, CTLA-4-blocking antibody

Exelixis and Bristol-Myers Squibb

exelixis.com

Phase I/II

Clinical Trial

Atezolizumab + , Bevacizumab + or - Tiragolumab

 

Roche

roche.com

 Phase III Clinical Trial

 

Atezolizumab + Multi-Kinase Inhibitor vs. Multi-Kinase Inhibitor (Cabozantinib or Lenvatinib) alone 

 

Roche

roche.com

Phase II

Clinical Trial

Atezolizumab + Bevacizumab or Atezolizumab alone

 

Genentech

genentech.com  Phase II Clinical Trial

 

Combinations of Atezolizumab, Tiragolumab, Bevacizumab, Tobemstomig

 

Roche

roche.com

 Phase Ib/II Clinical Trial

Combinations of Atezolizumab, Tiragolumab, Bevacizumab, Tobemstomig, Tocilizumab, TPST-1120, ADG126

 

Roche

roche.com

 Phase Ib/II Clinical Trial

Cabozantinib + Tecentriq (Atezolizumab) vs. Nexavar (Sorafenib) 

MET inhibitor + PD-L1 monoclonal antibody vs. Raf/Mek/Erk inhibitor

Exelixis

exelixis.com

Phase III

Clinical Trial

Toripalamib + Lenvatinib

PD-1/VEGFR2, VEGFR3 antibody

Shanghai Junshi Bioscience Co.

junshipharma.com

Phase III

Clinical Trial

Nexavar (Sorafenib), as adjuvant 

Raf/Mek/Erk inhibitor

Bayer

nexavar.com

Phase III

Study completed

Yiviva (YIV-906) + Sorafenib

Botanical

Yiviva Inc.

yiviva.com

Phase II

Clinical Trial

MTL-CEBPA + Sorafenib

CEBPA RNA Activator MiNA Therapeutics minatx.com

 

Phase II   Clinical Trial

 

Pembrolizumab + Nexavar (Sorafenib)

PD-1/VEGFRs, C-KIT, PDGFRB, RAF inhibitor

Roswell Park Cancer Institute and Merck Sharpe & Dohme Corp.

roswellpark.org

Phase Ib/II

Clinical Trial

Pembrolizumab + Lenvima (Lenvatinib)

PD-1/VEGFR2, VEGFR3 antibody

Eisai

lenvima.com

Phase III

Clinical Trial

Pembrolizumab + Lenvima (Lenvatinib) + TACE

 
 

PD-1/VEGFR2, VEGFR3 antibody

 
Eisai lenvima.com

 

 Phase III Clinical Trial

 

Cabozantinib + Opdivo (Nivolumab)

MET inhibitor, VEGFRs/PD-1 antibody

Exelixis and Bristol-Myers Squibb

exelixis.com

Phase II

Study completed (before resection)

Clinical Trial (with TACE)

ET140203 Artemis® T Cells  T-cell therapy Eureka Therapeutics eurekatherapeutics.com  Phase I/II

Clinical Trial (ARYA-1)

Clinical Trial (ARYA-2)

Stivarga (Regorafenib) + Pembrolizumab

VEGFRs, FGFRs, C-KIT, PDGFRs, RAF/PD-1 antibody

Bayer and Merck Sharpe & Dohme Corp.

stivarga.com

Phase II

Clinical Trial

Tremelimumab (Imjudo), Durvalumab (Imfinzi) +/- Lenvatinib (Lenvima) + TACE 

PL-L1, CTLA4, VEGF 

AstraZeneca

astrazeneca.com

Phase III

Clinical Trial

Durvalumab (Imfinzi) + Bevacizumab (Avastin)  + TACE

PL-L1, VEGF 

AstraZeneca

astrazeneca.com

Phase III Clinical Trial 

Durvalumab (Imfinzi) + Bevacizumab (Avastin) 

PL-L1, VEGF  AstraZeneca astrazeneca.com Phase III Clinical Trial

Nivolumab + Relatlimab + Bevacizumab

PD-1 small molecular inhibitor, LAG3 inhibitor, VEGF BMS bms.com Phase I/II Clinical Trial

Regorafenib + Pembrolizumab vs. TACE

VEGFRs, FGFRs, C-KIT, PDGFRs, RAF/PD-1 antibody Bayer stivarga.com Phase III Clinical Trial