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Facts and Figures

In the United States, hepatitis delta is estimated to affect approximately 5% of people already living with chronic hepatitis B, correlating to less than 250,000 coinfections, and classifying it as a rare disease by the National Institutes of Health (NIH). Hepatitis B and delta coinfection is more common in certain parts of the world including Mongolia, Romania, Russia, Pakistan, the Middle East, Georgia, Turkey, Pakistan, West and Central Africa, and the Amazonian river basin. Globally 15-20 million people are thought to be affected, although a recent meta-analysis suggested there may be as many as 62–72 million coinfections. 

The risk of progression to cirrhosis, including the risk of liver cancer, liver transplant, and death is in the 70% range. 

Genotypes

There are at least 8 different types of hepatitis delta called “genotypes,” which are associated with distinct disease progression. In general, a more severe disease occurs in genotype 1 and 3, and a milder disease in genotype 2. Although a single genotype tends to dominate in an infected person, multiple genotypes can occur in those at high risk for repeated exposure to the virus.

Prevalence and Genotypes of Hepatitis D Around the World
HDV prevalence 2018 Hepatology

Wedemeyer, Journal of Hepatology, 2018

  • Genotype 1– most common and found worldwide, especially   Europe, the Middle East, North America and North Africa
  • Genotype 2 – found in Japan, Taiwan and Russia
  • Genotype 3 – found exclusively in Amazonian region of South America
  • Genotype 4 – found in Japan and Taiwan
  • Genotypes 5 - 8 – found primarily in Africa

Genotype testing for hepatitis delta is available from the Centers for Disease Control and Prevention (CDC).