The first treatment for hepatitis delta, Hepcludex, was approved in July of 2020 for prescription in the European Union. This drug binds to and inactivates the essential HDV receptors on liver cells. The long-term effects of this medication seem to be promising for controlling the virus and improving quality of life for those living with HDV. Previously, the only treatment for hepatitis delta found to be somewhat effective was pegylated interferon alpha, which acts by stimulating the body's immune system to fight the virus. A small percentage (<25%) of patients experience remission when injected weekly with this treatment over periods of 48 weeks or longer. Antiviral treatments that are effective in controlling hepatitis B have no effect on hepatitis delta, but are often recommended as part of a patient's treatment plan to control their hepatitis B. Hepcludex is likely to be approved in the US in late 2022, with approvals in more countries to hopefully follow, and two other drugs, pegylated interferon lambda and lonafarnib, are currently in the clinical trial pipeline.
For more information about Hepcludex and other promising new hepatitis delta drugs in the research pipeline, visit our drug watch page.