Hep B Blog

Is a Cure for Hepatitis B Coming? Experts Say Yes

How far are we from finding a cure for hepatitis B? We are close, said Timothy Block, PhD, president and co-founder of the Hepatitis B Foundation and its research arm, the Baruch S. Blumberg Institute. He points out that hepatitis C, once thought to be incurable, is today cured with new combination treatments.

Image courtesy of suphakit73 at FreeDigitalPhotos.net.
Image courtesy of suphakit73 at FreeDigitalPhotos.net.

Experts believe a cure for hepatitis B will also soon be developed. And the need for a cure has never been greater, with more than 240 million people worldwide living with chronic hepatitis B, causing 1 million deaths per year from related liver failure and liver cancer.

“Treatments are available,” explained Block, “but we have become a little too comfortable with the medications that are currently approved for use.” While these drugs are effective, interferon has many side effects and daily antivirals require lifelong use. These drugs work in only half of the infected population and reduce death rates by only about 40 to 70 percent.

What will a cure look like?

The available antivirals are similar and combining them offers no advantage. They have limited effectiveness against cccDNA, the seemingly indestructible “mini-chromosome” of the hepatitis B virus that continues to produce virus particles in infected liver cells, even in people being treated. A cure, therefore, would have to destroy or silence cccDNA and provide long-term immunity. Because one-drug treatments can lead to drug resistance, a cure would almost certainly involve combination therapy, similar to hepatitis C.

With the recent advances in hepatitis B research, scientists are optimistic that another big leap in the search for a cure is possible if new complementary drugs are identified. The Baruch S. Blumberg Institute of the Hepatitis B Foundation is at the forefront of research efforts to discover such new drugs.

Blumberg scientists have played a key role in increasing understanding of the virus life cycle and are designing and developing ways to test new drugs.

Hepatitis B Foundation President Timothy Block
Hepatitis B Foundation President Timothy Block

“With our Drexel University colleagues, we are among the first, if not the only group, to identify a small molecule that inhibits hepatitis B virus cccDNA formation,” Block noted. This is significant because inhibition of cccDNA is considered essential in achieving a complete cure. Block is confident that a drug that can accomplish this will be developed.

In 2015, the Blumberg Institute licensed several of its discoveries to Arbutus Biopharma, the first company solely dedicated to hepatitis B drug discovery, and signed a three-year research agreement to work on novel approaches to developing a cure. “This unique partnership will allow us to move our discoveries more rapidly from the lab to the clinic,” Block explained.

Adding to its drug arsenal, Blumberg researchers have used computer modeling to design and produce targeted drugs against hepatitis B and liver cancer. In another innovative approach, researchers are screening plant and fungal extracts from its Natural Products Collection, donated by Merck & Co. in 2011, and have already discovered two potential drugs that are active against hepatitis B.

Getting close to the finish line

“There has never been more optimism than right now that a cure is within reach,” said Block. “This is the goal of the Hepatitis B Foundation, so we are all very excited.” Blumberg researchers are building on recent discoveries that have heightened the momentum around finding a cure for hepatitis B and liver cancer: new screening methods to search for effective drugs; new ways to treat hepatitis B using different approaches to shut down the virus; a new blood biomarker that aids in the early detection of liver cancer; and a promising drug that selectively kills liver cancer cells in animal studies.

“The years that we all have spent working towards a cure for hepatitis B have laid the groundwork for this final phase,” said Block. “We are committing everything we have, every resource at our disposal, to developing the therapies that will ultimately improve the lives of all people living with hepatitis B worldwide and ultimately relegate hepatitis B to the history books.”

Drugs currently in development at the Blumberg Institute

cccDNA Inhibitors: Blumberg is the only group to identify the first small molecule inhibitor of HBV cccDNA, which has now been made highly active and is licensed to Arbutus Biopharma for further development.

Capsid Inhibitors, “YES Kinase” Inhibitors: It is using high-throughput screens and computer modeling to design and produce targeted drugs that include capsid inhibitors for hepatitis B and “YES kinase” inhibitors for liver cancer.

Immune System Activators: It has developed a new HBV drug that works by activating an infected liver cell’s own immune system, which has been shown to be effective in animal studies.

Natural Antiviral Agents: It has screened thousands of plant and fungal extracts from our extensive Natural Products Collection and identified two new leads that show potential activity against HBV.

Comments on this blog are closed. If you have questions about hepatitis B or this blog post, please email info@hepb.org or call 215-489-4900.

896 thoughts on “Is a Cure for Hepatitis B Coming? Experts Say Yes”

  1. Living as a HVB patient, we are living in fear, we really really hope a cure treatment is discovered in soonest.
    Anyhow, many thanks for your trying.

      1. HI I am a Hep B Carrier for past 5 Years. I feel an slight annoying pain at my lower right abdomen when i sit. Im doing all my regular check ups and doctor says everything is normal. Now recently doctor advised me to take medicine named Tenofovir Disproxil every day. Any idea how effective these tablets are ??. I am 28 years old. WILL PRAY FOR YOU PEOPLE TO FIND A CURE SOON. THANK YOU

        1. Hello: Medical guidelines recommend treatment if you experience any liver damage. This is indicated by an ultrasound exam and a blood test for the liver enzyme ALT/SGPT. Your doctor has probably decided that you require treatment, and tenofovir is an excellent antiviral that is very effective in lowering viral load and reducing your risk of liver damage. Experts predict a cure will be found in the next few years, we remain optimistic! Good luck.

          1. I’ve been on Viread for 4yrs. I moved last year and the new doctor took me off of it without any explanation? I’m still off of it and contacted the physician at KCMO University that put me on it. He’s beside himself as to why the new doctor took me off of it. I asked the new doctor and all she said was I no longer need it. I wasn’t having any problems by taking it… Now the severe right rib cage pain is worse. Any suggestions for what to do. I’m several state’s away from KCMO. Also it’s caused me to have Liver Sclerosis. Any suggestions would be appreciated.

          2. Hello: We agree with your former doctor. Current medical guidelines recommend that patients can be taken off antivirals (such as tenofovir – Viread) only if they have achieved undetectable viral load (HBV DNA), normal liver function (normal ALT/SGPT liver enzyme levels and have developed hepatitis B “e” antibodies over several years. Even if you met that criteria, doctors are supposed to closely monitor patients who are taken off antivirals every three to six months to make sure they don’t have a reactivation of their hepatitis B infection, and experience liver damage and sudden increase in viral load.
            Please see a doctor as soon as possible and get your liver enzymes, viral load and “e” antigen and antibody tested to find out the state of your infection. Based on those reports, you and your doctor can determine if you need to go back on antivirals, or if you’re doing OK without treatment.
            Where do you live? The foundation offers a directory of hepatitis B experts around the world at: http://www.hepb.org/treatment-and-management/physician-directory/
            Good luck.

        2. I had been a hep B patient which lead to liver transplantation. But thank Allah I am doing well being in this great country of superb medical advancement and high level patient care. So my advise for anyone having hep B or C is to take Milk Teistle. It is cheap readily available and almost no side effect. It will reduce all your harmful hepatic enzymes such A AST ALT and Bililrubin. I have given it to so many family members and it has helped them. It is not a silver bullet to cure the symptoms but it it a lot of benifits and will slow down the scar tissue demage

          1. Hello: I am glad you are doing well. The National Institutes for Health has published fact sheets on various herbal supplements, including milk thistle. The home page is at: https://nccih.nih.gov/health/herbsataglance.htm
            and the fact sheet about milk thistle is at https://nccih.nih.gov/health/milkthistle/ataglance.htm
            The NIH reports, “Previous laboratory studies suggested that milk thistle may benefit the liver by protecting and promoting the growth of liver cells, fighting oxidation (a chemical process that can damage cells), and inhibiting inflammation. However, results from small clinical trials of milk thistle for liver diseases have been mixed, and two rigorously designed studies found no benefit.”
            Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
            The other problem is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
            We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it. Good luck.

          2. Hello: There is no cure yet for hepatitis B, however there are two very effective antivirals -– entecavir and tenofovir (Viread) and its TAF formulation that was recently approved by FDA –- that quickly reduce your viral load (HBV DNA) and your risk of liver damage. To find out the latest in new hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
            And, for an update from a recent international workshop on future hepatitis B cures, please visit: http://www.hepb.org/blog/global-researchers-brainstorm-solutions-search-cure-hepatitis-b/
            Good luck.

          3. My family members are losing their lives due to hepatitis b.
            With this article I pray and energize my hope that soon you will find the cure for Hep..God bless you guys we are mostly waiting.

          4. Hello: Milk thistle, also called silymarin, is available in most drugs stories or natural food stories.
            The National Institutes for Health has published fact sheets on various herbal supplements, including milk thistle. The home page is at: https://nccih.nih.gov/health/herbsataglance.htm
            and the fact sheet on milk thistle is at https://nccih.nih.gov/health/milkthistle/ataglance.htm
            The NIH reports, “Previous laboratory studies suggested that milk thistle may benefit the liver by protecting and promoting the growth of liver cells, fighting oxidation (a chemical process that can damage cells), and inhibiting inflammation. However, results from small clinical trials of milk thistle for liver diseases have been mixed, and two rigorously designed studies found no benefit.”
            Please keep in mind that herbal remedies and supplements are not regulated so you don’t really know for sure what is in them, and that the contents could change from one bottle to the next.
            The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
            We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
            I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver.
            Good luck.

        3. Hi Mohammed I have been diagnosed HEP B 10 years ago for some reason I was not put on treatment straight away may doctor said my body was dealing well with the virus for a long time and then I start the treatment I am glad to have read this article because I have suffer many years for this pain in my lower abdomen now I can talk to my doctor about others patients having the same syntom

          1. Just found out I have hep b, pain in my lower left and right abdomen been occurring for the past 6 months. Does this mean I’m getting worst? Also taking antiviral does that help with my pain or will pain still exist? Very hopeful for a cure for hep b coming soon. Thx for reading and answering

          2. Hello: Was this your first hepatitis B test? To know if you have chronic or acute hepatitis B, you should get tested again in six months. When healthy adults get hepatitis B, it can take up to six months to clear the infection.
            Generally, hepatitis B is known as a “silent infection” because it rarely causes pain or side effects. (See: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/)
            Medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and share your physical symptoms, they may be caused by a medical condition not related to hepatitis B. Good luck.

          3. Hello: There is no cure yet for hepatitis B, however there are two very effective antivirals–tenofovir (Viread) and entecavir–that quickly reduce your viral load (HBV DNA) and your risk of liver damage. How much these drugs cost vary widely and depend on where you live and what type of health insurance you have. Please talk to your doctor and pharmacist for more information.
            Remember that most people with hepatitis B live long and healthy lives, especially if they avoid alcohol and cigarettes. Live a healthy lifestyle, get monitored and you can live a full life. Good luck.

        4. Have been on tenofovir disoproxil for almost 10 years, I am on the generic version. I do not pay to much attention to my hbv as I do not want it to totally consume me. The only thing I noticed is that my lose of bone. Also one must never skip taking so if you miss a day resume as soon as possible.

      2. Are there any experimental research centers looking for volunteers? I got this from my x-wife who I found out, after having sex with her that she was hooked on opiates and shooting up. This virus sucks!

      3. Why do doctors wait till the liver to start damage before treatment. But not immediately when the virus is detected.

        1. Hello: Good question. For antivirals or pegylated interferon to work to lower viral load and reduce liver damage, it needs your immune system to be aware and actively fighting the infection. Without this partnership, antivirals will lower viral load, but without the immune system joining in to suppress viral replication and attack the infected liver cells, all antivirals do is temporarily reduce viral load. When you stop antivirals, your viral load will rise again because there is no immune system to suppress it.
          Also, because people often have to be on antivirals for several years, no doctor wants to put a patient on a medication that in the long run will have no impact on their infection.
          Once researchers develop other ways to cure hepatitis B — such as a mechanism to stop production of the hepatitis B surface antigen (HBsAg) that is believed to hide the virus from the immune system — then these new treatments can be applied to anyone infected with hepatitis B. They don’t have to wait until the immune system is churning out antibodies and fighting the hepatitis B-infected liver cells. Hope this helps.
          Good luck.

          1. Your answer is not enough sir.
            As long the virus is a foreign invader of the body there is need to take immediate treatment so that to stop progression. Because when it progress and weakening the immune that is why most of the patient fail not to respond to the late treatment and die. I Suggest if i were a doctor or expert I would have strat to treat the patient unknown complication of virus in the body. There are many activities that virus is doing in the body, some time immune can be overcome and weaken by a virus and it will lead the immune not to react that will let the virus
            to progress, and when the late treatment is taken then it will get the body is weak and it will not able to cooperate with the drug and fight the virus. That result to what you call as the patient is not responding to the treatment while the policy of being long without treatment has killed human immune……………. Am CHB patient and I wonder why the world neglects our suffering with such a disease which is man made virus………Anyway God is great and it will save the poor people and least developing countries who have no vaccination during childbirth.

    1. Me too i have hep b..but my problem is i want to work abroad but im afraid.or maybe they dont hired me because i have hepa b.what can i do..please kindly help me..thanks

      1. Hello: Unfortunately, some countries in the Middle East discriminate against people with hepatitis B and will not issue student or work visas to anyone testing positive for the hepatitis b surface antigen (HBsAg).
        However, countries in North America and Europe do not restrict visas based on someone’s hepatitis B status. Good luck.

        1. I have hbsag, and that’s why kuwait did not gave me work visa, I living in india.
          Can I get work visa of dubai?
          I read a article, in that article they mentioned if hbsag infected person not work in 5 categories:- nanny,saloon,food factory etc..
          And my work not fall in those categories, so can I get visa or not?

          (I’m Mechanist (lathe machine operator)

          1. Hello: According to some reports, the UAE has relaxed some of its discriminatory policies that previously barred people with hepatitis B from getting work permits. The new laws mean that visa screening tests for hepatitis B now only applies to six specified categories of applicants: nannies, housemaids, and nursery workers; hairdressing salon workers; beauty centere workers; health club workers; anyone working in processing or food-control authorities; and those in cafes and restaurants. UAE includes: Abu Dhabi, Ajman, Al Fujayrah, Ash Sharique, Dubayy, Umm Qaywayn. Here are resources for more information:
            Visas for Dubai: http://www.expatarrivals.com/dubai/visas-for-dubai
            Visas for Abu Dhabi http://www.expatarrivals.com/abu-dhabi/visas-for-abu-dhabi
            Source: http://www.thenational.ae/news/uae-news/health/uae-hepatitis-screening-rules-have-been-relaxed
            Good luck.

    2. Can you also help us. Please. ): my brother is also diagnosed with HBV. And we dont know what to do. Please help us save my brother

      1. Hello: Please keep in mind that many people infected with hepatitis B live long and healthy lives. Has your brother had his liver enzymes (called ALT or SGPT) tested? When liver cells are damaged, they release ALT/SGPT into the bloodstream. Healthy ALT/SGPT levels for men range up to 30 to 40.
        Also, he should get an ultrasound of his liver, if that is available to you.
        Treatment is not recommended unless he has signs of liver damage. Good luck.

      1. Hello sir I’m hapitise b viruse patient last one year I used tenvir medicine one year again report is coming positive what should I do I have no sygtom my hapitise is normal so his there any​ medicine to cure my hapitise b

        1. Hello: Medical guidelines do not recommend treatment with tenofovir unless you had signs of liver damage — indicated by elevated liver enzymes or an ultrasound exam of the liver that found fibrosis. Did you have liver damage and is that why your doctor began treatment? Antvirals (tenofovir) are effective at quickly lowering viral load, but it does not cure hepatitis B or make the hepatitis B surface antigen (HBsAg) disappear.
          Researchers are working hard to develop a cure for hepatitis B, and they predict in several years they will find one. Good luck.

        1. Hi,

          I have been on viread for 3 years, recently my doctor switched me to vemlidy and the medicine costs about $1000 per month. Since there is no cure for it, does it matter if I stay with Viread.

          1. Hello: As long as tenofovir (Viread) is not causing you any bone loss or kidney damage, you should talk to your doctor about switching back to Viread if you cannot afford Vemlidy. As you may know, Vemlidy (TAF) is a new formulation of tenofovir that reaches your liver cells more effectively, and consequently a lower dose of tenofovir is needed. There is less impact on your kidneys and bones with the lower dose.
            Good luck.

  2. thanks for your efforts what your estimate time for produce a HBV Cure?after how many years?

      1. Normal, ASAT, ALAT, ALP, GT,
        HBeAg NEG
        anti-HBe POS
        HBsAg POS
        anti-HBs NEG
        anti-HBc POS
        HBV-DNA 801 IU/mL.

        Is my wife test results good or bad? Is the virus high?
        What do you think about this result? Is my wifes virus to much? Or good?

        1. Hello: The results are very good for someone with hepatitis B, they show she is not experiencing any liver damage (because her liver enzyme ALT is normal) and her viral load at 801 IU/mL is low. She is doing fine, she needs to continue to eat healthy foods, and of course avoid alcohol and cigarettes. I assume you have been vaccinated against hepatitis B? Also, it is critical if and when you have children, that they are vaccinated with the first hepatitis B vaccine dose within 12 hours of birth. Good luck.

          1. Thank you so much dr!
            Yes im vaccinated!

            Do you ‘think it is possible that shes can be healthy from chronic hepatits b some day? If she take care of herself and eat healthy?

          2. Thank you so much dr!
            Yes im vaccinated!

            Do you ‘think it is possible that shes can be healthy from chronic hepatits b some day? If she take care of herself and eat healthy

          3. Hello: Keep in mind most people with hepatitis B live long and healthy lives with hepatitis B and never require treatment. She may never lose the hepatitis B surface antigen, but as long as she leads a healthy lifestyle and is monitored regularly, her risk of liver damage is low! Good luck.

    1. Hello: This blog describes what our research arm is doing, we don’t care who gets there first, we just hope a cure is developed soon. Thank you.

    2. Hello! can you avail me with any information and contact where i can help my self i have abrother who is hepataitis b positive
      REGARDS
      Patrick

      1. Hello: You will find much of the information you need at the Hepatitis B Foundation’s website at http://www.hepb.org). If he was recently diagnosed, this page might be helpful: http://www.hepb.org/prevention-and-diagnosis/newly-diagnosed/
        It is important for your brother to be monitored regularly, and I hope you have been tested for hepatitis B and vaccinated if needed yourself.
        If you live outside of the U.S., the World Hepatitis Alliance (www.worldhepatitisalliance.org) lists organizations in each country that assist and advocate on behalf of people with hepatitis B.
        Good luck.

        1. Hi good morning. good day. I’m acquire HBsag sickness so I’m going for treatment next week, I have been hearing about Tenofovir and entecavir medicines therefore how much these medicines cost?? Can you please suggest me. Thank Sir/ma’am

          1. Hello: Medical guidelines recommend treatment ONLY if you have a high viral load and signs of liver damage — usually indicated by above-normal liver enzymes (called ALT or SGPT) or by an ultrasound of your liver.
            If you do have liver damage and a high viral load, either entecavir or tenofovir is recommended and both are very good. Their costs vary based on where you live, so see which one is the most cost effective in your area. Good luck.

    1. Hello: This blog describes what our research arm is doing, we don’t care who gets there first, we just hope a cure is developed soon. Thank you.

      1. Hello, please this is the result of my brother and I need explanation whether he is in acute or chronic stage and any help.
        HEPATITIST B PROFILE RESULT
        HbsAg = positive
        HbsAb = negative
        HbeAg = negative
        HbeAb = positive
        HbcAb = positive

        THANK YOU

        1. Hello: When you test positive for the hepatitis B surface antigen (HBsAG), it means you are currently infected with hepatitis B. Most healthy adults who are infected are able to get rid of the virus on their own within six months. This is called an acute infection.
          However, if you continue to test positive for HBsAg for longer than six months, it is considered a chronic infection. It means you were probably infected at birth or during early childhood, when your immature immune system could not fight it.
          Knowing whether your hepatitis B is acute or chronic will help you and your doctor determine your next steps. Please get tested again in six months to find out if it’s chronic or acute. If you are unsure of what your blood test results mean, please visit: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
          Also, please get your brother’s liver enzyme (called ALT or SGPT) tested in a blood test to determine if the hepatitis B infection is harming his liver.
          Good luck.

  3. Surprising that an article about promising HBV cures can be written without even mentioning Arrowhead Pharmaceuticals! Rather than plowing through a lecture here from me, you’re better off going to their website, and/or reading recent EASL research papers by Drs. Locarnini and Walsh, both independent.

    Basically, even one, small dose of their ARC-520 has shown significant knockdown of ALL viral proteins (s,x,core…) produced by cccDNA. To my knowledge, they are the first to show, what was not known before, that integrated HBV DNA also produces s-antigen. They have developed ARC-521 to deal with that, and submitted an IND just weeks ago. They are currently experimenting with dose and infusion-rate to discover an optimimum.

    However, and quite aside from their HBV experiments, they seem to be the first and only company to have developed a safe and effective platform for delivering RNAi to target genes, both intra- and extra-hepatic. ARC-520 & -521 are pioneering applications of this platform.

    1. Hello: This blog describes what our research arm is doing, we don’t care who gets there first, we just hope a cure is developed soon. Thank you.

  4. Can you estimate a timeline that hepatitis-B cure(not treatment) will be developed?Thank you

      1. How i wish that this medicine will be discover soon before Hepa B carrier will die or suffered with this disease. I want to work abroad but this disease is controlling my future. It’s a waste of time when i’m applying in overseas.

  5. it’s a big news for world but all ways many researchers getting a promise but no acctual drug available so much endless promise….many patients are still dying

    1. Hello: We are as anxious for a cure as you are. Researchers are working hard to find a cure. Thank you.

      1. I have it on good authority that there is a cure. But it only works in 50% of cases . The other 50% it mutates into 2 other forms of the virus. That’s hopefull

        1. Hello: There is no cure for hepatitis B yet, however experts predict one will be developed in the next few years. If someone is experiencing liver damage, medical guidelines recommend either entecavir or tenofovir. These are daily antiviral pills that quickly reduce viral load and reduce the risk of liver damage. Good luck.

          1. Thank you for your response, And may I congratulate you on your efforts, And it has to be said a truly amazing and an exciting field you work in.Thank you all.

          2. I am 59 and had chronic hep B, my AST 26 and ALT 28 both are normal, my liver ultrasound also normal, but my HBV DNA is 24,934 UL/mL and other HBV DNA 4.39 Log IU/mL. When I woke up in the morning my right
            upper abdominal is hurting but it goes away after I did deep breathing a few times. I also had high blood
            pressure but I hardly take medication for that I like to use alternative medicine instead to control high blood pressure, like organic Moringa tea, green vegetable juice, lime juice and hot water therapy etc… For my
            liver, I drink Dandelion root tea, Bitter melon tea, organic green vegetable juice, grapefruit with garlic and olive oil smoothie, Turmeric with ginger tea, Milk Thistle, water kefir probiotic drink. I do liver cleanse with lime juice and olive oil and colonic hydrotherapy twice a year.

            My doctor wants to put me on Tenoforir or Entecovir, I’m not sure if I should get a treatment, I really don’t like to take any medication. I read the article about Tenoforir they said it may cause kidney problem. Please be
            advised if I should take this medication. Thanks

          3. Hello: Current medical guidelines do not recommend treatment unless you are experiencing liver damage, which your ALT level and liver ultrasound show you do not have.
            Perhaps you should simply continue to be monitored, at least every six months, and carefully watch both your viral load and your ALT levels for any signs of liver damage, before initiating treatment.
            Your doctor may want to start treatment because of your age, or if you have a history of liver cancer in your family.
            Hepatitis B rarely causes abdominal pain. If you are experiencing high blood pressure, I encourage you to talk about medical treatment with your doctor, as there is little clinical evidence that the herbal supplements and diet that you describe will make high blood pressure, which can be dangerous, go away.
            If you and your doctor decide on treatment for your hepatitis B, either entecavir or tenofovir are recommended, and there is a new tenofovir formulation called TAF (Vemlidy) that has less impact on kidney function. Good luck.

          4. Thank you for your fast response. I hope the cure for Hep B medication is soon ready. May God bless you and bless your team.

  6. Hi. Thank you for all ur efforts related with HBV.
    As I observe, many of responders here in this blog are within my age range; 38-40. They must be born in 70’s.
    Does Asia’s baby boomers generation more prone to CHB (like HCV/CHC baby boomers in USA) & it usually surfaces during this age, if we got from vertical or other transmissions?
    I wanna get for all my siblings to get screened, but we just living together during our childhood only. My late mother side has cancer gene, not sure related with liver. She, my grandma & granny had servical cancers. My aunt has breast. But none of father side has any type of C, but has diabetic & hypertension factors.
    Any connection on male gene?

    1. Hello: Research shows that men who have chronic hepatitis B appear to be at higher risk of liver damage and cancer than women. The female hormone estrogen appears to confer some protection against liver damage.
      Hepatitis B is widespread in Asia, primarily as a result from mother-to-child infection. For more information about Asians and hepatitis B, please visit: http://hepbunited.org/
      In fact, one in 12 Asians has hepatitis B and that rate varies based on the country. Those living with hepatitis B usually have had the infection since birth, however doctors are now more aggressively testing people for hepatitis B, and the infection can begin causing liver damage when people reach their 50s or 60s, especially if they have smoked or used alcohol.
      Remember, get screened regularly! Good luck.

  7. What would you say is the main factor that is stopping companies from developing a faster cure to HBV ? I mean, there are over 2 Billion people infected around the globe – much more than HIV- that could develop liver cancer. Isn’t that a HUGE number to target at so companies can make a BIG BIG profit?? If that isn’t a BIG market, then I don’t know what it is. Please advice.

    1. Hello: We agree that there should be more resources and effort directed to finding a cure and treating and preventing hepatitis B. Please stay hopeful and do what you can individually to help educate the public about hepatitis B.
      Thank you.

  8. Is great news for people living with hepatitis B.
    I believe it will work and work fast.

  9. HBSag+
    Anti-HBS-IGG +
    HBEAG –
    HBV envelope AB IGG+
    HBV envelope AB IGM-
    HBV Viral load 3947 IU/ml
    LTF-Normal.

    Please advice accordingly,My wife is Negative

    1. Hello: As you know, you are infected with hepatitis B (as indicated by your positive hepatitis B surface antigen (HBsAg) test. Your viral load (HBV DNA) is clearly detectable, but not very high, and with normal liver enzymes, it appears you have no signs of liver damage. Please consult with your doctor, and get monitored regularly. The frequency will be based on your age, gender, and family history of liver cancer. I hope your wife has been vaccinated, as have your family members. Good luck.

  10. Hi Dr,
    My husband is inactive hbv carrier and our baby is coming recently and he (our baby) recived first doses of vaccination. I have a question now…is there any chance that my husband transmitted hbv to our baby by coughing and sneezing near the baby or by contact my husband saliva with my baby eyes or mouth is there any chance to transmit the deasies?? Please help me

    1. Hello: The hepatitis B virus is spread only through direct contact with blood and body fluids such as semen or discharge or seepage from a wound. Saliva (unless it contains blood from a mouth injury) and sneeze discharge will not transmit the hepatitis B virus. Enjoy your baby, and make sure he is vaccinated with the second and third dose on schedule so you never have to worry about him becoming infected with hepatitis B.
      Good luck.

    2. Pls my wife is having the hbv.I have been vaccinated two dose, will I be infected when I’ve sex with her.

      1. Hello: It depends on her viral load (HBV DNA) and whether you practice safe sex (use a condom) or not. Two vaccinations may provide some protection, but it’s impossible to say if it’s enough. Once you have had your third dose, wait one or two months and get tested to see if you have enough hepatitis B surface antibodies to protect you from infection. You need at least 10 mIU/mL. Once you have that amount of antibodies, you are forever protected against infection. Good luck.

  11. does preg woman with high viral load should try to take Tenofovir on her first Trimester (recommeded by doctor) or towards end of 3rd trim?

    any complications from it? i have googled lots of sites but lack of research on it.

    1. Hello: Current medical guidelines recommend that a pregnant woman with a high viral load take antiviral during the last trimester of her pregnancy, however there have been several studies that found that tenofovir is more effective in women with high viral loads if they take it easier. Also, studies that followed women who took tenofovir over the course of their entire pregnancy did fine. If her doctor is recommending tenofovir starting early in her pregnancy, it should pose no problem, however make sure she takes is over the entire course of her pregnancy and that she is monitored regularly after she gives birth and she stops taking tenofovir. Good luck.

    2. Hello: Treating pregnant women with tenofovir is a new approach to reduce the risk that a woman with a high viral load will infect her baby. Unfortunately, women with viral loads exceeding 200,000 IU/mL risk infecting their babies, even if the newborn is given the first hepatitis B vaccine dose and HBIG (hepatitis B antibodies) within 12 hours of birth.
      To date, tenofovir has proven to be very safe and effective to greatly reduce a woman’s risk of infecting her newborn, as long as the vaccine and HBIG are administered. Current guidelines recommend treatment toward the third trimester of a woman’s pregnancy, but studies show earlier treatment with tenofovir is safe and effective, especially in women with extremely high viral loads. There are women who were taking it before they became pregnant for liver damage and took it over the entire pregnancy without any ill effects to themselves or their children. Talk to your doctor about your concerns. Good luck and congratulations!

  12. Are health professionals like Doctors who are hepatitis B carriers permitted to work in america… have a friend who has been so depressed about his fate. I also pray a cure comes up soon

    1. Hello: Yes healthcare providers infected with hepatitis B are allowed to work because all clinical data show doctors and nurses etc. DO NOT spread hepatitis B to their patients or each other. In fact the CDC and the U.S. Dept. of Justice wrote opinions clarifying that. The only restriction is on surgeons and dentists who have very high viral loads and perform procedures that carry a high risk of needle stick or sharps injuries. The guidelines recommend those doctors take antivirals to lower their viral load so they pose no risk to patients. We wish every country followed these guidelines and did not discriminate against people with hepatitis B.
      We remain optimistic that a cure is developed soon also, good luck to your friend.

  13. I pray for everyone who research for cure and wish you good luck.As a 40 y old woman with chronic hepB for 20 years this news gives me hope I may be able to see my kid grow if this cure will happen .Thank you all.

    1. Hello: We are also hoping and working for a cure. Experts predict a cure will be developed in the next few years. Take care of yourself in the meantime and keep getting monitored. Good luck.

  14. I will be very happy, if the medicine of this wicked diseases is out. Very soon.
    Am in my early 20s. My liver test are as follows;
    ALP 223.2
    ALT 37.8
    AST 41.2
    GGT 46.2
    GLOBULIN 57.3
    DIRECT BILIRUBIN 6.0
    and my viral load is as follows ;
    HBV DNA copies 1154187 cp/mL
    Hept.B virus DNA 198,314 IU/my
    Please I want to the risk at which my health is, and the food I must take to protect my liver. Thanks

    1. Hello: It appears you are still in the “immune-tolerant” stage of hepatitis B. When newborns and young children are infected with the hepatitis B virus, their immature immune systems don’t recognize or attack the hepatitis B virus. Over time, gradually their immune systems mature, recognize the virus as an enemy, and generate antibodies and attack the infected liver cells.
      Over time, you will develop the hepatitis B “e” antibody (anti-HBe) and your immune system will start fighting the infection. At that time, your viral load (HBV DNA) will decline. Until then, because treatment isn’t needed, the best thing you can do is eat nutritious, low-fat foods and avoid alcohol and cigarettes. Be sure to practice safe sex, given your high viral load, and make sure your family members are tested and vaccinated if needed. Good luck.

  15. I came to know hbsag positive last week. My alt test is wihtin limit. I did ultra sound test also. Doctor says no need to worry and prescribed tenofovir for six months. Ultra sound report says calicified granuiloma in the right lobe of liver and normal sonological appearance of liver. Pls advice.

    1. Hello: Generally, medical guidelines do not recommend treatment for hepatitis B unless you have a high viral load and have liver damage. You indicate that your liver enzyme (ALT) test shows no liver damage and the ultrasound also did not find any damage. If you live outside of the U.S. and Europe (which have their own treatment guidelines), you may want to review the World Health Organization’s hepatitis B treatment guidelines with your doctor and discuss if you require treatment. They are found at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
      Good luck.

      1. Sir, I came to know hbsag positive in August 2016. I am male. My alt test was 28. I did ultra sound test also in Aug 2016. Doctor said no need to worry and prescribed tenofovir for six months. Ultra sound report says calicified granuiloma in the right lobe of liver and normal sonological appearance of liver.

        Last week, my Hepatitis B Virs, DNA qunatitative says <20 IU/ml. Please explain what it indicates.

        1. Sir, I came to know hbsag positive in August 2016. I am male. My alt test was 28. I did ultra sound test also in Aug 2016. Doctor said no need to worry and prescribed tenofovir for six months. Ultra sound report says calicified granuiloma in the right lobe of liver and normal sonological appearance of liver.

          Last week, my Hepatitis B Virs, DNA qunatitative says <20 IU/ml. Please explain what it indicates. Doc adviced me to continue the tablet for another 3 months.

          1. Hello: If August was the first time you tested positive for hepatitis B, then you need to be tested again six months after that first test to find out if you have acute or chronic hepatitis B. When healthy adults are newly infected, their immune systems are usually able to clear the infection in six months. If an infection lasts longer, it is a chronic infection and you were probably infected when you were a newborn or child, when your young immune system wasn’t able to fight the infection.
            Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage, which your ultrasound and ALT indicate you are not. Please consult with your doctor and see if continued antiviral treatment is necessary, given your health liver reports.
            If you live outside the U.S., the World Health Organization has published hepatitis B monitoring and treatment guidelines, which you may want to review with your doctor at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
            Good luck.

    1. Hello: No one knows when a hepatitis B (HBV) cure will be developed, but researchers are optimistic that one will be found in the next few years. Hepatitis D (HDV) is a more challenging disease and researchers are only beginning the process of finding how to eradicate this hepatitis B and D coinfection. We remain optimistic. Good luck.

      1. Please do more research on Phyllanthus Niruri Herb which is used in indian Ayurved. This herb has effect to stop the effect of Hepatitis virus.

    1. Hello: Using a condom greatly reduces the risk of spread hepatitis B, but there are no guarantees. The best protection is making sure your partner is vaccinated against hepatitis B. Until then, practice safe sex as carefully as you can. Good luck.

  16. Hi, I was Hbsag Reactive since 2008. I only knew when we were required to take the test as compulsory in our school when I was in college. I’m already 28yo I’m a Registered Nurse right now. I just want to get involve for this long time of research and studies for eradication of HBV. I’m very willing to volunteer for a study purposes. If you’re just looking for someone who can participate. Count me in. I just want to contribute. God bless

    1. Eu estou usando Traduz Google para ler e responder à sua pergunta . Infelizmente, com a tradução, não tenho a certeza de sua pergunta . Você é bem-vindo para tentar novamente. Desculpa.

  17. sir. good day just want to ask if what is the real status if the person is discovered a healthy carrier of hepa B reactive?
    thank you sir.

    1. Hello: There are different terms used to describe someone who is infected with hepatitis B, but who is healthy and has a low viral load (HBV DNA) and no signs of liver damage. This condition is called “inactive” hepatitis B, or someone who has an inactive infection is called a “healthy” carrier. People with inactive hepatitis B can live long and healthy lives, however they still need to be monitored, at least once a year, to make sure the infection has not become “active” and is harming their liver. They need to be monitored for the liver enzyme ALT (also called SGPT). When liver cells are injured they release ALT into the bloodstream, and a simple blood test measures ALT in the blood. Healthy ALT levels are 30 and under for men and 19 and under for women. Good luck.

  18. Hello,
    I am a 41 y.o. female from a former Soviet Union. I have been living with HepB for 33 years. I was infected as a child through vaccination (unsterilized needle). I am monitored by my doctor through a blood test and ultrasound every 6 month. My last test as September 2016 is:
    HBV DNA is 54 IU/ML
    HBV DNA 1.73 log IU
    ALT 10 U/L
    AST 16 U/L
    I just read that after 50 to 60 there there is a possibility that the virus can become active and starts damaging the liver. Is there a way to avoid that? I try to lead a healthy life style. I don’t drink or smoke, I have a healthy weight and I excise regularly.
    I am praying that the cure will be found soon and I can see my daughters growing up.
    Thank you for all the work you are doing to save our lives. God Bless.

    1. Hello: You are doing exactly what you should as you age — getting your liver enzymes (ALT) and viral load (HBV DNA) monitored every six months and leading a healthy lifestyle. Your viral load is nearly undetectable and your ALT level is well within normal range (anything under 19 is healthy for women.) Congratulations and keep up the good work. We too are hoping for a cure. Good luck.

      1. My friend has this hepb since his child he’s around 3o he has no a active hepb and he is normal they said to him.it will disappear or stay long life can he transfer to his wife

        1. Hello: People with chronic hepatitis B (most of whom became infected at birth or during childhood), are capable to transmitting the virus to their sexual partners if they do not practice safe sex. Before your friend marries, he must have his future wife tested for hepatitis B and vaccinated with all three vaccine doses before they have unprotected sex. Direct contact with infectious blood and body fluids (including semen) can spread the infection.
          Your friend should also get tested at least once a year to see if the infection is damaging his liver.
          Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Good luck.

    2. Hello sir/maam
      Hbsag-negative
      Antihbs-negativs
      Antihbc igg-8.43 reactive
      Antihbc igm- negative
      Hbeag-negative
      Anti hbe- negative
      Is there any posibility that my hbsag becomes reactive in the future? My wife is hbsag positive
      Need your expert opinion

      1. Hello: Your test results suggest a recent hepatitis B infection (given the positive or reactive result for IgM anti-HBc.) Please see your doctor and get immediately vaccinated for hepatitis B, and please get all three doses. This may help you. Generally, when healthy adults are infected with hepatitis B, they are nearly all able to clear the infection over a six month period. However, when newborns or young children are infected, they develop long-term or chronic infections, which may have occurred with your wife.
        Please get vaccinated, and get tested again about one or two months after your third vaccine dose to make sure you have cleared the infection. Good luck.

        1. I finnished all 3 vaccines last year but the results is my anti hbc igg is reactive but my hbsag and the rest are all negative

          1. Hello: If I understand you correctly, you test positive for the hepatitis B core antibody (antiHBc), but negative for the hepatitis B surface antigen (HBsAg) and the hepatitis B surface antibody (anti-HBs or HBsAb)? When you test positive for the core antibody, it means at some point in the past you were infected with hepatitis B, probably before you were vaccinated. If you test negative for both surface antigen and antibody, it may mean that your immune system was never able to completely eradicate the infection. It was able to suppress the surface antigen, but it hasn’t generated enough surface antibodies to be picked up by a lab test.
            I recommend you get tested again in a few months for the surface antigen and antibody, and also for HBV DNA (also called viral load), to make see if your have any hepatitis B virus in your body. There are some mutations that allow hepatitis B to exist, without generating the surface antigen. A viral load test can rule that out. Good luck.

          2. Can you pls explain more specific the difference of anti hbc igm and anti hbc igg? Because i am only reactive on anti hbc igg not anti hbc igm thank you in advence

          3. Hello: Hepatitis B core antibodies (anti-HBc Ab) appear shortly after a hepatitis B infection and soon after the appearance of hepatitis B surface antigen (HBsAg). Initially, core antibodies are almost entirely of the IgM class, and so this indicates a new infection. Over time, the core antibodies develop into the IgG class. These tests do not distinguish between a chronic or acute infection, you still need to be tested over a six-month period to determine what type of infection you have. Good luck.

            The anti-HBc total antibodies test, which detects both IgM and IgG antibodies, and the test for anti-HBc IgM antibodies may be the only markers of a recent hepatitis B infection detectable in the “window period.” The window period begins with the clearance of HBsAg and ends with the appearance of antibodies to hepatitis B surface antigen (anti-HBs Ab). Anti-HBc total Ab may be the only serologic marker remaining years after exposure to hepatitis B.

  19. Is antihbs 72 Iu/ml means, shall my wife is protected from hepatitis b for life long? Any booster doses reqiired for it? Becoz iam hepatitis b cqrries.

    1. Hello: Yes, she has immunity against hepatitis B. Medical guidelines say that as long as you have at least 10 iu/ml of hepatitis B surface antibodies (anti-HBs) then you are protected for life against infection. Good luck.

  20. Hello.I am hoping too much to get a cure very soon.My husband has been diagnosed with chronic active hep B four years ago. He is 32 years. He has a very low viral load all the time, every time we do the exam, about 3.56 x 10 Ui/ml. But he has high levels of ALT,4-5 time more than the normal level. On echography there are no demages.on elastography he is F1 from the begining. Our doctor has recomended interferon treatment but we are afraid of side-effects. Antivirals should be taken lifelong. So he is reciving no treatment hoping everyday that passes to find the cure, but we are living with fear. What is your opinion, should we try interferon or wait.
    Thank you

    1. Hello: You have summarized well the pros and cons of interferon vs. antivirals. The advantage with interferon is you need treatment for a limited time, six to 12 months, and there is a chance of clear the infection, though it remains low. The drawback is interferon causes side effects such as flu-like symptoms, depression and fatigue and is administered through a weekly shot. The people who do best on interferon have certain hepatitis B genotypes (viral strain). Antivirals quick lower viral load and reduce the risk of liver damage, but you’re right your husband is young, and once you start on antivirals it is unclear when, if ever, you can stop. If you can afford interferon, and if he has the right genotype, interferon is a good first choice. Please talk to your doctor, especially about genotype testing. If he opts for interferon, the doctor should measure his hepatitis B surface antigen in the early weeks of treatment. A decline in HBsAg shows the treatment may succeed. Good luck.

      http://www.hepb.org/treatment-and-management/treatment/

  21. Ever since I’m on treatment with Tenofovir 3 years now, my HbsAg levels have been rising. It has more than doubled since , from 1200 Iu/ML to 2868 Iu/ML on my latest results. Why is it rising? Should it not suppose to go on a downward trend, since I’m being treated? I’m e-negative. Second question: Which genotype is more favorable to pegylated interferon treatment and is it worth the try on e-negative patients, if I’m very much willing to go through all the side effects? Thank you.

    1. Hello: Hepatitis B genotype A is considered the most responsive to pegylated interferon treatment. I am sorry to hear about your HBsAg increase, though it is not unusual for HBsAg levels to fluctuate over time. The key indicator is whether your viral load has remained undetectable and whether your liver enzymes (ALT/SGPT) have remained in the healthy range. Good luck.

  22. I have newly infected hep b and did not care this is such serious disease. So I became chronic hep b. I deeply hope one day completely cured. All the best wishes and success for you. Please save all people with this infection.

      1. May God be with you and open your mind to shorten to the sufferers from the miserable virus. Thank you God Almighty for not neglectind me with my sinful nature.

        1. Hello: Hepatitis B is not a sin, one in three people worldwide have been infected. It is simply an infection that must be monitored. Good luck.

    1. Hello: The majority of people living with chronic hepatitis B live long and healthy lives, especially if they eat healthy foods and avoid alcohol and cigarettes. It is important that you have your liver health checked regularly by a liver specialist. If you ever experience liver damage and a high viral load, then there are effective medications, including the antivirals tenofovir and entecavir, that are very effective at reducing your risk of liver damage. Good luck.

      1. My brother is infected with hb virus.what is the best medicine can he take to control the disease? He has all the symptoms. Pease your advice will be very appreciative. As where he his they’re not familiar with the disease. Please reply

        1. Hello: Keep in mind that not everyone with hepatitis B require treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Consult with his doctor and see what his ALT levels are to determine if he requires treatment. If he does, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir. Good luck.

      2. Yes, I agree! I used to have Chronic HBV carrier. Eating clean diet is very important, and take extra vitamin C. Thanks God! I’m now free of HBV

        1. Is there a cure on it already? 16 yrs ago i was diagnosed of this dse… and im afraid to have a test again… no symptoms experienced. Is there a possibility that once u have a chronic hep b, you’re body will be free from the virus? Tnx..

          1. Hello: There is no cure for hepatitis B, but there are effective antiviral treatments that can reduce liver damage and viral load if you are experiencing liver damage (with elevated ALT/SGPT liver enzymes).
            Hepatitis B rarely causes symptoms, which is why it’s called the silent infection. It is important for you to be monitored regularly, at least once a year, to make sure the infection is not causing any damage. Good luck.

  23. Good day! Tell me is there any chance that hepatitis b will be fully curable? How many years do you think will be required for the invention of drugs against Hepatitis b? How are the trials of your drug? What to expect from him? Will it help to get rid of the hepatitis b virus?

    1. Hello: Great questions. There is no complete cure for hepatitis B yet, though researchers predict one should be developed in the next few years. Meanwhile, there are very effective antiviral treatments — either tenofovir (Viread) or entecavir — available to reduce viral load and liver damage. For information about new drugs in development, please visit our Drug Watch page at http://www.hepb.org/treatment-and-management/drug-watch/
      Thank you.

      1. My liver is in normal range and my viral load is 194iu and my doctor put on viread for 4months pliz help me is there any effect on that because I passed through the conversation and found myself on wrong …..am in Africa

        1. Hello: Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment or should continue treatment. Good luck.

  24. Sirs
    I am concerned my hbsag level of 4900 is going to give me Hcc as this is high I think.I was diagnosed 23yrs ago. Probably born with it. Hbvdna 64, never in all tests has it been higher than 500. alt 36, AFP 1.3. All lft’s normal. I have no liver damage & never been on treatment am I safe from hcc? My doc says I will die with not from & is not concerned about my hbsag level given all my information over long term tests. Your advice would be appreciated. I am 67yrs old.
    Please help

    1. Hello: It sounds like you have a good doctor who is monitoring you regularly for liver damage. As we age, however, it’s important to get screened for liver cancer regularly. Please read this overview about liver cancer screening at: http://www.hepb.org/blog/boost-liver-cancer-awareness-reduce-risk-hepatitis-b-related-liver-cancer/
      You may want to share it with your doctor to make sure you are getting the tests you need given your AFP and ultrasound exams. Good luck.

        1. Hello: Hepatitis B does not cause HIV infection, these are two separate viruses, though they are both transmitted by direct contact with blood and body fluids. Good luck.

    1. Hello: The best thing to do is to be vaccinated against hepatitis B. There is a very safe and effective vaccine available. If you are asking how to take care of yourself once you are infected in order to prevent liver damage, the best things to do is eat healthy food and avoid alcohol and cigarettes. Good luck.

  25. I have sent 2 emails with no replies, not sure I am sending correctly.
    67yrs old. Hbsag 4900, e-ant-, anti hbe+, alt 36, fibroscan 4.8,AFP 1.3. All lft’s normal. Hbvdna 64 never higher than 500. U/sound normal. Had 3 monthly tests when first diagnosed.

    Diagnosed 23yrs ago but could have had at least 20/25 yrs before or even born with.
    Any comments welcome especially on how levels fluctuate daily so could I be receiving liver damage, irrespective of my results.

    1. Hello: I’m sorry you have not received any response. At your age, it is important for you to be monitored regularly, especially for viral load (HBV DNA) and for liver damage through a blood test for the liver enzyme ALT, which liver cells release when they’re damaged.
      Your ALT is 36, depending on what your lab’s normal range is, usually a healthy ALT range is 30 or less for men and 19 or less for women.
      Given your age, and considering how many decades you have been infected, you should be monitored regularly, consult with your doctor for what the best schedule is. It is great news that your liver is in such good shape!
      Good luck.

      1. I have been considering a second opinion with another hepatologist, but, given all the information i have given you do you think annual checks are sufficient if age is a concern. As I said my doc said he thinks I will die with not from Hbv. & not develop any liver problems.Would you suggest I seek a second opinion or are you happy with my docs annual checks.
        Many thanks

        1. Hello: If you are worried, talk to your doctor about monitoring you every six months, given your age and the number of years you have been infected. Every region has its own medical guidelines dictating monitoring, however many doctors say current guidelines are not adequate in monitoring for liver cancer in at-risk individuals. Please read this blog about liver cancer monitoring which will provide more information: http://www.hepb.org/blog/your-doctor-not-screening-you-for-liver-cancer-time-for-a-talk/
          Thank you.

      2. Sirs
        Your comment of I should be monitored regularly, question is, how regularly. My doc says yearly is sufficient. Your comment has scared me, as I said in a previous comment which does not appear to have been received by you, doc says there are no medical grounds to see me more frequently. My doc says I will die with not from.
        I am frightened it will mutate or replicate but again doc says no given my overall test results & information & long term follow up with no disease progression.
        What does age & infectivity length mean, is it high risk.
        I have asked my doc for a second opinion, do you think this is a good idea? Thanks

        1. Hello: If you have no signs of liver damage, which your doctor has indicated you do not, then annual checkups as he recommended are fine. Try not to worry, continue to lead a healthy life, avoiding alcohol and cigarettes. Good luck.

      3. My lab alt ranges are 10-50.
        Will this eventually kill me or as my doc says will I die with not from, is that a real possibility.
        Not even develop any liver disease.

        1. Hello: I will assume you are infected with hepatitis (positive for HBsAg). ALT is an enzyme that liver cells release when they are damaged. Healthy ALT levels range for men are up to around 30 or 40 (each lab has its own healthy ranges) and for women they are up to about 19. If your ALT levels have ranged from 10 to 50, it appears your liver is fairly good shape. As your doctor indicated, you are in good shape. Enjoy.

  26. Hi,

    God Bless You and Thank You for what you do. I am male 40 y.o. and a Hep B carrier, I don’t know since when, I just found out 15 year ago that I have Hep B, am originally from Asia. I have a regular doctor that monitors me since 2010, everything looks good on all the blood test since 2010 but beginning this year my virus went up as high as 120 million but all the the liver scan/ultrasound shows no liver damage, I saw my doctor yesterday and she said it’s time for me to take medication, I told her that I’ve never had any health issues, everything’s the same on my body, but she insisted that since my virus is too high I needed medication. My problem is, she I am going to take this medicine for the rest of my life, she said Baraclude is good for me. I am reading about this medicine and I am scared of the side effect, especially I have Polycystic Kidney Disease (PKD), and taking Baraclude “forever” might not good for me. Right now I am healthy as normal person, I played almost any kind of sports, I run fast, ice skate, skii, etc. I feel so healthy and I am just scared that if I take this medicine I won’t be able to do what I am doing right now. I told her I’ll think about it and come back in 3 months with the decision about taking this medicine. What should I do, please advice.

    Thank You!

    HepB_Fighter

    1. Hello: I know it is overwhelming to begin a medication that you may have to take indefinitely. I assume you are still in the “immune-tolerant” stage and positive for the hepatitis B e antigen (HBeAg)? Because of your gender and age, your doctor is concerned about your continued high viral load, even though your liver appears healthy. A high viral load over time is a risk factor for liver cancer. While entecavir (it’s available as a generic now, which should make it more affordable), can affect kidney function, a lower-dose antiviral formulation, called tenofovir alafenamide (TAF), may have less impact on kidneys. TAF is now pending before the FDA and may be available in a year.
      Also, experts predict that in a few years a cure will be developed for hepatitis B, so hopefully you are not facing a lifetime of antiviral treatment.
      Keep up your healthy lifestyle and keep talking to your doctor as you research your decision. Good luck.

  27. Iam 27y o and my viral load more than 170’000’000 and Doctor says my liver is in good condition. He says I would use enticariar 0.5 mg for one year. Was my life is in danger ?thanks for ur efforts and God bless u.

    1. Hello: It is not unusual for young adults who were infected at birth to remain in the “immune-tolerant” stage until their 30s or 40s. Your immune system is basically “tolerating” the infection and doesn’t know to start attacking it by generating antibodies and attacking the infected liver cells. As a result, your liver appears healthy because the infected cells are not being attacked by the immune system at this time. However, at some point your immune system will become activated and start fighting the infection. That is why it is important that you are monitored regularly, and treated with an antiviral such as entecavir if you ever had evidence of liver damage. Good luck.

  28. Hi,sir if one got Hbs virus and on the same day he did his screening and got vaccinated for his. As this sound pretty that vaccination prevent it from incubation period or the virus gets kill during incubation period after get vaccinated

    1. Hello: Medical guidelines recommend that if you are exposed to the hepatitis B virus, one should immediately receive a dose of HBIG (hepatitis B antibodies) and the first dose of the three-dose vaccine, to spur your immune system to generate protective antibodies. You should be tested for the hepatitis B surface antigen and antibody, and also finish the hepatitis B vaccine series. Good luck.

    1. Hello: Please see my other response to your email. Generally treatment is recommended if you are experiencing liver damage and have a high viral load. Your doctor started you on treatment because he had concerns about your viral load. Please talk to him if you have questions. Good luck.

  29. Hi,
    300mg of tenofovir is normally what everyone takes. To my understanding, there are no tests done to date to confirm if 300mg is the right amount for hep b. Dosage tests on tenofovir were only done for hiv, not hep b. Question is: would there be any risk if one takes or reduces his dosage to 200 mg instead of the usual 300mg. In my opinion, if 200mg is more than suffcient, then why take a risk taking 300mg which may affect the bones and kidney health. Thank you.

  30. Dr I only wanted to no if it’s too early for
    Me to be treated with tenofovir or it’s ok
    With a viral load Of 18000 at age of 27
    2.also wanted to no per my age and viral
    Load could I have acquired the virus at
    Birth or not

    1. Hello: If you have tested positive for the hepatitis B surface antigen (HBsAg) for longer than six months, it means you have a chronic infection and were probably infected at birth or during early childhood. Have your parents or siblings been tested and vaccinated?
      Generally, medical guidelines recommend treatment only if you have a high viral load AND liver damage, indicated by elevated liver enzymes. A blood test for the enzyme ALT (also called SGPT) can find out if you are experiencing liver damage. Please talk to your doctor if you have questions. If you have no signs of liver damage, medical guidelines would probably not recommend treatment. If you live outside of the U.S., you can review the World Health Organizations for hepatitis B monitoring and treatment with your doctor at http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
      Good luck.

  31. Good day, please tell me when approximately what year will be completed of the study drugs ARC 520 ARC 521? Is there any hope that they will be able to defeat the Hepatitis b virus and fully recover? Whether these drugs to relieve the patients from HBSAg in the blood?

  32. yes may GOD bless you all for the hard work.
    but you know we are living with great fear
    i think what you have to help us how to manager and control mean while we shall be waiting for the drags thank.
    jimmy

    1. Hello: It is hard to live with a chronic disease like hepatitis B, but the best thing to do is to lead a healthy lifestyle, avoid alcohol and cigarettes, practiced safe sex and make sure your family members are tested and vaccinated if needed. Good luck.

  33. Good day, Please these are my test results:
    1.HBsAg POSITIVE
    2.HBsAb NEGATIVE
    3.HBeAg POSITIVE
    4.HBeAb POSITIVE
    5.HBcAb POSITIVE

    What does this mean and what to I do. I will appreciate your promptly response. Thank you for great work

    1. Hello: Your hepatitis B surface antigen (HBsAg) positive test shows you are currently infected with hepatitis B. Is this the first time you have been tested for hepatitis B? Your other test results are a bit confusing. The core antibody (HBcAb) test confirms you have been infected. It appears you test positive for both the “e” antigen and antibody. This can mean the “e” antibody is waging a battle against the “e” antigen and they are equally matched at the moment.
      When healthy adults are infected with hepatitis B, they are usually able to clear the infection over a six-month period. This is called an acute or short-term infection. It is impossible to know if someone has an acute or chronic infection, which lasts longer than six months, until they are tested over a six-month period. If they continue to test positive for the hepatitis B surface antigen (HBsAg) for longer than six months, it means they were probably infected at birth or during early childhood and have a chronic infection.
      Please get tested again in six months to find out if you are still infected. Also, you should have your liver enzymes (called ALT or SGPT) tested to find out if the infection is harming your liver. Good luck.

      1. Thanks for your prompt reply. My previous test was taken more than a year ago. I recently took another test and I still tested positive for the virus though I am yet to get feedback on the more detailed results. Does this mean that I am a chronic carrier? Will appreciate your feedback. Thanks.

        1. Hello: Yes, if you test positive for the hepatitis B surface antigen (HBsAg) for longer than six months, it means you have chronic hepatitis B. Please make sure you get a blood test for the liver enzyme ALT (also called SGPT) and an ultrasound to get a baseline picture of your liver health, and get monitored regularly. Also, of course eat healthy foods and avoid alcohol and cigarettes. Good luck.

  34. Hi
    I am recently diagnosed with Hepatitis B.My doctor recommend start treatment with Tenofovir. I am not very certain which medication has better respond,Tenofovir and (Peginterferon alfa-2a) or Entecavir.

    1. Hello: They are very different medications. Tenofovir disoproxil (Viread) and entecavir are antiviral pill taken once a day, with few side effects, for at least one year or longer. They work by stopping the virus from reproducing, but they work only for as long as you take it. Either drug is considered a first-line treatment and do not cause any drug resistance.
      Pegylated Interferon (Pegasys) is given by injection once a week usually for 6 months to 1 year. The drug can cause side effects such as flu-like symptoms and depression. However, in some people it is able to strengthen the immune system and help them fight the virus and achieve. You have excellent options. Good luck.

  35. You are doing great work. I was diagnosed with hbv about 7 years ago. As of 3 months ago my alt is 12 and ast 29. Is that a good value? Also I noticed pain under my rib cage, bitter mouth and yellow urine. Does these have anything to do with hbv?

    1. Hello: You have a great result. As you know ALT tests indicate if you are experiencing liver damage. A healthy ALT level for men is up to 30 and for women it’s up to 19, so you are in great shape.
      Usually, hepatitis B is a silent infection and causes no symptoms. Please contact your doctor to see if another medical condition is causing those symptoms. Good luck.

  36. Hello hbsag count of me is 6000. Is any possibility Affect my Wife during during sex. if first dos of hvb vaccinated Any possibility ട്ടോ affect her

    1. Hello: Yes, you could easily infect her if she has received only one dose of the immunization. To be fully protected against hepatitis B, a person must be vaccinated with all three doses of the hepatitis B vaccine over a six-month period. About one or two months after the third dose, she should be tested to make sure she has enough antibodies (at least 10 iu/ml) to protect her. Until that time, you should practice safe sex.

  37. I done unprotected sex.i met lot of illness from that sex.like that weight loss,lose of appetite, constipation, swollen lymph ( not now ), red eye and light fever in night, dry skin with low sense, light head ache.iritating tongue ,neck and throat. I’m fear with symptoms.but I tested with Hiv card test and Rna Pcr test on 93rd days after unprotected sex.it was No hiv rna detected and negative card test. I’m with fear. Is it possible to turn positive? Please help me

    1. Hello: There are different types of HIV Tests, and each type has a different window period before it shows an accurate result. A test taken at least three months after exposure provides highly accurate results. I encourage you to contact your doctor and see if your symptoms can result from other medical conditions. Good luck.

    2. Please let all help ourselves to discuss about our health of the hepatitis b.let all of us come together and see if we can help each other wholes we are still praying for cure to come quickly.so I have suggested to creat a WhatsApp group for we hepatitis b patient’s so we can encourage our selves.if you are interested about this suggestion please WhatsApp this number233576021846 with your name as well so I can add you into the group please.thank you

  38. Why so many year talking about cure for hepatitis b ? Untill now there is no effective drug or cure for hepatitis b …

    1. Hello: You are correct, while there are very effective antivirals that lower viral load and the risk of liver damage, there is no complete cure yet. However, experts do predict a cure will be developed in the next few years. If you want to stay up-to-date about drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
      Good luck.

  39. Is there any other drugs to keep your liver safe if you are positive hep b thank you I have experience stomach problems and feels that there’s something in my lawyer right stomach l am going to have viro load count and liver function test what advice can give me also l will have typhoid text to see thank you again

    It is possible a hep b drugs will be out soon

    1. Hello: Experts predict a cure will be developed for hepatitis B in the next few years, and we remain optimistic. In the meantime, if you experience liver damage (indicated by elevated liver enzymes) and a high viral load and require treatment, there are two very effective antivirals — tenofovir (Viread) and entecavir.
      Hepatitis B, which is called the silent infection, does not usually cause any physical discomfort in the abdomen. I am glad you are consulting with your doctor to see if there is another medical condition that could be causing those symptoms. Good luck.

  40. I was diagnosed 5 years back with Hep B but my Viral level is always around 20-40. This year it was only 20
    What does that mean ? Do I really have Hep B ?

    1. Hello: You have an excellent low viral load, which represents the amount of virus (HBV DNA) in your blood. Your viral load can fluctuate over time. Doctors usually are not concerned about minor fluctuations, but if it suddenly increase 100-fold, they would be concerned and look carefully for signs of liver damage.
      No matter what your viral load, if you test positive for the hepatitis B surface antigen (HBsAg) you are considered to be infected. Good luck.

  41. Thanks for your good work and the patience in enlightening HB patients. Thanks also for the research to discover medicine for cure.
    Please why is it that world health bodies are not interested in assisting HB patients as they assist HIV patients since both of them are similar in killing patients and the drugs are expensive.

    1. Hello: We agree that all infectious diseases need to be treated, and there is much more that can be done to have HIV, hepatitis C and B advocates join forces to eradicate all of these bloodborne infections. Please do what you can to make this happen in your region! Good luck.

    2. I been diagnose last 2012 having hepa b its sad say that some of company i applying for a job will dicrimenate for having hepa b,even i want to apply for an overseas job its difficult for me to find a job.. hope that hepa b in medical will ban, im worried about the future of my son…

  42. I am a 30yrs old male, I first tested positive to the virus in March, 2016, then my hbv profile was HBsAg +, HbsAb negative, HbcAb positive, HbeAb negative, HbeAb negative, HBV viral load less than 15 iu/ml, Alt 3, I waited for the 6months time frame and repeated the HBV profile, HBsAg positive, HbsAb negative, HbeAb positive, hbeAg negative, alt 9. My questions are what are the determining factors for clearing this virus at at acute phase aside age, and what is the cut off age for the term adult. Secondly can I spontaneously seroconvert from HBsAg positive to negative, considering the fact that I have developed antibodies to the envelop antigen.. This makes me sad as I had been denied alot of international courses and jobs because of this, which I believe strongly was from an occupational hazard.

    1. Hello: I am sorry to hear about the unfair discrimination you have faced because of your hepatitis B. Your test results show you are healthy and your viral load is low. Because you have continue to test positive for HBsAg longer than six months, it probably means you have chronic hepatitis B and were infected at birth or during early childhood.
      A small percentage of people do spontaneously lose HBsAg and develop surface antibodies, especially if they have had a low viral load over many years. Please continue to take care of yourself. Good luck.

  43. Hi,
    On Oct 12, 2016 at 9.34pm I had posted a question on the correct dosage for Tenofovir. It’s been over a week now, no answer. You may have missed my post. Kindly respond . Thank you.

  44. Is any cure for hepatitis b?
    Is hepatitis b person live how many years?
    Is hepatitis b person treatment cost per month?

    1. Hello: There is no cure yet for hepatitis B, however there are two very effective antivirals–tenofovir (Viread) and entecavir–that quickly reduce your viral load (HBV DNA) and your risk of liver damage. How much these drugs cost vary widely and depend on where you live and what type of health insurance you have. Please talk to your doctor and pharmacist for more information.
      Remember that most people with hepatitis B live long and healthy lives, especially if they avoid alcohol and cigarettes. Live a healthy lifestyle, get monitored and you can live a full life. Good luck.

  45. Thank you for your response and really appreciated your great work.
    If there is no concern about the cost,which treatment will be the best option and has a better response.
    Tenofovir and (Peginterferon alfa-2a) or
    Entecavir
    Tenofovir alone

    1. Hello: Antivirals, such as tenofovir or entecavir, are pills you take daily. Generally, they have very few side effects but they are effective for only as long as you take them. So when you begin treatment, be aware that you may be taking antivirals for a prolonged period of time.
      Pegylated interferon, in contrast, works by strengthening your immune system to fight the infection. It is administered through a weekly injection and generally, you take interferon for six months to one year. There are some side effects, such as flu-like symptoms and even mild depression. Also, interferon works better in certain hepatitis B genotypes, so it makes sense to know your genotype before starting treatment. Doctors should monitor your hepatitis B surface antigen levels carefully in the first few weeks of treatment to determine if it’s working.
      Please talk to your doctor, good luck.

  46. Hello Doc,
    I found out that I am a carrier of HEPA b when i had a medical test year 2004. The doctor gave me a vaccine that was my first and last vaccine. Last July 1, 2016 I went to gastrologist and she asked me to get sgpt and ultrasound. My liver is normal, sgpt/alt(UV test acc to ifcc) 18.5 anti-hav Igm cut off value 0.105 patient value 0.022 nonreactive. HBcab cut of value 0.619 patient value0.010 outside of reference range reactive.HBeAb, HBeAg and HBsAb are non reactive. My doctor said I need to take vitamins c and e for 3 months after that I need to test sgpt.my HBsAb cut off value 0.105 patient value 0.022 my sgpt/alt is 13.2 se suggest to get a HBV DNA 73,033 iu/ml 425,052 copies/ml. I was worried because she said my hepa is silent and no need for treatment even. No need to take vitamins just eat green leaves and fruits. Doc pls help me what to do scared I can’t work abroad because of this. I want also to have a baby. I want to be cure. I’m 35 years old.

    1. Hello: I am going to assume you are female in my answer. Unfortunately, some countries do unfairly discriminate against people with hepatitis B, especially in the healthcare professions. However, countries in Europe and North America do not. I will email you directly U.S. CDC guidelines explaining that doctors with hepatitis B do not pose a health threat to their patients or coworkers. I am glad to hear you have experienced no liver damage. Because you test negative for both the hepatitis B “e” antigen and antibody, your immune system may be starting to fight the infection, and currently there may be a “stand-off” between your “e” antigens and antibodies.
      Please be assured, you can have children with hepatitis B. However, as you may know, your newborn must be vaccinated with the first dose of the hepatitis B vaccine within 12 hours of birth, and also be given a dose of HBIG. Also, if you have a high viral load, your doctor may treat you with antivirals during your pregnancy to lower your viral load and further reduce the risk of infecting your newborn. Good luck, keep eating healthy foods, avoid alcohol and cigarettes and use safe sex practices and make sure your partner is vaccinated.

    1. Hello: I’m a little confused by your report. Your viral load (HBV DNA) at 170,000 IU/mL is high. You probably test positive for the hepatitis B surface antigen (HBsAg) also. When you write that hbg is non reactive, could you mean that you have tested negative or nonreactive for HBeAg (the hepatitis B “e” antigen?) To find out if you need treatment, you need tests to find out if have any signs of liver damage (indicated by an ultrasound exam and a blood test for the liver enzyme ALT/SGPT). Please talk to your doctor and find out if those tests have been run. If you need treatment, there are two very effective antiviral options: Tenofovir (viread) and entecavir. While there is no cure yet, these are effective in lowering viral load and reducing your risk of liver damage. Good luck.

      1. Hi, ‘am 37 years old.I teasted positive for hepatitis B 4 years ago. But was told it wasn’t replicating.Some one recommended a combination of three drugs that contain silvar solution.After about 4 months I stopped taking them, I did a test and it was negative, I did 2 more test at different places and I was still confirmed to be negative and all this while my liver function test was ok. After a while I took the 3 doses of the hepatitis B vaccine. That lkwas 2 years ago..last month I was suppose to donate blood for my pregnant wife who mainwhile is negative and has also taken the 3 dose of the vaccine but couldn’t bcuz my blood screening turn out positve for hepetitis B again. I was confused and am still confused! My liver function test came very normal and ok. The virus is still not replating..but the question is..I was vacinated, so why am I HsAg positive?

        1. Hello: There is no cure for hepatitis B, and immunization does not get rid of the infection.
          You may have inactive hepatitis B, and in the past your hepatitis B surface antigen (HBsAg) may have fallen below detectable levels, but it did not go away. It is not uncommon for HBsAg to increase over time and to reach the “detectable” stage. Please keep getting monitored at least once a year to make sure your infection remains inactive and your liver healthy. And remember, avoid alcohol and cigarettes and eat healthy food. Good luck.

  47. While the article looks very optimistic, it doesn’t give any time estimates of when a cure will reach the markets and will be widely accessible.
    Also it is interesting to know what possible side effects such a drug may have, and are they believed to be less severe than the side effects of the modern hepatitis C cure.
    I’m also interested to know if the new cure will potentially rely on the recently discovered CRISPR technology to cut out the cccDNA.

    1. Hello: Our president, Dr. Timothy Block, predicts a cure will be developed in the next three to five years. Researchers around the world are working on a variety of approaches and strategies to eradicate hepatitis, including the CRISPR technology you mentioned. None of us know for sure when they will reach the public. Like you, we await a cure anxiously. Good luck.

  48. Hello doc.
    I come to know in may of this year that i m chronic hepatitis B carrier when i got call from blood bank where i donated .
    Hbs Ag positive

    Hepatitis B viral (HBV) quantitative ~ target not detective

    Hepatitis Be antigen (HBeAg) serum ~ 0.30

    Fibro scan ~ 6.3 kPa

    My question is that i did donate blood several times in 2013,2014,2015 but at that time i never got call from blood bank . But in 2016 i got call that i m infected . I want to know that is it possible that i got infection in 2016 from somewhere . Or In family my mother is hepatitis b non reactive carrier . I got from mom?
    Any thing to worry about report kindly let me know i shall be very thank ful to you . (Specially try to understand how did get infection from mother or somewhere else)

    1. Hello: About 90 percent of babies born to mothers infected with hepatitis B become infected, unless they are vaccinated within 12 hours of birth. It may be that you were infected at birth.
      I don’t know why the blood bank would call you now, and not earlier.
      To find out for sure, if you have a chronic infection (and were infected at birth) or were recently infected, you should get tested for hepatitis B in six months.
      Most healthy adults who are acutely infected are able to get rid of the virus on their own within six months. However, if you continue to test positive for HBsAg after six months, it is considered a chronic infection. Knowing whether your hepatitis B is acute or chronic will help you and your doctor determine your next steps. If you are unsure of what your blood test results mean, please visit: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
      Keep in mind that not everyone with hepatitis B require treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment when you are next tested. Good luck.

    1. Hello: I’m sorry I cannot answer this. We are in the U.S., where doctors do not even test HBsAg levels. Instead, they focus on liver enzymes (ALT/SGPT) and viral load (HBV DNA) to determine how active a hepatitis B infection is. Good luck.

  49. Hello its good news I thank u all of u particularly researchers keep it .I had chronic hepatitis B vurus since childhood and I’m now 29 years old and symptoms started observed 7 years ago like right lower upper abdominal pain when there is stress and too much work and I do regular body workouts
    Reply

    1. Hello: Usually, hepatitis B is a “silent” infection that does not cause physical pain. Please talk to your doctor about your symptoms, and make sure your hepatitis B and liver (ALT/SGPT tests) are monitored regularly. Good luck.

  50. HELLO,Thank you for the good infomation am 34yrs,i came to know that i have hepatis b 2014 after a test but now i have a serious pain i can say in the right side of the chest and my Dr said after doing the scan he said my live its ok i dont need medication what can i do i have a lot of pain thank you

    1. Hello: There is a reason that hepatitis B is called the “silent” infection because it rarely causes any physical symptoms. There are very few sensory nerves around out liver, it’s why two-thirds of people with chronic hepatitis B don’t know they’re infected. I recommend you consult with your doctor if the pain persists, it might be caused by another medical condition. (Read more at: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/)
      Keep in mind that not everyone with hepatitis B require treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged. Healthy ALT levels for men are up to 30, and for women they are up to 19. It sounds like your doctor is monitoring you for liver damage regularly.
      Meanwhile, enjoy a healthy diet, get monitored regularly for liver damage, avoid alcohol and cigarettes, practice safe sex, and make sure your family is tested and vaccinated if needed. Good luck.

  51. can you please tell me how many days you need to find the cure? because it is very assential to me. and also Thank you for your effort.

    1. Hello: Our experts predict a cure will be developed in the next three to five years. Researchers around the world are working on various approaches to eradicate hepatitis B. We are hopeful, it is essential to us and our families too. Good luck.

          1. Hello doc, please my result is as follow
            HB:12.6g/dl
            Wbc:6400
            Pcv:38%
            Ast:19 ull
            ALT:22ull
            phosphatase: 22ull
            Total bilirubin: 0.6
            Conj. bilirubin :0.3
            Total protein: 7.0
            Alb: 5.0
            AFP:> 20.0ng/ml
            ALPHA FETO PROTEIN RESULT:4.2ng/ml
            ultrasound scan :Normal
            HBV DNA:26
            …. please what does my results mean and do I need to be on medication or go for treatment??

          2. Hello: Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Your ALT level is 22, well within healthy levels and your liver ultrasound was normal. Also, your viral load (HBV DNA) is quite low at 26 IU/mL. You appear to be healthy and have “inactive” hepatitis B.
            Please continue to be monitored regularly, avoid alcohol and cigarettes, and make sure your family is tested and vaccinated against hepatitis B.
            Good luck.

  52. Hello,when I have upper back and sholder pain does it mean i have a liver damage or it will go away and leave a health life .

    1. Hello: Back and shoulder pain are not usually associated with hepatitis B. Please talk to your doctor to see if there is another medical condition causing your discomfort. Good luck.

  53. Hello.
    I have a question. I have been diagnosed with hepatitis B. Hbsag is positive and My viral load is negative. For some reasons I had the first shot of hepatitis b vaccine after I was infected. Does it cause any damage to the body? Later I was told that it may activate the virus. What is your opinion on this matter. Thank you very much.

    1. No, the vaccine will not hurt you, though there is no benefit of the vaccine for those already living with HBV or having recovered from the virus.

  54. Hello. I am infected with hepatitis b. My hbsag is positive but my viral load is negative. For some reason I had the first shot of hepatitis b vaccine after I was infected with hepatitis b. Later I was told that the vaccine causes damage and may activate the virus. Can you please give me your opinion. All the best.

    1. No worries! The HBV vaccine does not help those living with HBV, but it will not hurt you. Right now it sounds like you’re in an inactive phase of the virus, which is a good place to be. Continue with regular monitoring with your doctor.

  55. I was told to have super high viral load, but ALT remains normal.

    Doing blood tests every 6 months and ultrasound once a year.

    I’m 25 this year. Should the high viral load be of concern? First diagnosed with Hep B at 20.

    Is there a slim chance that the body will clear it on its own?

    1. You are doing all of the right things! Sounds like you are in the immune tolerant phase, with your high viral load and your normal ALT levels. This is fine. Keep in mind that you are more infectious with a high viral load so be sure you take simple precautions and make sure sexual partners are vaccinated or that you are having protected sex. Continue with regular monitoring of your HBV and the health liver by a doctor with experience with hepatitis B. There is a very slim chance you will clear the virus, but it is very low – between 1 and 3%. There’s always hope!

  56. Hi . I am doctor, 23 yo M and I am HepB carrier. I want to ask can i work in the USA as a doctor. I am planning to take USMLE Exam and want to study further in USA. I am worried… can you help me out ….. thanks in advance

    1. Yes, HBV is covered under the Americans with Disabilities Act. If you come to the U.S. you’ll be able to go to medical school and practice medicine in the U.S.

  57. Hi, I\recently found out I have the HBV virus. I am getting treatment at the Mount Sinai Hospital in NYC. How soon will a cure come out?

  58. Please can the immune system fight chronic hepatitis b ? And if it is so then will it cause you after recovery to take hepatitis b vaccination? Thank you

    1. Most healthy adults (> 90%) newly infected with hepatitis B will clear the virus on their own. Their own immune system takes care of it. Unfortunately that is not the case with babies and young children infected with HBV or a small percentage of people newly infected as adults. For whatever reason the immune system does not initially recognize the virus and not able to overcome it. There are a very small percentage of people living with chronic HBV that will spontaneously seroconvert and lose HBsAg, gain HBsAb and have an undetectable viral load (about 1-3%). If this were to happen, there would be no need to be vaccinated since there would be natural antibodies (HBsAb)

  59. Hi Thanks for your response and your great work
    I am 26 and was diagnosed with hepatitis b in last November.I am HBsAg+ ,HBeAg+ ALT 55 and viral load 400 million.My doctor said ALT up to 45 is considered normal .Since my liver enzyme remained stable for 1 year and it was just above normal limit, no medical treatment apart Peginterferon alfa-2a is recommended .
    I am aware of that ALT above 30 means abnormal liver function and worry about viral load.Do you think it was a good decision and I should agree or insist on other medical treatment or combination of vaccine and tenofovir.

    1. Hi
      My son is 26 and diagnosed with Hepatitis B last Nov.
      He has done liver biopsy ,minimal inflammation,ALT 53 ,Hbsag+Hbeag+ and viral load 400 millions.He had exchange blood transfusion when he was 2 days old.
      He is monitoring every 3 months by one of the b Hepatitis centre which dose many clinical trails,He has been told he is stable?and he can wait until 1-2 months until a new trail will start.Do you think he should start treatment immediately or he can wait.Thanks

      1. Hello: Generally, medical guidelines recommend treatment only if someone is experiencing liver damage. It appears your son’s ALT levels are mildly elevated, however he is in the immune-tolerant stage, which means he has a high viral load (HBV DNA) but the infection does not appear to be causing much liver damage at this time. Generally, antiviral treatment during the immune-tolerant stage has not been highly successful in lowering viral load, so immediate treatment may not be required. Keep consulting with his doctor, who is monitoring him in adherence to current medical guidelines. Good luck.

  60. Hi Thanks for your response and your great work
    I am 26 and was diagnosed with hepatitis b in last November.I am HBsAg+ ,HBeAg+ ALT 55 and viral load 400 million.My doctor said ALT up to 45 is considered normal .Since my liver enzyme remained stable for 1 year and it was just above normal limit, no medical treatment apart Peginterferon alfa-2a is recommended .
    Do you think it was a good decision ?

  61. Hi, i am 31 years old and i was diagnosed 5 years ago with hepatitis b. i am HBsAg+,HBsAb-,HBeAg-,HBeAb+,and HBcAb+. since after the diagnose the doctor assured me that i am at an early phase of clinical clearance of the virus. five months ago after 4 years i consulted another doctor who said the same thing 1 month ago another doctor refused this conclusion by the other doctors(clinical clearance) and asked me to go for treatment, i need your advise. what should i do? and what do you think?

    1. There are other things that factor into whether or not a person is a good candidate for treatment. You want to also look at your ALT (SGPT) and your viral load. Do you know if there is evidence of liver damage seen with an ultrasound, blood work or biopsy? Do you have a family history of liver cancer? I don’t know where you live, but I encourage you to check out our website to learn more about treatment and to take a look at the appropriate guidelines. You can discuss these with your doctor to see where you fit in. Treatment for HBV is a commitment because the medicine must be taken daily and you may need to be on it for years. I understand why you are looking into it further. That said, if you need treatment, then you should get it. http://www.hepb.org , http://www.hepb.org/treatment-and-management/treatment/, http://www.hepb.org/treatment-and-management/treatment/clinical-guidelines/

  62. I am infected of hepatitis b last 6 year . when I had come to know but now I m having some problems in abdomen.. Many of times pain happens in middle chest Nd gas problem had been also started Nd livers side no pain. But other side pain happens like anyone gave prick me a needle… Nd some stir in abdomen last few months. Now I got fever several times it happens itself Nd I took medicine after that I become normal but after 2 or 3 days fever comes again this is repeating 3 times till now.I think constipation is also. But dis time ultrasound report shows me that your liver fatty Nd enlarge.. Rest of things is normal.. Now i have quit my alcohol habbit . but when I drink no pain happens in my liver Nd abdomen… What should I do?

    1. Your situation is a bit more complicated since you have both HBV and fatty liver disease. It is important that you follow the advise of your doctor. First be sure you are seen regularly by a doctor with experience treating HBV. He will also be able to help you with your fatty liver as well. Much of fatty liver disease can often be reversed with lifestyle changes. Continue to NOT drink alcohol. Do not smoke. Change the way you eat and focus on vegetables, fruits, whole grains and fish, and lean meats. Avoid fast foods and processed foods. Cut back on sodas and sweets since too much sugar is not good for a fatty liver. Cut back on saturated fats – greasy food, fried foods, fatty meats etc. Focus on lean meats, monosaturated fats such as avocados etc. This will help your liver and overall health. Ask your doctor if you are a good candidate for treatment for your HBV, but you may end up starting with some of these changes to see if you feel better and your blood work looks better. Please see your doctor to learn more.

  63. In how many years can we expect the cure for HepB ? While browsing over the internet, i found that the cure has been discovered by scientists in Australia, with the treatment proving to be 100% successful at eliminating the virus. Researchers used a combination of antiviral and anti-cancer drugs to destroy the hepatitis B virus (HBV).
    But there is no such confirmation here. Is the cure really discovered? Please please reply me. My girlfriend is in a lot of depression and i cannot see her like that. Seems like she got it by birth. How much time is it going to take from now? any visible progress you got? Any tentative time you can give us? years roughly would be fine atleast.

    1. Hello: Many researchers around the world are working to find a cure, however there is no cure yet. Scientists in Australia and elsewhere are working on treatments that are in the early phases of clinical trials, either being tested on lab animals or in early human clinical trial phase. For an overview of new hepatitis B drugs now in clinical trial, please see: http://www.hepb.org/treatment-and-management/drug-watch/
      For a list of clinical trials involving a variety of treatments that are currently recruiting hepatitis B patients, please see: http://www.hepb.org/treatment-and-management/clinical-trials/
      Experts now predict that a cure should be developed in the next five years, we are very optimistic.
      To read about the challenges researchers currently face, please see: http://www.hepb.org/blog/global-researchers-brainstorm-solutions-search-cure-hepatitis-b/
      Tell your girlfriend not to give up hope!

  64. Hi dr

    Me and my gf are deciding to have babe

    About last year I find out I have hep b and thanks god my gf had all her hep a and b vaccine so she is safe if we gonna have babe I know babe need get vaccine in less than 12 hours so babe will be safe??
    Also is my gf be safe to because she already had hep b vaccine so she won’t get it from me ??

    Thank u

    1. Hello: Good questions, you are a good partner and will be a good father. As long as your girlfriend was vaccinated, she should be protected. However, to be sure, she should get tested for the hepatitis B surface antibody (anti-HBs or HBsAb). As long as she has at least 10 mIU/mL of HBsAb, she is completely protected against hepatitis B infection. Good luck.

  65. I have HPV n now after eating I do have discomfort in my abdomen with the left side getting protruding out but when am hungry my abdomen is normal and no severe discomfort, only rumblings and some movements in my middle and lower abdomen. I have dry eyes, stance body odor, dark yellow urine and pain in my right side of the rib cage. is it a sign of cirrhosis with my ALT at 21 and AST 25.

    1. Hello: I encourage you to see y our doctor to find out what is causing your symptoms. It is impossible to say if it is a result of your hepatitis B infection. Your liver enzyme ALT level shows no liver damage, but it’s important to discuss the symptoms with your doctor. Also, have you have an ultrasound lately? This another important too to evaluate your liver health. And of course, avoid alcohol and cigarettes, and eat healthy foods. Good luck.

  66. Hi, I have checked my Hepatitis B status and it shows that Iam positive. However my parents and other family members were all negative for this virus.
    With that I knew that I must have got this virus from my ex girlfriend whom I used to date.
    After 6 months my result still reveals that Iam positive.
    Is there any possibility that my immune system can clear off this virus since I believe I got this virus at an adult age of around 22 years old.
    Awaiting your reply. Thanks

    1. Hello: Sometimes it is impossible to say how you were infected. Most people with chronic infections were infected with the hepatitis B virus at birth or during childhood. Perhaps you were given a shot or had a medical procedure with a device that had not been properly sterilized. It is difficult to say. What is important is that you continue to be monitored for hepatitis B to see if your immune system will clear the infection.
      Keep in mind that not everyone with hepatitis B require treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment.
      If you ever do, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir. Good luck.

      1. Thank You very much for the reply, I will keep check on this site for more information regarding the progress on finding cure of this virus.

  67. Hello sir i am 30 year old and i was my blood test in before 12 year and report is hepatitis b positive and now now over sgot 47 and sgpt 53 and pain in right side lower ribs . Now any treatment for this

    1. Hello: Hello: Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. However, every lab is different so an SGPT level of 53 might be just slightly above normal.
      Hepatitis B rarely causes abdominal pain. Please talk to your doctor to see if this discomfort is caused by another medical condition. For more information on hep B and abdominal pain, please see: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/
      Good luck.

    1. Hello: Experts predict in about five years, a cure should be developed.
      There is no cure yet for hepatitis B, however there are two very effective antivirals -– entecavir and tenofovir (Viread) and its TAF formulation that was recently approved by FDA –- that quickly reduce your viral load (HBV DNA) and your risk of liver damage. To find out the latest in new hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
      And, for an update from a recent international workshop on future hepatitis B cures, please visit: http://www.hepb.org/blog/global-researchers-brainstorm-solutions-search-cure-hepatitis-b/
      Good luck.

  68. Hello I when can we expect the cure for hepatitis b I was diagnosed with the virus 2 years ago still wait for the cure my virus is low my doctor told that I don’t need treatment thanks

    1. Hello: Remember, most people with hepatitis B will live long and healthy lives and never require treatment. There is no cure yet for hepatitis B, however there are two very effective antivirals -– entecavir and tenofovir (Viread) and its TAF formulation that was recently approved by FDA –- that quickly reduce your viral load (HBV DNA) and your risk of liver damage. To find out the latest in new hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
      And, for an update from a recent international workshop on future hepatitis B cures, please visit: http://www.hepb.org/blog/global-researchers-brainstorm-solutions-search-cure-hepatitis-b/
      Good luck.

  69. Hello sir,I am 31 yta of age. I was tested hep.b.negative in 2007 when I when I was entering intothw nursing ,a yr later I went to donate for a sick child and my results was positive.I went to repeat the test on two occation and the Dr said I dont need treatment. But about a week now am experiencing some chest pain.what should I do?? Unfortunately about ywo yrs now I have not gone in for the test so I can’t remember de test figures.

    1. Hello: Hepatitis B rarely causes symptoms, and chest pains are not commonly associated with hepatitis B. Please see your doctor about this, as it may result from another medical condition that requires attention. Good luck.

  70. Hello sir,thanks once again for your resposes.but this is my confusion, I went into testing and vaccination of hep.b.I got to school where I tested a lady of 19yrs negative and the vaccination was administered after which she went into hostel and brought a Hosp.report that show positive and she put on tab heptivir for 30days. I was a bit confused.so I waited for another month and repeated the test and it was negative again and I gave the second dose of the vaccine. My question is,was the first test right ?? And if it is right why was the second and third test show negative.? Or the medication has distroyed the virus?meanwhile the medications was taken two weeks when my test was carried out.,

    1. Hello: It is hard to know, and I am not sure I understand the scenario. An immunization does not cure an infection. Perhaps she was recently infected and was experienced an acute or short-term hepatitis B infection. When healthy adults are infected, it can take up to six months for their immune systems to clear the virus. Perhaps she was tested near the time that she was clearing the virus. The good news is she was not infected. Good luck.

  71. Hello doc. i am Hbsag reactive and i would like to know from you since you are an expert regarding this disease. what are the things that i need to avoid such food and any other things that would worsen my disease and what will happen to me if i get vaccinated but im still reactive. Please enlighten me

    1. Hello: Unfortunately, getting vaccinated will not make your infection go away. The hepatitis B vaccine only contains the hepatitis B surface antigen (HBsAg) protein from the virus, and you already have this in your body.
      The best thing you can do for yourself is to eat healthy, low-fat foods, and avoid alcohol and cigarettes, which harm your liver. Good luck.

  72. Hello, I am 30 years old from West Africa, I was dignosed with the virus 3 years ago and am still positive my recent result show:
    *ALT= 18.5 (Normal range 0-49 U/L)
    *AST= 29.4 (Normal range 0-46 U/L)
    *Anti HBeAg-Antibodies to hep b envelope Antigen= Reactive 0.003 (Non-reactive:>1.0,Reactive:<=1.0)method CMIA
    *HBeAg-hep b envelope antigen=Non Reacive 0.099 (Non-reactive:=1.0)method CMIA
    *HBsAg Quantification >13000 IU/ml above measuring range
    *HBV DNA=18,683 IU/mL (range 20-170000000iu/mL,conversion factor 1 IU/ml -5.82 copies/ml,method Real Time PCR)

    please I want to know if I need to start treatment, if yes which is more effective? injection or tablets?

    1. Hello: Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT. Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30. Your ALT i9s 18.5, which is well within the healthy range. However, you still have a moderate viral load (HBV DNA) so you need to have your ALT and viral load monitored regularly to make sure the infection does not harm your liver.
      As you probably know, avoiding alcohol and cigarettes is important to maintain your liver health, as well as eating a healthy diet.
      Continue your good work, practice safe sex and make sure your family members are tested and vaccinated.
      Many people with hepatitis B never require treatment and live long and healthy lives, however it your doctor ever does recommend treatment (see WHO HBV treatment guidelines at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/), the top two antivirals currently recommended are tenofovir and entecavir. Good luck.

  73. Hello: my girl friend HBV PCR is 1250 and her fibroscan is 10.3 (f3).
    HBe Ag is Negative
    HBs Ab is 23 and she eat tenofovir once a day.
    Is it dangerous?We can get married or not good?

    1. Hello: First of all, you can absolutely get married. Have you been tested for hepatitis B and vaccinated? That is an important first step in order to safeguard yourself from infection.
      From what you indicated, I assume she is undergoing treatment and takes a tenofovir pill daily. This is a very effective antiviral that reduces viral load and her risk of liver damage.
      It is important that she is monitored regularly, and also has her liver enzymes (ALT/SGPT) tested regularly to monitor for liver damage.
      If and when you decide to have children, it is very important that the baby is immediately vaccinated with the hepatitis B vaccine within 12 hours of birth, and also is given HBIG (hepatitis B antibodies) to avoid infection.
      Good luck.

  74. Hello!

    I am 25 yrs old. And diagnosed since 2011 with hep b until now. But i just want to ask can hep b carrier not allowed to work abroad due to this disease. Those any legal regarding on this. I am filipino working as skill mechanic. Any advice. Thank you

    1. Hello: Great question, there are some countries in the Middle East that will not issue work visas to people with hepatitis B. This is unfortunate and discriminatory as people with hepatitis B pose no infection risk to others professionally. Most European and North American countries do no restrict immigration or visas based on hepatitis B status. Good luck!

  75. Hello! Thanks for creating hope in us. Please comment about “birinapant” drug that was undergoing clinical trial and was found to clear the hbv in mice. Is it effective cure all the same? Thanks

  76. I have been tested positive hpb n my doctor told me not to start medication ,up to what viral load shall I start medication

    1. Hello: Keep in mind that not everyone with hepatitis B require treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. If you ever do, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir. Good luck.

  77. Sirs, I have a simple logical question.

    The pharmaceutical companies make and sell these drugs. As such they make billions of dollars a year, simply by treating patients with their drugs. Why would they want a cure developed? This would result in loosing all those billions of their income. It could be that all the new drugs in the pipeline also aims to just control the virus, and not cure it.

    1. Hello: There are millions of people infected with hepatitis B who would purchase a drug that could cure them. That is a large market for any drug developer and would produce more profit than current antiviral treatment. Good luck.

      1. I just want to supplement Serji’s statement. I also feel that in the long term for drug developer company a continues treatment with current available will be benefiting more than developing a cure which they could sell out for short period. So, don’t they have any reservation of bringing a cure in market. Or is there someone who is taking care of it.
        Thankyou

        1. Hello: Everyone wants a “complete” cure — not just a temporary fix that antivirals provide. There are many companies working on a cure and we remain hopeful. Good luck.

  78. I tested and found that i had hep b i straight away did LFT it was normal, HBSAg Negative, Viral load 12000 that was by 17 September 2016 i have not taken any treatment please advise am i safe

    1. Hello: In case it was written incorrectly, do you mean you are HBsAg-negative? Perhaps the lab report said you were HBsAb-negative (which stands for hepatitis B surface antibodies), which makes sense if you have a detectable viral load (HBV DNA).
      Keep in mind that not everyone with hepatitis B require treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. According to your report, you have normal liver function test results, and therefore do not require treatment at this time. Please consult with your doctor and get tested regularly. Good luck.

  79. HiI just want to ask you a person who is Hbsag is positive for almost 2o years but is inactive and he don’t know how it was affected does this mean he has only property doctors said this ur body defend it and will desapear what does this mean

    1. Hello: Anyone who has hepatitis B for 20 years has a chronic infection. As long as someone tests positive for the hepatitis B surface antigen (HBsAg), they can spread the infection through unsafe sex. While there is no cure for hepatitis B, over time in a small percentage of cases people do clear the infection, though this is rare. It is important to continue to get monitored for hepatitis B, and get your liver enzymes (ALT/SGPT) tested at least once a year to make sure the infection is not harming your liver. Good luck.

    1. Hello: Kissing does not spread hepatitis B, only direct contact with infectious blood and body fluids (such as semen during unsafe sex) spreads the infection. The best protection against hepatitis B is safe and effective vaccination. Good luck.

      1. What about saliva if the person kissing the other one may be saliva can reach the mouth of the other one so I’d that person has no any virus and inactive what about this condition

        1. Helo
          I tested positive for hep b about 4 years ago.I lost my 1st and 2nd boyfriends because of the disease, now am in a new relationship and am scared to let him know because he might also leave.I don’t want to end up lonely. Please advise me. Thank you

        2. Hello: If one of you is infected with hepatitis B, kissing does not spread the infection unless the infected person has a cut or open sore in their mouth that discharges infectious blood or body fluids. Good luck.

    1. Hello: The hepatitis B vaccine is very safe and effective. However, we recommend that before you have unsafe sex with someone, they should get tested for the hepatitis B surface antibody (the antibody that prevents infection following immunization) to make sure they have enough antibodies to be protected (at least 10 mIU/mL). Also, that person may not remember correctly if they got the vaccine, or the full three doses. And it’s important to disclose, considering trust is vital to relationships. or more information, please read: http://www.hepb.org/blog/romance-in-the-air-take-a-deep-breath-and-disclose/ Good luck.

    1. Hello: Excellent question, especially with more states in the U.S. approving medical and recreational marijuana. Research into whether or not marijuana damages the liver is conflicting. We know that smoking cigarettes damages the liver (causes increased fibrosis), so it is possible that smoking marijuana would also cause damage. Ingesting marijuana in a different way may be safer – cooking with it, for example. However, some of the chemicals in marijuana (called cannabinoids) may trigger changes to liver cells and lead to more liver damage (fibrosis) regardless of how it is ingested. Bottom line: There is no adequate evidence. If you must use marijuana the evidence suggests consuming it in a way that does not involve smoking it.

    1. Hello: Kissing does not transmit hepatitis B unless you have an open sore or blood in your saliva. As always, the best protection for your partner is immunization. Good luck.

  80. Hi I am a mom of 11 yr old boy. I was also diagnosed with Hep B nine yrs. ago. It was devastating and the what hurts me more when I found out that my son also have it. I am taking enticaver for 8 yrs. and i feel normal my blood work is undetectable. My doctor wants to start my son with medication within two weeks and I am afraid how his body will react. I really hope that we can have the cure very soon. Thank you for trying your best to fibnd the cure…My prayer!

    1. Hello: I’m sorry to hear about your and your son. Is your son’s doctor a hepatitis B expert? And, is your son experiencing liver damage, indicated by an ultrasound and/or elevated ALT (SGPT) levels? Medical guidelines do not recommend treatment unless there are signs of liver damage. We too hope a cure will be found soon! Good luck to you and your son.

  81. Hello I’m diagnosed with hepatitis b since February 2016 and my doctor says that the virus are very little in genius what is that?and i’v fiver and knees pain but my liver is very well could you please give me some info

    1. Hello: I’m not sure I understand the question, but your doctor may be saying that your immune system is working to stop the virus from multiplying and you have a low viral load, or a small amount of virus in your body. I am happy to hear your liver is healthy. Please see your doctor about your other symptoms, as they may be caused by another medical condition. Good luck.

    1. Hello: There is a reason why hepatitis B is called the silent disease, because it rarely causes any symptoms because there are very few sensory nerves around the liver. The pain you describe is not usually associated with hepatitis B, we recommend you see your doctor and describe your symptoms to see if it is caused by another medical issue. For more information about hepatitis B symptoms, please see: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/
      Good luck.

      1. My is Mia I have been tested positive hep b, one and a half month ago and it was acute. I’m currently taking livolin Forte. And I’m currently experiencing all the symptoms. Please is their a chance that I can fight off this infection in the next few months? Thank you

        1. Hello: When healthy adults are infected with hepatitis b, nearly all of them are able to clear the infection after six months. Please get tested again in six months to see if your immune system was able to clear the infection.
          Keep in mind that most herbal remedies have NOT been found to help cure hepatitis B. The best thing to do is eat healthy foods and avoid alcohol and cigarettes. Good luck.

  82. I have a friend with hepatitis b and she just noticed it yesterday and she’s 23 weeks pregnant hope the baby is safe and am sure the husband will have it too what can they do they have been treating infection even before the wife got pregnant treated with argumenting what can be the cause of this virus again

    1. Hello: It is very important that your friend who is pregnant makes sure her newborn is vaccinated with the first dose of the hepatitis B vaccine within 12 hours of birth, or else the baby will be at high risk of becoming infected. The newborn should also be given a dose of HBIG (hepatitis B antibodies) to prevent infection. The husband should be tested also, and the wife should be monitored at least annually if not more often to make sure the hepatitis B infection does not harm her liver.
      While there is no cure, there are very effective treatments available to lower viral load and the risk of liver damage.
      Many people with hepatitis B live long and healthy lives, especially if they avoid alcohol and cigarettes. Good luck.

    1. Hello: Hepatitis B is spread by direct contact with infectious blood and body fluids. It is spread the same way syphilis is, but syphilis does not cause hepatitis B. When you test positive for the hepatitis B surface antigen (HBsAG), it means you are currently infected with hepatitis B. When someone is first infected with hepatitis B, it is considered an acute infection. Most healthy adults who are acutely infected are able to get rid of the virus on their own within six months. However, if you continue to test positive for HBsAg after 6 months, it is considered a chronic infection. Knowing whether your hepatitis B is acute or chronic will help you and your doctor determine your next steps. If you are unsure of what your blood test results mean, please visit: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
      Once you determine if you have chronic hepatitis B, your doctor may run additional additional tests to see what stage your hepatitis B infection is, and whether it is harming your liver. Keep in mind that many people live long and healthy lives with hepatitis B, especially if they avoid alcohol and cigarettes and eat healthy foods. While you are infected, be sure to practice safe sex so you do not spread hepatitis B, and to protect yourself from other sexually-transmitted infections. Good luck.

  83. What does ” multiple echogenic foci measuring up to 0.6cm” mean? It came from the ultrasound of the abdomen report.

  84. Seems things are changing… Our hope to get cure of HBSAG is not reality according to latest updates… Because some of the company has stop development of drugs like ARC 520..now recent updates says.. Can’t change anything before 2018. So your effort,money and heard work is in vain, we where excerted that the cure is within reach… But in reality it’s beyond reach….

  85. According to the arrowhead the cure will be in market by 2018…but it’s has to start all over again from the beginning …

    Sometime it’s funny… When hepatitis foundation updates all spurt of positive about hepatitis…we r really in need of cure…

      1. Hello: There is no cure yet for hepatitis B, however there are two very effective antivirals -– entecavir and tenofovir (Viread) and its TAF formulation that was recently approved by FDA –- that quickly reduce your viral load (HBV DNA) and your risk of liver damage. To find out the latest in new hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
        And, for an update from a recent international workshop on future hepatitis B cures, please visit: http://www.hepb.org/blog/global-researchers-brainstorm-solutions-search-cure-hepatitis-b/
        Good luck.

  86. Im recently diagnosed with hepa b. I was working abroad. I was in vacation last June 2016 in my home country and come back abroad July 2016 and in late October 2016 i had signs and symptoms i went to the hospital and got these HCV negative, HBV positive result bilirubin 75.8 ALT 1696 AST 1215 QQT 94.
    Had also second test last November 12 2016 here are the result HBsAG reactive anti HBC total (CMIA) 7.22 reactive Anti HBs 0.08 nonreactive ALT 448 AST 119 alkaline phosphatase 135.0 my doctor said i need to recheck it by January 2017

    Is it acute or chronic? Any advice for my status.

    My last hepa b test was December 2015 and i was negative back then.

    Thank you very much

    1. Hello: If you tested negative for HBsAg last December, and now test positive for it, you are probably experiencing an acute or short-term infection. It can take around six months for an adult immune system to clear the infection. Your liver enzymes are quite high, indicating some liver damage. It is important to continue to be monitored and also to avoid alcohol and cigarettes, and eat a healthy food. Also, practice safe sex so you do not spread the infection. Good luck.

  87. Hello my result for hepatitis b as follows
    Hepatitis b core Igm negative

    Pcr hep b quant. 320 cps/ml,55 Iu/ml,2.51 log

    1. Hello: It is hard to assess your condition from the information you provided. Have your tested positive for the hepatitis B surface antigen (HBsAg)? Also, if you are HBsAg-positive, have you had an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. Good luck.

  88. Hello Sir Good Day,I am very much thankful that sooner there is cure for hepatitis B..In fact it shows that the result of my AST GOT was too high it reached 225 u/l and my ALT GPT reached up to 337 and ALP 468 and GTP 90 U/L.I HOPE THAT THIS ILLNESS CAN HAVE HAVE TREATMENT SOMEDAY…IT ALMOST 10 YEARS WHEN I FOUND OUT THAT I HAVE THIS KIND OF DESEASE..

    1. Hello: Your liver enzyme tests are very high, please see a doctor and ask about treatment. Currently, medical guidelines recommend antiviral treatment with either entecavir or tenofovir (Viread). These are pills taken daily that are effective in reducing viral load (HBV DNA) and your risk of liver damage. Good luck.

  89. Hello
    Now there treatment for hepatitis c and cirrhosis caused by hepatitis c also treated.
    Is it possible to discover a cure for hepatitis b , cirrhosis resulting from it treated?

    1. Hello: Experts are optimistic that a cure will be developed, as it was for hepatitis C. Unfortunately, hepatitis B is a more complex virus than hepatitis C, but there are many biotech and pharmaceutical companies working on a cure, so we remain optimistic. Good luck.

    1. Hello: Unfortunately, Arrowhead’s ARC 520 and 521 products have been removed from clinical trials. The drugs were used a much higher dose than were being used in human clinical trials in lab animals, which resulted in some animal deaths. As a result, FDA required Arrowhead to immediately stop the clinical trials. Arrowhead is continuing research on other hepatitis B drugs.

        1. Hello: No, I believe Arrowhead is no longer working on those drugs, even at a lower dose. However, they are working on other treatments. Thank you.

    1. Hello: When we are infected with the hepatitis B virus, we test positive for the hepatitis B surface antigen. As our immune system starts to fight the infection, it produce antibodies to get rid of these hepatitis B antigens. Over time, we clear the hepatitis B “e” antigen (HBeAg) and develop “e” antibodies (HBeAb). It’s a good sign to test positive for the hepatitis B “e” antibody, it generally means your viral load (HBV DNA) is low.
      Is this the first time you have been tested for hepatitis B? To know if you were recently infected and have a short-term “acute” infection, you need to be tested again in six months.
      When healthy adults are infected, it takes about six months for their immune systems to get rid of the infection. When newborns or children are infected, their immature immune systems don’t recognize and fight the infection and it can become chronic and last for many years.
      Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage, which you are not, based on your report. Keep getting monitored regularly, and avoid alcohol and cigarettes. Good luck.

        1. Hello: Usually, the immune system is not able to clear hepatitis B easily, and the infection (indicated by HBsAg) can persist for years. However, keep in mind that many people with hepatitis B live long and healthy lives. It is important to eat healthy foods, and avoid alcohol and cigarettes. Good luck.

  90. Hello,
    Please I would really love to find out the following:
    -Can HBV Br transmitted through sweet, or body fluid
    -Can an acute HBV patient use Tenofovir, is it harmful if he does or it has no effect.
    -Can you help interprete this result
    HBsAg (Hepatitis B Surface Antigen Screening)= 0.16 (POSITIVE)

    Anti HBsAg / HBsAb -Total antibodies to Hepatitis B Surface Antigen (Quantitative)= 1.50 (Negative)

    Anti HBcAg – Total antibodies to Hepatitis B Core Ag=0.00(Positive)

    Anti HBcAg – IgM antibodies to Hepatitis B Core Ag=0.31(Negative)

    HBeAg – Hepatitis B Envelope Antigen=0.00(Negative)

    Anti HBeAg – Antibodies to Hepatitis B Envelope Antigen=0.20(Positive)******

    My HBV DNA is presently at 698 IU/Ml and my AST 28 U/l ALT 23 U/L

    -I started to treat with Tenofovir, two months so far(I’m not financially boyant to treat with more expensive drugs).

    -I fell really weak most times and I have joint pains, Can I quite or my HBV DNA would flare up if I do
    -Do immunace, selenium have any advantage against the virus

    Thanks!
    God Bless

    1. Hello: Hepatitis B is not spread through sweat, but it is spread through direct contact with infected blood and body fluids (such as semen).
      Antivirals are usually not used in patients who have a new, acute infection unless there is liver damage.
      As you know, you are infected with hepatitis B, as indicated by your positive hepatitis B surface antigen (HBsAg) result. The good news is your viral load is low and your liver enzyme test (ALT/SGPT) currently shows no liver damage. Were you experiencing liver damage (with high ALT levels) before starting treatment? Your doctor is in the best position, based on his knowledge of your overall physical health, age, gender and family history of liver cancer to know if you need to continue antiviral treatment. Good luck.

      1. No I wasn’t, the plan was to get my DNA to undetectable And try to boost my immune with selenium before stoping, but now I keep reading up writup of the DNA flaring up if I eventually stop and so I would have to use it for life.

  91. I’m 3yrs now since HbsAg ve test, my current exam.. results all are normal except I had swelling in my liver & spleen. but Dr. said it is hemangioma. And he said I should take Texavir for 8 month. Any advice please.
    My God bless you in all what you are doing.

    1. Hello: A hemangioma is a benign tumor. and texavir is a generic tenofovir, which is a very effective antiviral. I recommend you continue to see your doctor regularly, and of course avoid alcohol and cigarettes, and eat healthy foods. Good luck.

  92. i had been diagnosed as Hepatitis B two yr ago. Some time i have abdomen pain(not regular) and i didnt follow up with doctor.
    What sould i do??
    Your kind advice please?

    1. Hello: Hepatitis B is called the silent infection because it rarely causes side effects, such as abdominal pain. Our livers have very few sensory nerves near them, so we rarely feel any physical discomfort from a hepatitis B infection. If you continue to have discomfort, I recommend that you see your doctor. A medical condition unrelated to hepatitis B could be the cause. For more information about abdominal pain and hepatitis B, read: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/
      Good luck.

  93. I m 45 years old,since 12 years i have been diagnosed with chronic hepatitis B ……i have a family history with chronic hepatitis b ….i am e antigene negative in fibroscan i am F2……mOST OF THE TIME THE VIRAL LOAD IS LOW THE TRANSAMINASES ARE NORMALS around 32ui/l…
    i m not in any medication ……Do you have any advice for me please……I m very anxiuos …..

    1. Hello: It sounds like you are doing fine, your liver is healthy (as indicated by your ALT/liver enzyme) and your viral load is low. Continue to eat healthy foods, avoid alcohol and cigarettes, and continue to be monitored regularly. You have no reason to be anxious, many people with hepatitis B live long and healthy lives. Good luck.

    1. Hello: They are both very effective in lowering viral load (HBV DNA). However, during clinical trials TAF was more effective in reducing liver damage (resulting in normal liver enzymes — ALT/SGPT) in more patients than tenofovir. More information about TAF’s effectiveness will be revealed in the months ahead as more people are prescribed it. Good luck.

  94. Hello Hepbtalk,

    How long for the clinical trial phase 1 to start for these new promising drugs AB-423 (Capsid Inhibitor)?

    I am HBsag positive , viral load and ALT generally low but recently viral load has gone up but ALT last time check 3 months ago was normal.

    Currently i experienced bilirubinuria, nausea, can these be due to antibiotics (doxycycline)taken for seperate bacterial infection?

    in other words How would we differentiate if new viral load is high with elevated ALT, whether it was doxycycline or the Hep B?

    Thank you for your time.

    1. Hello: Having another medical issue, such as an infection, can stress the immune system and possibly lead to a rise in viral load (HBV DNA). However, an increase in viral load needs to be great larger (10 or 100-fold) to be medically significant.
      And yes, antibiotics certainly can cause stomach problems. Please talk to your doctor about any new symptoms or medical conditions. Good luck.

      1. Hello,

        Thank you for your response.

        Received my Viral load results today:

        PCR HBV IU/mL_exponent: 2.68 x 10^5

        PCR HBV (DNA copies/mL exponent : 4.55 x 10^5

        ALT 34
        AST 24
        Bilirubin 17.3 mmol/L

        would you consider this as a high viral load to consider therapy/ “treatment”

        As the viral load has been steadily but surely increasing over the years (i am 28 years old) i am a bit concerned about cirrhosis or HCC.

        If therapy were to be started would it be better to give it a go with interferons or go straight to antivirals. (i understand ALT is not high)

        Thank you

        1. Hello: I’m sorry but could you not use log references (10^5) and instead write out the number for your viral load? Then I can answer more accurately.
          Keep in mind that not everyone with hepatitis B requires treatment. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT. Our liver cells release ALT when they are damaged or die. Your ALT levels are in the healthy range at 34, so doctors may not consider you a candidate for treatment. Please continue to be monitored regularly, at least once every six months, so your liver health can be monitored. If your ALT does start to creep up, and your have the insurance cover or access to pegylated interferon, you may want to try it first. Talk to your doctor and also find out what your HBV genotype is, as some genotypes respond better to interferon than others. Good luck.

          1. Hello again,

            Thank you for your reply. I am sorry for the Log in viral load for some reason it was written in that form on test results.

            These are viral loads over the years:

            year 2012: 4079 IU/mL
            Year 2013 4190 IU/mL
            Year 2014: 26348 IU/mL
            Year 2016: 26800 IU/mL

            Year 2008: HBeAg Positive
            Year 2012 until 2016: HBeAg negative
            Year 2012 until 2016: HBeAb positive

            What happend? seroconversion? mutation? if seroconversion why elevated viral load?

            if mutation, ALT within normal range?

            i was reading Literature and AASLD/EASL guidlines suggesting interferons for better effect in HBeAg Positive patients.

            However given I am current surviving more or less on one kidney at the moment, I am therefore not very keen on antivirals.

            finally which genotypes responds better to interferons?

            I am so sorry for many questions in advance, I am just a worried medical student and I hope to graduate before I die to this terrible virus.

            Thank you so much for your help.

          2. Hello: Your viral load (HBV DNA) may be slowly increasing because your immune system may be weakened by your kidney problems. As long as your ALT indicates your liver is healthy, you may not be a candidate for treatment even though your viral load is rising. Please continue to be monitored frequently, and talk to your doctor about treatment options if and when you ever have liver damage.
            The U.S. FDA recently approved a new antiviral, called TAF or Vemlidy, which is a new, lower-dose version of tenofovir. It can lower viral load without negatively affecting kidney function.
            Good luck.

  95. hi Dr.I Dont see Abivax in drug watch, is it approved by FDA or outdated from clinical trial?? and is it a functional cure to???

    1. Hello: There is no cure for hepatitis B, however there are two very effective antiviral medications (pills that you take daily) that are effective at reducing your viral load (HBV DNA – the amount of virus you have in your body). They are entecavir and tenofovir (Viread.) Good luck.

  96. This is a great news for all people infected with this terrible virus. Is this the true, based on really fact that during the period of three – five years will be available a cure or this is just an assumption ?

  97. Thank You for your answer.In 2010 I have going through a very difficult health situation for this I was hospitalize for one month. All the analyzes that I did during that period shows no sign of HBsAg or any other virus that probably was attacking, even why my liver was enlarge and ALT and AST was very high. I was recovered after 2 weeks. I had very high temperature and doctors treated me with antibiotics during that 2 weeks. After I recovered and I had no more temperature, I did analyzes that results: HbsAG positive HbeAB positive, Igm anti Hbc negative, my mother also results positive of HbsAG, does this mean that I was infected since I was born ?? After that I checked my ALT every month for a period of 6 months. Doctor told me that I am a healthy carrier.Now, after 6 years Iam still in fear and my life has’t been the same after that, I lost everything. I am only 23 years old, but I look like 33 because I have suffered a lot my situation and I have problems with sleeping. I pray every night and hope every day for a cure developing asap. I just want to return living and being happy. Thank YOU for your support !

    1. Hello: It is impossible to say when you were infected, but if your mother has chronic hepatitis B then she may have unknowingly infected you when you were born. I don’t know why the test in 2010 did not identify your hepatitis B infection.
      Please do not let your hepatitis B define you, you are much more than an infection. You CAN Date. You CAN marry. You CAN have a normal life.
      It’s not health, income, or outside circumstances that hold us back. It’s our perspective. There are many people who succeed in this world in the presence of severe obstacles. They succeed because they don’t let it limit them. And they don’t feel sorry for themselves – they use what they do have to their advantage.
      Please ‘KNOW’ hepatitis B is not a punishment or a disability. It can be an opportunity to discover how to love and accept yourself. And to learn what really matters in relationships and life.
      Good luck.

    2. Hello: I am sorry to hear about your suffering. Hepatitis B is commonly transmitted from infected mother to newborn, in fact about half of all chronic hepatitis B infections result form mother-to-child infection. If you still test positive for the hepatitis B surface antigen (HBsAg) after several years, it means you are chronically infected. Please do not let hepatitis B ruin your life. First, you are healthy and lucky to have inactive hepatitis B. It is not harming your liver, as long as you eat healthy foods and avoid alcohol and cigarettes, you can have a full, healthy and happy life.
      Do not let your hepatitis B define you, you are so much more than your infection. You can marry, have children and lead a full life. Your partner can be vaccinated and be permanently protected from infection. If you have children, as long as they are vaccinated with the first dose of the hepatitis B vaccine within 12 hours of birth, you do not have to worry about them becoming infected! Please stop suffering. Your mother is healthy, and she too has hepatitis B.
      Do not be limited by your hepatitis B. Good luck.

  98. Hello…we live with hope.
    i have a simple question
    as you said,There have been some setbacks this year, and some of the clinical trials did not go as well as companies hoped….according to this you think how many of years will be added to three-five years for availabal a cure??
    please answer to me this is so important for me and my life.
    thank you very much

    1. Hello: It is very important for millions of people, and I wish I knew the answer. What encourages me is there are many companies now researching a cure for hepatitis B. Failures are inevitable, and with each failure comes more knowledge about what it will take to eradicate this infection. We are still hoping for a cure to be found in the next several years. Good luck.

  99. Hi

    Would it be considered safe to have, say, just 5 ounces of beer a month? Would this small ingestion a month make a significant difference to the liver’s condition? I am on medication. Thank you.

    1. Hello: Five ounces of beer will probably not make a difference, but are you sure once you start drinking beer you can stop? Many of us find it difficult. Bottom line, the less, the better. Good luck.

  100. i have been a carrier since my birth. On Tenofevir since 2008. checks with the doctor every 3 months with blood tests. viral load have been undetectable since I started the medication. The doctor says everything is under control every visit. MY concern: undetectable viral load with medication means I have nothing to worry about as long as I keep taking the medication? Is there continual liver damage done?

    1. Hello: You are correct, doctors believe that a low or undetectable viral load (HBV DNA) means there are fewer virus infected your liver and causing damage. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. Were you experiencing liver damage, and is that why the doctor started treatment?
      Also, do you now test positive for the hepatitis B “e” antigen? What about the hepatitis B surface antigen?
      Because you have been on tenofovir for so long, I hope you talk to your doctor about your overall health and whether you need to continue on antivirals. Also, do you have your kidney function tested regularly?
      This blog explores the topic of long-term antiviral use:http://www.hepb.org/blog/can-people-with-hbeag-negative-hepatitis-b-ever-stop-taking-antivirals/
      Good luck.

  101. I’m hep b patient in Ghana for about 8 years. Can I get some of the drug to treat the virus ? I’m still living normal and healthy without any drug please what causes this ? I need some of ur drugs in Ghana. Thank you

    1. Hello: Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. Also, there is an organization in Ghana working hard to eradicate hepatitis B. Below is its contact information if you would like information, or to join them as a volunteer. Good luck.
      Hepatitis Foundation of Ghana
      Theobald Owusu-Ansah
      Phone: 00233 247093893
      Email: theobald2003@yahoo.com Ghana
      http://theobaldhepb.org

  102. Please i am the infected and my wife too is not infected with the hep b therefore I’m asking you that can my children about to be born get infected with the hep b ? As I told u i am with the disease and my wife is not with it. She has taken all her vaccination. Thank you

    1. Hello: I am happy to learn your wife has been immunized. When your baby is born, within 12 hours of birth make sure he or she is vaccinated with the first dose of the hepatitis B vaccine, that way you can be confident that the baby will never catch hepatitis B from you or anyone else. Then make sure the child is vaccinated with the second shot 30 days later, and the third, final shot five months later. Good luck.

    1. Hello: I am sorry but you would have to provide the specific lab test results in order to accurately interpret the results. Thank you.

  103. Please this was my results from lab.
    TOT BILIRUBIN 19.49 NORMAL
    DIR BILIRUBIN 11.86 umol /L high
    IND BIL 7.6 NORMAL
    TOT PROTEIN 69 NORMAL
    ALBUMIN 36 NORMAL
    ALK_PHOS 469 HIGH
    GAMMA GT 24 NORMAL
    AST 28 NORMAL
    ALT 20 NORMAL

    PROFILE
    HBSAg positive
    HBsAb negative
    HBeAg negative
    HBeAb positive
    HBcAb positive.

    Please interpret the above results for me . Thank you very much

    1. Hello: You have hepatitis B, as indicated by the positive hepatitis B surface antigen (HBsAg) test, but your liver is healthy and your infection is “inactive.”
      Your ALT level of 20 shows you are not experiencing liver damage. Your viral load (HBV DNA) is probably low because you test positive for the hepatitis B “e” antibody (HBeAb).
      Keep getting monitored regularly, avoid alcohol and cigarettes, eat healthy foods and practice safe sex.
      Also, if this was your first hepatitis B test, you should get tested again in six months to see if this is a new, acute infection or if it is a chronic infection.
      Good luck.

      1. Thank you very much. I’m now about to go for another test from my doctor.
        I hope the Almighty God lead you to find the cure soon.

  104. Hello,

    My son (13 years) has Hepatitis B since last one an half year, and he has taken baraclude ( entecavir)0.5mg, for about 15months, and now i got the medicine of entecavir (entavir)from India. my question is this whether both medicine are the same and don’t have any side effect?
    moreover can you help me to tel me for how long he should take the medicine?
    thanks for your cooperation in advance.

    1. Hello: Generally, medical guidelines recommend treatment only if someone is experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women (and children) they are up to 19. These numbers can vary from lab to lab. Do you know what your son’s ALT/SGPT levels were? And have the antivirals helped reduce any liver damage?
      Generally, antivirals such as entecavir are very good at lowering viral load, but they work for only as long as he takes them. Please consult with your doctor and see what his ALT levels are to determine if he needs to continue treatment.
      If you live outside the U.S., you may want to review the World Health Organization’s hepatitis B monitoring and treatment guidelines with your doctor (at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/)
      I believe entecavir would be the same wherever it is manufactured, but you may want to research the drug’s manufacturer to make sure they are legitimate. Generally, entecavir causes very few side effects. If your son is experiencing any side effects, please consult with your doctor.
      Good luck.
      If you ever do, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir. Good luck.

  105. Please can someone with the chronic hepatitis recover or cured ?
    If yes then is that person take vaccine after he is cured from hepatitis ? Thank you

  106. Hi
    I have chronic Hep B
    Have been taking enticavir for years and viral load below detection it
    But still positive
    How long till I have till there is a cure and are there any sample medication I can take, desperate to get cured, father died of cancer and and anxious it’s on my genes

    1. Hello: I’m glad the entecavir has worked to reduce your viral load to undetectable levels. Hopefully your liver enzyme (ALT/SGPT) tests have not found any liver damage while you’re been on the antiviral?
      Unfortunately, there is no new medication that will totally eradicate hepatitis B, you are taking one of the best antivirals available. Please continue to get monitored regularly, especially with your family’s history of liver cancer.
      For the latest on drugs in development, please visit: http://www.hepb.org/treatment-and-management/drug-watch/
      Good luck.

  107. sir i am 27 Year old infected with hepatitis b. my AST Is 31.6 and ALT is 55.6
    HBeAg is non reactive and Anti HBeAb is positive and fibroscan 5.6kpa(median stiffness) and IQR is 0.4kpa
    please sir suggest me what my reports indicate?

    1. Hello: Your liver enzyme (ALT) level at 55.6 suggests there is some minor liver damage occurring. Please keep getting monitored. Do you know what your viral load (HBV DNA) is? You may want to consider treatment, based on what your doctor recommends, if your viral load is above 2,000 IU/mL and your ALT level continues to be high. Good luck.

      1. Hello: That is a moderately high viral load (HBV DNA). What is important is to get tested for any signs of liver damage. This is indicated by the amount of liver enzyme ALT (also called SGPT) in your blood. Liver cells release ALT when they are damaged. A simple blood test measures the ALT in your blood. Health ALT levels for men range up to about 30 or 40, and for women up to 19. Good luck.

  108. hello,
    birinapant is also lost in drug watch like arc520…do you think we will have functional cure one day?? maybe 7-10 years later??

  109. Hi,
    we pray for your success. I am a patient of chronic Liver disease and my current age 30.

    Ultrasound shows My parenchymal ecotexture coarse.

    My fibroscan result : 10 kpa in 2015 // 8.1 kpa in 2016 june // 8.6 kpa in 2016 september.

    Viral load : 12 IU/ ml (doctor said low)

    Although ALT/ SGPT/ serrum level normal.

    Now I am taking anti viral once a day. Is there any future medicine to stop/reverse my liver fibrosis ?

    A patient like me can expect how many maximum years to live ?

    Doctor said It did’nt form cirrhosis yet but F2-F3 level fibrosis. So Within How many years It will form cirrhosis or whether it is a continuous process ?

    May Allah bless you…

    1. Hello: Generally, medical guidelines recommend treatment only if you are experiencing liver damage. Despite your Fibroscan, your liver enzymes (ALT/SGPT) do not show any current liver damage. When liver cells are damaged, they release ALT into the bloodstream and yours are normal. However, your doctor may be recommending treatment if you have a family history of liver cancer or other physical conditions. Keep in mind that antivirals work for only as long as you take them. Generally, doctors try to postpone treatment for as long as possible because once you start antivirals, you need to take them for several years, which is why they generally wait for signs of liver damage.
      Keep in mind that many people with hepatitis B live long and healthy lives, so eat healthy foods, and avoid alcohol and cigarettes. Also, keep getting monitored.
      I don’t know where you live, but you may want to review the World Health Organization’s hepatitis B treatment guidelines with your doctor. They are at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
      Good luck.

      Good luck.

  110. I am suffering from hepatitis B. I am 27 years old. I am unmarried. Is it possible to save my wife from this disease. Is it possible to save our child from hepatitis B.

    1. Hello: Yes, you can marry and have children if you have hepatitis B! But there are some important steps to take to make sure your partner and your future children do not become infected.
      Before you marry or have sexual relations, you must make sure your partner is vaccinated against hepatitis B and has enough hepatitis B antibodies (HBsAb) to protect them.
      Have them go to a doctor and get screened for hepatitis B. If they are not infected and haven’t been vaccinated in the past, they should get the three shots of the vaccine. (They may have been immunized during childhood.) The second shot is given 30 days after the first, and the third shot is given six months after the first shot.
      About one or two months after the third vaccine shot, have your partner screened for hepatitis B antibodies/titers. Or, if they were immunized in the past, have them tested now to make sure they have enough antibodies to protect them. The number of antibodies should be more than 10 mIU/mL. That means they have enough antibodies to fight off infection.
      If they were immunized long ago, their antibody levels may be under 10, if that is the case talk to your doctor and get one more hepatitis B vaccine shot (called a booster), and then test again to see if the antibodies have increased.
      Until you are certain that your partner has enough titers to fully protect them from hepatitis B, you must practice safe sex and use a condom. Good luck!

  111. hi I’ve been taking FTC AND 3TC and lamuvudine for hepatitis b is that correct coz it was prescribed by doctor. and how long the phase iii of human trials lasts?

    1. Hello: Are you also infected with HIV? The antiviral drugs you were prescribed — emtricitabine (FTC) and lamivudine (also called 3 TC) — are often used to treat HIV. If you only have hepatitis B, the recommended antivirals are either tenofovir (TDF) or entecavir. Lamivudine is no longer used to treat either hepatitis B or HIV because it can cause a high rate of drug resistance. Good luck.

  112. no I’m not hiv positive, is it possible to change medication since its been a year taking it? and are there any effects that can be caused by the treatment I’m taking?

    1. Hello: The two recommended antivirals for hepatitis B treatment are either entecavir (Baraclude) or tenofovir (Viread.) However, a new formulation of tenofovir, called TAF, has recently been approved in the U.S. and Japan. TAF reaches liver cells more efficiently and therefore requires a lower dose of tenofovir. Tenofovir over time can contribute to bone loss and kidney problems, so this low-dose formulation is welcome news. Good luck.

  113. hi doctor i am hbv inactive carrier in my country ultrasound and HBV dna count are so expensive and i cant pay it. i am inactive carrier for more than 16 years. in this years i just chek my ast/alt every 6 mounth or once a year and they are normal do you think is that enough that i just chek my ast and alt every 6 mounth??

    1. Hello: If you can do nothing else, getting your liver enzymes (AST/ALT) tested every six months is excellent because it should indicate if there is any liver damage occurring. And, as you probably know, eat healthy foods and avoid alcohol and cigarettes. Good luck.

  114. Hi, Iv been diagnosed hep. b chronic few months ago ( may 2016) because when I went to the hospital in 2010 the doctors told to me that I have hep. B acute not the chronic, 6 years later I felt the same symptoms as 2010, but this time the Doctor told me that I catched my hep.b on my birth, so he decided that I may have to take medicines and a scam exam of my liver… the question is they didn’t make any scam exam and I’m not taking any treatment ( medicines) , I just go there to make some blood tests… the question is : I shouldn’t take the medicine and make a scam exam of my liver??!

    1. Hello: To find out if you are experiencing any liver damage from your hepatitis B infection, doctors recommend getting an ultrasound and having your liver enzymes tested. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by the ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. If you ever do, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir. Good luck.

  115. I have been taking Tenofovir for almost 3 year now. My LTF are normal and HBV DNA is saying inhibition detected which I presume not detectable as doctor also says so. But, doctor still recommends me to take the medicine. So, I just want to know for how long i need to take the medicine. Because I m afraid that long term therapy might also have site effects.
    Please advice me.

    1. Hello: The most effective treatment currently available are antivirals, including tenofovir, which quickly stop the virus from replicating. The trouble is, antivirals work only for as long as you take them. If you were experiencing liver damage and high viral load, your doctor prescribed tenofovir to reduce your risk of liver damage. The doctor probably wants to keep you on it to prevent a reactivation — a sudden increase in viral load and liver damage.
      Tenofovir over time can cause bone loss and kidney damage. The U.S. Food and Drug Administration recently approved TAF, a different formulation of tenofovir that delivers tenofovir’s robust antiviral activity at a lower dose. However, it is currently available only in the U.S. and Japan.
      Make sure your doctor is monitoring your vitamin D level, bone health and kidney function to see if the tenofovir is causing any side effects. Good luck.

  116. Hi,

    My wife is 26 years old and pregnant from 7 weeks. During her blood test it was observed that she is hepetatis B positive we also did her liver functioning test which is normal and says it is not yet chronic.
    does it cause any harm if we go with some medication like tenofovir,do we have any possibilities to make it negative as it seems to be an early stage of it.

    1. i have done my hepatitis test which is negative and am going for vaccination now.

      Your suggestion will be greatful in this regards.

      1. Hello: Good for you, please get your immunization and know you and your family will forever be protected against this infection. Good luck.

    2. Hello: I’m glad your wife was tested and her hepatitis B was identified. The most important thing to know is that your newborn must be vaccinated against hepatitis B with the first vaccine shot within 12 hours of birth, and also be given a dose of HBIG (hepatitis B antibodies) if it’s available. This will prevent your baby from becoming infected with hepatitis B.
      However, if your wife tests positive/reactive for the hepatitis B “e” antigen (HBeAg) and has a high viral load, the immediate treatment with vaccination and HBIG may not be enough. So please have her viral load (HBV DNA) tested to find out if she has a high viral load. If it is higher than 200,000 IU/mL, then she should be treated with an antiviral, such as tenofovir. (For more information on this, please read: http://www.hepb.org/blog/expert-calls-for-viral-load-testing-in-all-pregnant-women-with-hepatitis-b/)
      Because her liver enzymes/function is normal, she does not require treatment at this time. The only reason she would need treatment is if she has a high viral load. Good luck.

      1. Hi Team,

        Thanks for your valuable suggestion below is the test results for her Hepetitis profile. Request you to please suggest what should should we do next. is it curable..?

        Hepatitis B Core Antibody Total (HBcAb­ Total)(ELISA) – 0.03
        Hepatitis B Envelope Antigen (HBeAg) – 0.17
        Hepatitis B surface Antibody Total (Anti HBs)(ELISA)
        – 0.05
        Hepatitis B surface antigen (HBsAg) ­ Screening(Elisa)- 8.65
        Hepatitis E Virus (HEV) Antibody ­ IgM (ELISA) – 0.13

        Hepatitis B Viral load ­ Quantitative ­ PCR
        Hepatitis B Virus Quantitative – 202 IU/mL
        Hepatitis B Virus Quantitative – 1171 Copies/mL

        1. Hello: It appears you have “inactive” hepatitis B. This means your immune system is working well to contain or control the infection and suppress viral replication. Your viral load is low, at 202 IU/mL, you test positive for the hepatitis B “e” antibody, and in a separate post you indicated your liver enzymes (ALT or SGPT) are normal, which indicates your liver is healthy. Keep up the good work, avoid alcohol and cigarettes, eat healthy foods and practice safe sex. Good luck.

        2. Hello: Unfortunately there is no cure for hepatitis B, however there are effective antiviral treatments if someone ever requires treatment. This person appears to have “inactive” hepatitis B with a near undetectable viral load (HBV DNA). As long as her liver enzymes are healthy — with a SGPT/ALT level below 20 — she is doing fine. Continue to have her monitored regularly and make sure she eats healthy foods and avoids alcohol and cigarettes of course. Good luck.

    3. Hello: There is no cure for hepatitis B, and even a good antiviral such as tenofovir will not make the infection go away. Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for women they are up to 19, and you report that your wife’s liver is not affected by her infection.
      The most important thing to do now is to get your wife’s viral load (HBV DNA) tested. When women have high viral loads, more than 200,000 IU/mL, their newborns can become infected even if they are immunized at birth and treated with HBIG (hepatitis B antibodies) to prevent infection. (Read more on this at: http://www.hepb.org/blog/expert-calls-for-viral-load-testing-in-all-pregnant-women-with-hepatitis-b/)
      In addition to getting her viral load tested, you must make very sure that your baby is immediately immunized with the first hepatitis B vaccine dose within 12 hours of birth and also given a dose of HBIG (hepatitis B antibodies.) Otherwise, the baby is at high risk of infection from exposure to the mother’s blood and body fluids during delivery.
      Good luck, and congratulations.

  117. I have been diagnosed as HBV carrier since year 2000 during a pre-employment medical exam. My possible hiring was cancelled due to the fact that some countries specially the Gulf countries do not allow HepB carriers to work in their country (a form of discrimination to carriers like me). Fortunately, I was accepted by a company who does not discriminate people like us as long as we are qualified, considering the fact that my job is not related to food and medical industry and chances of me spreading the virus is almost nil. We are required to undergo routine annual medical exam and so far all indications of my health is normal based on blood analysis, liver function and ultrasound. However HBsAg remains reactive and HBcAg non-reactive. My health at my age of 54 is remarkably good and in tip-top shape aside from the mentioned condition. I am very happy and excited to see the success of your drug that will eventually put HepB virus to extinction. I will be praying for your success and hopefully I will be able to take the drug you are developing. ore power to you.

    1. Hello: I am glad to hear your story, and to learn there are companies with the integrity and courage to hire people with hepatitis B. As you may know, people with hepatitis B do not spread the infection even if they work as doctors or nurses, or in the food industry. We hope to see an end to discrimination against people with hepatitis B around the world soon. Good luck.

  118. Hallo I tested positive for Hep B in 2016 May. But I could not know if it were acute or chronic. Now six months later, which test(s) can I carry to know if i have recovered or not. Can my surface antigen Hep B Ag still test positive even if i have recovered?
    For how long more can the world expect that maiden cure to finally be unvailed

    1. Hello: You must have a blood test for the hepatitis B surface antigen (HBsAg) again. If HBsAg is present after six months, it means you have a chronic infection and may have been infected during early childhood. If you still are, please have your liver enzymes (called ALT or SGPT) tested to find out if the infection is harming your liver. We hope in the few years that a cure will be developed for hepatitis B. Good luck.

  119. hello, after recovery from acute hepatitis b, are you safe from the infection? and can you transmits it to other person? and what are the sign of the recovery from the infection?

    1. Hello: The key indicator that you have recovered from a hepatitis B infection is the loss of the hepatitis B surface antigen (HBsAg) and appears of hepatitis B surface antibodies (HBsAb). It is the sign everyone with hepatitis B hopes for. Once you have lost HBsAg and gained surface antibodies, you cannot spread the infection to anyone else. Good luck.

  120. I have hepatitis b,and i have a lot of pain inside my write side libs in the chest, and when they tested the liver functioning tests they said my live it is fine what could be the course of the pain thank you.

  121. Hallo good day to you. Of late I have been experiencing painful ribs on the right hand side. If I touch my ribs (bones), some of them feel for painful and hurting with a burning sensation. Could this be related to my liver? One week ago I did LFT the results showed the following:
    total protein 7.36
    ALT 17.2
    AST 16.8
    BILLIRUBIN DIRECT 4.1
    BILIRUBIN TOTAL 12.8
    NB I tested positive for Hep B in May 2016 but have not done any other test(s)
    What could be causing the pain to the bones?
    Thanks for helping

    1. Hello: Hepatitis B rarely causes physical, abdominal pain (see: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/), which is why it’s called the “silent” infection.
      Also, your ALT levels, which indicate if the infection is harming our liver, are well within the normal range. Liver damage is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see if the abdominal pain is caused by another medical condition, not related to hepatitis B. Good luck.

  122. Hello Dr.,

    My husband was diagnosedwith HBV in July 2016,he is 37 years old.
    His SGPT level is 35 IU/ml (it was 39 in july 2016), his viral load is 56.1 IU/ml (log 1.5) (it was 172 IU/ml in july 2016), his HBS antibody is 0, and HBS antigen 6292.38 S/CO (it was 5545.56 in July 2016). Our Dr. Is asking us to start with interferon treatment because of the antigen levels but we need more than 1 opinion on his case.
    My husband doesn’t smoke, doesn’t drink alcoholic and we eat healthy.
    Please reply to us, we live in fear.

    1. Hello: Before I give you advice, can I ask if your husband has hepatitis D (as well as hepatitis B). Your doctor may be recommending interferon because he has a coinfection involving both viruses. It is abbreviated HDV.
      If your husband only has hepatitis B, it is important to know that not everyone with hepatitis B requires treatment, and many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme SGPT. Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30 to 40, and for women they are up to 19. Because your husband has a low viral load and his SGPT level is in the healthy range, he may not need treatment at this time. Good luck.

  123. hould i abandon my course in uganda christian university of bachelors in education to save for my family? the pain in the lower abdomen is too much though I’m on antiretroviral 6 months

    1. Hello: Hepatitis B is called the silent infection because it rarely causes side effects, such as abdominal pain. Our livers have very few sensory nerves near them, so we rarely feel any physical discomfort from a hepatitis B infection. If you continue to have discomfort, I recommend that you see your doctor. A medical condition unrelated to hepatitis B could be the cause. For more information about abdominal pain and hepatitis B, read: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/
      Good luck.

    1. Hello: Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment.
      If you are unsure of what your blood test results mean, please visit: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
      Good luck.

  124. What could be deit for hepb claint?What is alfa feot-protain assessment?Can wornout liver cells be recovered with ARV’S?

  125. In 2016 got to know I’m having hepatitis b virus when I got sudden offset of not working of muscle I had not been able to even sit, four limbs were not working at all but internally feeling good, I went through test got to know it hypokalemia(deficiency of potassium) along with I am having hepatitis b virus. Finally been told your liver is taking more potassium leading deficiency in body, I advised to take potassium Cyrup and recovered very soon, coming to hepatitis she told no medication required right now as their is no damage due to virus but come every six months for test.i’m 24 year old, feeling no pain no symptoms. Please tell me how to be remain same any food inclusion any abstinence.

    1. Hello: I’m glad you are getting monitored every six months, it sounds like you have a good doctor. There are no specific foods you should avoid (other than alcohol and cigarettes). Just try to lead a healthy lifestyle and eat healthy, low-fat foods with lots of fruits and vegetables. Good luck.

  126. I’m a Hepatitis B positive my viral load test show 355 IU/ML can you advise me, before four years it was 614 IU/ML

    1. Hello: Your viral load (HBV DNA) has remained low, which is excellent news. A change from 355 to 614 is not considered medically significant. Viral load has to increase ten-fold or even 100-fold to be significant. I hope you’re getting your liver enzymes (ALT/SGPT) monitored also to find out if you are experiencing liver damage. Good luck.

  127. I am 28yrs and was diagnosed with hepatitis and the doctor prescribed l take livolin forte but I use to have a runny tummy but now I have constipated and feels very uncomfortable in my Tommy. I will usually feel the urge to go to the ladies but I find it difficult to ease of urinate. I would be glad if a cure is found soon. Thank you

    1. Hello: Unfortunately, the herbal supplement your doctor recommended will not cure your hepatitis B and clearly is not making you feel better. The National Institutes for Health has published fact sheets on various herbal supplements, the home page is at: https://nccih.nih.gov/health/herbsataglance.htm
      Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver. Good luck.

  128. Hi dr

    I talked to my uncle back home iran

    He also a family dr

    He knows about my situation and I told my uncle
    I wish I had hep c because there is cure for it
    And my uncle told me be happy u have hep b not hep c because that’s not very good to have

    My question might be sorry stupid to ask

    But your dr and have lots experience
    U think better have hep b or hep c ( I know Both not good to have but just wnana know )..

    I pray to god also cure for hep b find soon

    Thank u

    1. Hello: It doesn’t matter, neither hepatitis B nor C is good to have. Yes, there is a cure for hepatitis C, but it is extremely costly still. Just focus on taking care of yourself, avoid alcohol and cigarettes, and eat healthy foods. And, make sure your family members have all been tested for hepatitis B and vaccinated if needed. Good luck.

  129. Hi,
    Me my elder brother and my mother are effected by hep b and we got it from our mother please find some medicines for people like us so we can get 100 % cure and in how many years we can expect a 100% cure😢

    1. Hello: There is no cure yet for hepatitis B, however there are two very effective antivirals -– entecavir and tenofovir (Viread) and its TAF formulation that was recently approved by FDA –- that quickly reduce your viral load (HBV DNA) and your risk of liver damage. To find out the latest in new hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
      Experts predict a cure will be developed in the next few years, we are optimistic. Good luck.

  130. Thank you for your great information.
    Could you advise me on the best Heb B treatment that is available please.
    I have recently diagnosed with Chronic Heb B.
    I was told I have a high viral load in my liver with no symptoms.
    I am 25 years old and fit and healthy. is the recommendation to start the treatment now? what would be the best treatment if money was not the issue.

    I look forward for your reply,

    Kind regards

    1. Hello: Generally, medical guidelines recommend treatment only if you are experiencing liver damage, even if you have a high viral load (HBV DNA). This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. If your ALT/SGPT levels are normal, it may not be advisable to start treatment yet, especially given your young age.
      If you ever do require treatment, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir.
      Remember that most people with hepatitis B live long and healthy lives, especially if they avoid alcohol and cigarettes. Good luck.

  131. Hello I have hepatitis B and I was to travel abroad but visa was cancelled and looking for fast treatment..
    Help me team

    1. Hello: Unfortunately, there are some countries, primarily in the Middle East, that unfairly discriminate against people with hepatitis B — even though they pose no health threat. As a result, they do not issue work, student or other type of visas. Unfortunately, there is no cure or fast treatment that will make your hepatitis B go away. The first thing you should do is determine if you have a new, acute infection, which will go away in about six months, or whether you have a chronic or long-term condition.
      Please get tested again in six months, to see if your infection has gone away. If it has not, make sure your doctor performs other tests to see if the infection is harming your liver. Good luck.

    1. Hello: When you have your liver enzymes tested, they tell you whether any liver damage is occurring at the time the test was performed. It’s like a snapshot of your liver health. However, if you liver experienced inflammation or fibrosis in the past, an ALT or SGPT test will not show it. This is why it’s important to be regularly monitored so over time your doctor can determine the state of your liver. If your liver test consistently shows healthy ALT/SGPT levels, then you can assume your liver is healthy. One more test you should have done is an ultrasound test of your liver, this will provide one more perspective on your liver health. Good luck.

  132. Please was diagnosed of hbv 2012, hbv +++, did liver function test and ultrasound the doctor said its normal,he also said I should take tenofivir+entracitabin for 6months…will it really cure d virus

    1. Hello: There is no cure for hepatitis B, the antiviral medication that your doctor recommended however will lower your viral load (HBV DNA) and reduce your risk of liver damage from the infection. However, antivirals work for only as long as you take them, and medical guidelines do not recommend treatment with antivirals unless you are experiencing liver damage, which you are not based on your liver function tests.
      Keep in mind, many people live long and healthy lives with hepatitis B especially if they avoid alcohol and cigarettes and eat a healthy diet. Generally, liver damage is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19.
      Taking antivirals is a long-term commitment, so doctors generally do not recommend them unless there is evidence of a high viral load and liver damage. Please talk to your doctor about whether treatment is necessary at this time. If you live outside of the U.S., you may also want to review World Health Organization guidelines for hepatitis B treatment with your doctor. They are at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
      Good luck.

  133. Hi . My name is Isaiah. l was diagnosed Hepatitis B positive last year October and my Doctor advised me to take Essentiale Forte 300mg. daily. When l took it generated a lot of heat in whole body Pls what is your advise . Should l continue taking it? Thanks

    1. Hello: Unfortunately, the herbal supplemental that your doctor recommended will not cure your hepatitis B. The National Institutes for Health has published fact sheets on various herbal supplements, the home page is at: https://nccih.nih.gov/health/herbsataglance.htm and none of them were found to be effective against hepatitis B.
      Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your hepatitis B and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver. Good luck.

  134. Hello
    thanks for your effort to looked for the hep b cure
    I tested for hep b and was positive and wen I proceeded to do liver functionso tests and hap b antigen (eclia, it’s came out negative and also anti-hep b core anti body (igm eclia) also came out negative
    but anti-hep B core anti body igm&igm eclia came out positive
    does this mean I should begin on medication
    and which one is suitable

    but the consultant also side am having chronicso type which I might have acquired at birth
    Does it mean am gonna test positive through out my life time
    or there US possibility of the virus to clear

    1. Hello: When you test positive for the hepatitis B surface antigen (HBsAG), it means you are currently infected with hepatitis B. Most healthy adults who are infected are able to get rid of the virus on their own within six months. This is called an acute infection.
      However, if you continue to test positive for HBsAg for longer than six months, it is considered a chronic infection. It means you were probably infected at birth or during early childhood, when your immature immune system could not fight it.
      Knowing whether your hepatitis B is acute or chronic will help you and your doctor determine your next steps. Please get tested again in six months to find out if it’s chronic or acute. If you are unsure of what your blood test results mean, please visit: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
      Good luck.

  135. LFT test Dec 2016
    Total bilirum-13.1µmol/L
    Direct bilirum-2.3µmol/L
    Indirect bilirum 10.8µmol/L
    Total protein 66g/l
    Albumin 43g/l
    Globulin 23g/l
    SGOT/AST 19.8IU/L
    SGPT/ ALT 23.0IU/L
    Alkaline phosphatase 267.41IU/L

    LFT test Aug. 2014
    Total bilirum 9.6Umol/L
    Direct bilirum 1.4Umol/L
    Indirect bilirum 8.2Umol/L
    Total protein 62.4g/l
    Albumin 44g/l
    Globulin 18g/l
    AST 23.6U/L
    ALT 17.5U/L
    GGT 22.2 U/L
    Alkaline phosphatase 480 U/L
    they used different test solutions and different reference scales…..all were within the range except tha alkaline phosphatase that was high in 2014
    the doctors keep saying its normal….please what do you think?

    1. Hello: I can comment only on your liver enzyme result, (SGPT/ALT), which has been consistently within normal range over these last two tests, indicated your liver is healthy. Keep getting monitored (hopefully more frequently than every two years!) Good luck.

    1. Hello: I am so sorry to hear that you face economic and professional discrimination because of your hepatitis B status. You must fight the discrimination and ignorance behind these government policies. No one else will do this for you. In the Philippines, there is an organization working to eradicate hepatitis B discrimination. Please join them and lend your voice, experience and talents to this important battle for freedom and civil rights. Their contact information is below:
      Yellow Warriors Society of the Philippines
      https://www.facebook.com/YellowWarriors?fref=ts

    1. Hello: How about simply living with hepatitis B. The vast majority of people live long and healthy lives with hepatitis B, especially if you eat healthy foods and avoid alcohol and cigarettes. Don’t let hepatitis B define you. It is a part of you, but there is so much more…. do not give into despair.

  136. I’m just scared, pls this is my result,
    Hepatitis B’s ag=positive
    Hepatitis b envelope A.g=negative
    Hepatitis b core Ab=positive
    Hepatitis b Ab-negative

    1. Hello: When we are infected with the hepatitis B virus, we test positive or reactive for the hepatitis B surface antigen (HBsAg). Another of the viral antigens that labs test for is the hepatitis B “e” antigen.
      As our immune systems start to fight the infection, they produce antibodies to eradicate or get rid of the hepatitis B antigens. It’s a good sign that you test negative for the hepatitis B “e” antigen (HBeAg). It can mean your viral load is low.
      Is this the first time you have been tested for hepatitis B? To know if you were recently infected and have a short-term “acute” infection, you need to be tested again in six months.
      When healthy adults are infected, it takes about six months for their immune systems to get rid of the infection. When newborns or children are infected, their immature immune systems don’t recognize and fight the infection and it can become chronic and last for many years.
      Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. Good luck.

  137. What can i do, i dont know if my liver is affected, i feel pain in my lower abdomen and my liver side, (right and left side) thank you for your good work.

    1. Hello: To find out if you are experiencing liver damage, medical guidelines recommend an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment.
      If you ever do, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir.
      Hepatitis B rarely causes abdominal pain, because there are very few sensory nerve endings around the liver. Please talk to your doctor and see if another medical condition is causing your discomfort. Good luck

  138. hi I’m hepatitis b positive
    Eagerly waiting for permanent cure hope God make the efforts come true for all diseases
    Please inform wen the cure is available

  139. Hello,

    It’s a really wonderful news this about the possible cure of hepatitis b. I am 30 years old young man and am a hepatitis be carrier. I found it in 2014 and, fortunately, I’ve been health so far. I have a new girlfriend and she was vacinated against hepatitis b today and the medical personel says she has to get two more vacines in the next two months. Is it wise to kiss her or have unprotected sex before the last two months? Thanks in advance.

    1. Hello: The normal vaccination schedule takes six months — the second shot is administered 30 days after the first, and the third shot five months later. The CDC recommends an accelerated vaccine schedule for special situations: ” An approved accelerated vaccination schedule can be used for people traveling on short notice who face imminent exposure or for emergency responders to disaster areas. The accelerated vaccination schedule calls for vaccine doses administered at days 0, 7, and 21–30; a booster should be administered at 12 months to promote long-term immunity.”
      It is alright to kiss her with risking spreading the infection, but before you have unprotected sex, you need to make sure she has enough hepatitis B surface antibodies to protect her against infection. About one to two months after her third vaccine shot, she should be tested for surface antibodies (HBsAb). If she has at least 10 mIU/mL of HBsAb, you can safely have unprotected sex without the risk of infection. Good luck.

  140. I am 27 years old asian male.I am first diagnosed with hbv in 2007 but at that time i was in inactive phase.Now i want to go abroad i did my complete medical and I am diagnosed by chronic hbv.According to my doctor firstly I had started Viread 300mg for just 4,5 days then again I visited to a known Gastrologist,he said there is no need to be worry and he stopped my medicine Viread and he just gave me Evion 400mg and Nexum 40mg. My results are below. Dna viral load 3550, fibroscan 5.4 kpa Alt 43, Antie hbe positive, HBeag negative, Heamogolbin 15.9. I need your suggestions.pls tell whether I continue Viread or not and what kind of side effects I can have after using it.

    1. Hello: I tried to find both drugs, and neither are scientifically proven to being effective against hepatitis B. There are two drugs that medical guidelines recommend for hepatitis B — entecavir (brand name Baraclude) and tenofovir (Viread), which your first doctor recommended. Antivirals work for only as long as you take them, and stopping antivirals can be dangerous and cause a “flare” — a sudden increase in viral load and possible liver damage. Because of this, doctors recommend antivirals only if patients are experiencing liver damage (indicated by high liver enzyme or ALT levels).
      Your ALT level is not very high, healthy ALT levels for men range up to 30 to 40.
      Instead of starting treatment at your young age, perhaps it would be wiser to continue to get monitored regularly (such as every six months), and of course eat healthy foods and avoid alcohol and cigarettes.
      Also, there is no treatment that will make your hepatitis B go away (or help you test negative for the hepatitis B surface antigen, which indicates the presence of a hepatitis B infection.)
      If you have questions about when and how you should be treated for hepatitis B, please review the World Health Organization’s hepatitis B treatment guidelines with your doctor at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
      Good luck.

  141. Hello:I have hepatitis b since known 2015
    present doctor said it is normal and no medicine is required but I have dehydration and some skin problems like dry skin totally and black spots on bottom of feet and some places of body.
    Medlab clinic approaches they said cure is there ,for medicine they ask $450
    What should I do?

    1. Hello: There is no cure for hepatitis B, please do not be tricked into false claims of treatments and cures. (See: http://www.hepb.org/blog/buyer-beware-when-someone-claims-to-have-a-hepatitis-b-cure-its-a-counterfeit-drug/)
      The symptoms you have described do not usually result from hepatitis B. Please drink lots of water and if the black spots persist, please return to see your doctor.
      In the meantime, eat healthy foods and avoid alcohol and cigarettes. Good luck.

  142. I have hbv since 1995 due to operations of neck, but waiting cure of hbv but I married, I don’t have ability to share wife, I have hbv carrier but I vaccines hbv her all three shots.thanks allah mighty she didn’t infected and we have one baby but he is safe I known about hbv.inshallah one day cure hbv

    1. Muhammed I have few doubt’s about this..
      My age is 22 ,
      If I married how to manage hbv.
      How is our life?
      How is journey from 1995 to 2017 ?
      Pls explain detail

      1. Hello:
        Yes, you can marry and have children if you have hepatitis B. But there are some important steps to take to make sure your partner and your future children do not become infected.
        Before you marry or have sexual relations, you must make sure your partner is vaccinated against hepatitis B and has enough hepatitis B antibodies (HBsAb) to protect them.
        Have them go to a doctor and get screened for hepatitis B. If they are not infected and haven’t been vaccinated in the past, they should get the three shots of the vaccine. (They may have been immunized during childhood.) The second shot is given 30 days after the first, and the third shot is given six months after the first shot.
        About one or two months after the third vaccine shot, have your partner screened for hepatitis B antibodies/titers. Or, if they were immunized in the past, have them tested now to make sure they have enough antibodies to protect them. The number of antibodies should be more than 10 mIU/mL. That means they have enough antibodies to fight off infection.
        If they were immunized long ago, their antibody levels may be under 10, if that is the case talk to your doctor and get one more hepatitis B vaccine shot (called a booster), and then test again to see if the antibodies have increased.
        Until you are certain that your partner has enough titers to fully protect them from hepatitis B, you must practice safe sex and use a condom. Good luck.

  143. Sir, i am  having  cronich hepatitis b 
    My blood test is showing following results:-
    hbsag  -positive,
    anti hbe- reactive
    Viral load-28700 iu/ml
    ALT.  – 41
    Total protein-8.3 high
    Red blood cell count- 5.94mil/ul high
    Red cell distribution width-14.3 % high
    now please advice me, do i need any treatment? I am 33 years old healthy man, having normal liver in ultrasound sonography

    1. Hello: I will address only your liver/hepatitis B test results.
      Your test results show your liver is healthy, which is excellent. Your viral load is a little high, especially considering you have developed the hepatitis B “e” antibody (anti HBe), which usually leads to a lower viral load.
      Your ALT of 41 is a liver enzyme test that looks for liver damage. Our liver cells release ALT into the bloodstream when they are damaged. Normal or healthy ALT levels range up to 30 or 40 for men.
      You probably do not need treatment at this time, but that also depends on your family history of liver cancer. Please talk to your doctor about your results.
      It is important that you avoid alcohol and cigarettes, eat healthy foods, and of course practice safe sex. I hope your family members have all been tested and vaccinated. Good luck.

  144. Thank you very much sir, i hope the research will complete until i need it, our scientists are very close to the target

  145. Andand, first you have believe that you hbv carrier and its a part of our life but follow the instruction of best doctor of liver specialist.andand when you merry, plz vaccination of all shots which was recommended by CDC or WHO, believes yourself, one day we eliminate hbv in our world…….enjoy your life which is given by allah might

  146. I got menangaits vaccination. yet I’M Hepb positive on ARV.I feel upset now.How have some people live over 10 years when positive? And on treatment?

  147. Hello. My doctor told me to have a test and this is the result.
    Hbsag non reactive
    Anti hbs H 2593.0 IU/L Reactive
    Anti Hcv non reactive
    Please tell me what is that mean.
    Because my doctor tell me to get a test again.

    1. Hello: The hepatitis B surface antigen (HBsAg) is the key indicator of a hepatitis B infection. To test negative (nonreactive) for HBsAg and positive (reactive) for the hepatitis B surface antibody is excellent, it means you do not have hepatitis B. The hepatitis C antibody test (anti HCv) tests for hepatitis C, and you are not infected with hepatitis C either. Wonderful news, good luck!

  148. People around my area commonly are dying of kidney failure,liver complications,swollen stomach.Couldn’t they be dying of hepatitis B virus ?What could be causing this deaths?

    1. Hello: There are many things that can cause the symptoms you have described, ranging from malnutrition and a host of infections. We hope for a cure for hepatitis B and many other diseases soon. Good luck.

  149. I am hepatitis B carrier for long years..but my body is good..sadly i cant go on to other country to work because of this..can be possible that the virus in the blood cure?what medicine can i take.. please advice me thanks and more power

    1. Hello: Unfortunately, there is no cure for hepatitis B yet, nor is there a drug that makes the hepatitis B surface antigen (HBsAg) go away, and this is the antigen that indicates if you are infected or not.
      We are optimistic that in the next few years a cure for hepatitis B will be developed, and this unfortunate and unnecessary discrimination against people with hepatitis B will disappear. To keep up to date with the latest in drug developments, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
      Good luck.

  150. Periodically I urinate coffee brown.Yet after painful stomach ache and recently I was mountainside against menengaitits vaccine.All previous pain have subsided.I feel better.

    1. Hello: Please talk to your doctor to see if the symptoms are caused by hepatitis B or another medical condition. Good luck.

      1. Hello I’ve been diagnosed hepa B chronic last year.when I’m applying to work abroad..my doctor said I’m just a carrier because the virus doesn’t multiply..

          1. Hello: A small percentage of people do eventually clear hepatitis B (ultimately losing the hepatitis B surface antigen – HBsAg) on their own. Researchers predict a cure will be developed in the next few years. We remain hopeful. For updates about hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
            Good luck.

        1. Hello: When you test positive for the hepatitis B surface antigen (HBsAG), it means you are currently infected with hepatitis B. Most healthy adults who are infected are able to get rid of the virus on their own within six months. This is called an acute infection. However, if you continue to test positive for HBsAg for longer than six months, it is considered a chronic infection. It means you were probably infected at birth or during early childhood, when your immature immune system could not fight it.
          Knowing whether your hepatitis B is acute or chronic will help you and your doctor determine your next steps. Have you been tested again since your test last year? If not, please get tested again to find out if it’s chronic or acute. If you are unsure of what your blood test results mean, please visit: http://www.hepb.org/prevention-and-diagnosis/diagnosis/hbv-blood-tests/
          If you should continue to test positive for HBsAg and have a chronic infection, your doctor should conduct other tests to find out if you have experienced any liver damage.
          There is no cure for hepatitis B currently, but experts predict a cure should be developed in the next few years.
          Good luck.
          Good luck.

  151. Hi,

    Would like to seek your help in analyzing my medical result for hepatitis b. I am from philippines 35 years of age.

    LABORATORY RESULT

    ANTI HBs – Non Reactive 0.80

    HBsAG – Reactive 3640.81

    Anti Hbe – Reactive 0.01

    HBeAG – Non Reactive 0.32

    Anti HBc IgM – Non Reactive 0.07

    Liver ultrasound result—-Normal

    Is there a chance that i could get rid of this desease? Any ways that i can cure from this? I am ligible to get vaccinated for hep b to eradicate this virus and prevent damage for my liver.

    Thanks

    1. Hello: Unfortunately, getting a vaccination against hepatitis B when you are already infected will do nothing.
      The good news is your hepatitis B infection is not causing any liver damage, as indicated by your normal ultrasound. I encourage you to eat healthy foods and avoid alcohol and cigarettes, and get monitored regularly to protect your health. Good luck.

      1. My doctor advised me to take baraclude, is there a chance in taking this drugs will help me eradicate from this desease?

        1. Hello: There is no cure for hepatitis B yet, but the antiviral entecavir works to quickly lower your viral load (the amount of virus in your body) and it reduces your risk of liver damage. Keep in mind that treatment is recommended only if you have signs of liver damage, such as liver enzyme (called ALT or SGPT) levels that exceed 19 in women and 30 in men. Talk to your doctor to make sure you need treatment, because once you start taking antivirals, it’s a long-term commitment because they only work while you are taking them. Good luck.

  152. Hi I am hepB positive this was happened twice before I accept the truth, mid 2012 is my first med examination for abroad but I have failed by this disease and have dilemma on it so I ignored coz it doesn’t make sense coz I don’t feel pain at all. Last year mid 2016, second med examination I’ve got the same results and I feel bad of this so frustrating. I just wondering why I feel no pain? I am living with normal life..my mother told me that it was inherited to my father, is it possible? So maybe my two sisters would also have this, right? And possibly to their siblings? Pls help us through ur medical guidance on how to and what to do. Thank you and hope the cure will soon serve to infected people. More power!

    1. Hello: Hepatitis B is called the silent infection because it rarely causes side effects, such as abdominal pain. Our livers have very few sensory nerves near them, so we rarely feel any physical discomfort from a hepatitis B infection. Many chronic hepatitis B cases occur when an infected mother unknowingly infected her newborn during delivery, due to exposure to blood and body fluids. I would encourage your family members to get tested for hepatitis B, and vaccinated if they have not been infected. Yourself, please avoid alcohol and cigarettes, eat healthy foods and get monitored regularly for hepatitis B and liver damage. Good luck.

  153. hi there,

    i’m a 30 years old male, in 2012 i found out by accident that i have HBV, and i do my regular tests ever since, and my latest tests results that i just received today are ALT: 33 and HBV quantitative by PCR are 500, however i feel fine no symptoms just the Occasionally slight discomfort on the right abdomen which my doctor tells me that it’s quite allright and i don’t need to worry about a thing now. anyways i’m married and my wife is vaccinated against Virus B, and we just found out that my wife is pregnant, and i need to know all the Precautions measures i need to take to keep my wife and my baby safe from this virus during her pregnancy time, and if there are any tests she needs to do or any thing needs to be done just let me know. also there is just one more question i need to ask, could you pleas tell how much could it probably cost me to get this cure when it’s available, i know that you most probably wouldn’t know the answer, but just the estimated average or the first numbers comes in your mind, i’m from a poor country and i need to know if i can even save up to get the cure some day or just try live with it.
    thank you all for your hard work and efforts to create a Cure for this killer disease and God bless you all.

    1. Hello: First, congratulations on making sure your wife is vaccinated and protected against hepatitis B, and congratulations on your pregnancy
      I would recommend you have your wife retested for hepatitis B (here in the U.S. every pregnant woman is routinely screened for hepatitis B.) After your baby is born, enjoy and love your baby, and make sure he or she is immediately vaccinated with the first dose of the hepatitis B vaccine within 12 hours of birth. Then, make sure the baby gets the next two doses on time — the second 30 days after the first and the third five months after the second dose. That way, you never have to worry about infecting your child!
      I do not know how much a cure will cost when it is developed. Here in the U.S., I expect it will be very costly, because generally pharmaceutical companies recoup all of their research and development costs in the first years after a new drug is released. Then, it becomes a less-costly generic. However, that same drug may cost much less in Asia, for example.
      Good luck to you and your wife.

        1. Hello: There is no cure yet for hepatitis B, however there are two very effective antivirals–tenofovir (Viread) and entecavir–that quickly reduce your viral load (HBV DNA) and your risk of liver damage. How much these drugs cost vary widely and depend on where you live and what type of health insurance you have. Please talk to your doctor and pharmacist for more information.
          Remember that most people with hepatitis B live long and healthy lives, especially if they avoid alcohol and cigarettes. Live a healthy lifestyle, get monitored and you can live a full life. Good luck.

      1. Thank you very much for your kind reply, and thank you for everything you recommended i’ll do everything you recommended to keep my family safe,and…..well i will save up for the cure anyway maybe i will afford it when it’s available,
        thank you for everything, and god bless you. 🙂

  154. From NBN laboratory the only service provider cost of viral load and other testis about 180 US DOLLAR.This is expensive for third world country.Most people opt die in silence.Yet main more were vaccinated.We were so main,main had result yet and gave up.Lastly the number in the clinic continues reduce.where are they?

  155. In my first experience after 4 months treatment, doctor told me after my 4 months treatment with ARVs that my liver is now small size compared to normal size.WILL it come back to its size? why so small. when on required treatment?Keep on struggling as we struggle with the current treatment.

    1. Hello: I am sorry but I do not know what your doctor meant when he told it was a small size. When a liver is infected with hepatitis B, it can be enlarged because of the fibrosis and inflammation occurring. Please ask your doctor more questions and get him to explain what he needs. It is important that we understand our healthcare. Also, make sure you eat healthy foods and avoid alcohol and cigarettes. Good luck.

  156. Hello Dear doctor hope you doing great,
    I have question i tested hep b in 2014 and it comes positive i dont know when and where i got from it but actually i got it from unsafe sex anyway
    I aint tested how my liver goes since 2014 august than i did my okey liver blood test in January-2017 and the doctor told me that its okey and i aint have any liver damage so please do u recommend me to do ultrasound?
    The doctor told me that she didn’t find any liver damage in my blood could i go and okey with it or should i do ultrasound??

    Thank you for serving us

    1. Hello: Medical guidelines recommend both a blood test to identify liver damage and an ultrasound.
      The blood test gives the doctor a snapshot of how your liver is doing at that point in time. The ultrasound provides more information about the health of your liver over the past few years.
      Good luck.

  157. Today I paid viral load and sgpt, 2010 dollars in our pakistan which is best laboratory agha laboratory karachi..
    Waiting for cure, when game was finished in our life…..

    1. Hello: There is no cure developed yet for hepatitis B, but researchers and experts predict one will be developed in the next few years, and we remain very optimistic. Thank you.

  158. pls if one develops hbcab and hbeab, can one lose the two antibodies and under what cercumstance will one lose the antibodies
    .

    1. Hello: Once you are infected with hepatitis B, you always test positive for the hepatitis B core antibody (HBcAb). The hepatitis B “e” antigen (HBeAg) is usually present early in the infection cycle, and can disappear when your immune system creates enough “e” antibodies (anti-HBe) to clear the “e” antigen. Some HBeAg-positive patients are treated with antivirals in an effort to help their immune system clear out the HBeAg and develop “e” antibodies (called seroconversion.) If this is not successful, the HBeAg can reappear after antivirals treatment stops.
      Good luck.

  159. Today I collected my reports from lab but hbv undetectable, sgpt 69,iam taking TDF last three months but before start treatments my hbv load is 3400 and sgpt 49 but iam confuse due to increas of sgpt

    1. Hello: The fact your viral load is undetectable is excellent, however your immune system may still be fighting the hepatitis B infection in your liver. To fight infection your immune system’s T cells are targeting the hepatitis B-infected liver cells, and when liver cells are damaged, they release the enzyme SGPT. Keep getting monitored every three months, the increase in SGPT may actually be a good sign. Good luck.

    2. Hello Mohammed,

      Could you please explain what is TDF? And on what circumstances the doc prescribed it for you ?? Does it mean that the hbsag test will show negative as well and viral load would be undetectable ??

      1. Hello: TDF is the abbreviation for the antiviral tenofovir, which is very effective in lowering viral load (HBV DNA) and reducing the risk of liver damage. However, it will not make the hepatitis B surface antigen (HBsAg) disappear. Good luck.

  160. Muhammad arif I am also from Pakistan pls can you tell me from where you get taf in Pakistan and also tell me the doctor from where you getting treatment. I am from Lahore

    1. Hello: As far as we have been told, TAF (Vemlidy) has only been approved for hepatitis B treatment in the U.S., Japan and Europe. Please talk to your doctor, to see if there is a way to get the medication. Good luck.

  161. Hi there Again,
    this time i have only one question,
    lets assume that a cure is created that can entirely clear B virus from the human body, a person who had HBV for like 10 years took it and cleared out the virus from his or her body, so what are the chances for this person to have a healthy and fully function liver, i mean after 10 years of infection this virus must have caused some damage or a lot of damage, Could this be fixed once the virus is cleared, like can the liver regenerate the damaged cells again and become as good as new?…
    Thank you in advance.

    1. Hello: The good news is our livers have a tremendous capacity to repair themselves and stay healthy once a hepatitis B infection is cleared, or if viral replication is reduced through antiviral treatment. In fact, people with cirrhosis (severe liver scarring) have been able to regain liver health once they start taking antivirals and the infection in their liver decreases.
      However, once you have had hepatitis B and/or liver damage, it is important that you continue to be monitored as a safeguard. Good luck.

  162. hi, I am from Pakistan. I got to know from a medical checkup that I am a patient of Hepatitis B around 15 years ago. Then I started treatment with Zefix tablets (Lamuvidine) and I took it for about 3 years continiously. After that I left. I was very ambitious to completely eradicate it. So I again started with Homeopathy Treatment after a gape of 3 years. I took Sulfar 30X, Cardus Maranius Mother Tincture, Brionia 200 and Lycopodium 30. This was very helpful. My PCR Quantitative reduced to 0.00 IU/ml within 3 months. Then I relaxed and after a year I again went for PCR test but this time it was 72 IU/ml. I again started the above combination and within month I again went for PCR test. Now again I got 0.00 IU/ml. Now I am looking for a medicine which can work for HBsAg to make it negative but remain unlucky till now. Need suggestions. Thanks

    1. Hello: Unfortunately, the herbal supplements you mentioned do not work against hepatitis B.
      I realize your viral load (HBV DNA) appears to decline from 72 to undetectable, but that might have happened without any treatment. Our viral load varies all the time and to be clinically significant an increase or decrease of 10- or 100-fold is necessary.
      Unfortunately, there is no cure yet for hepatitis B that will make your hepatitis B surface antigen (HBsAg) disappear. Doctors recommend treatment ONLY if you are experiencing liver damage, that is indicated by a blood test for the liver enzyme ALT/SGPT or an ultrasound examination of your liver.
      If you should ever need treatment because of liver damage and a high viral load, there are two antivirals that are recommended: either tenofovir or entecavir.
      Lamivudine (Zefix) is an old antiviral that is no longer recommended because it causes a high rate of drug resistance, and it often stops working after a year or two.
      Good luck.

      1. As I had used zefix for more than 3 yers… so… has the virus in my body become drug resistant ???
        will In future no medicine be effective for me???
        How long I can live??

        1. Hello: Zefix is another brand name for the antiviral lamivudine. This was one of the first antivirals approved for hepatitis B treatment, however, IT IS NO LONGER RECOMMENDED BECAUSE IT CAUSES A HIGH RATE OF DRUG RESISTANCE.
          Medical guidelines recommend either tenofovir (brand name Viread) or entecavir to effective lower viral load and reduce your risk of liver damage. Please talk to your doctor, and you can review the World Health Organization’s guidelines for hepatitis B treatment with him at: http://www.who.int/hiv/pub/hepatitis/hepatitis-b-guidelines/en/
          One more note, medical guidelines recommend treatment only if you are experiencing liver damage (indicated by elevated ALT or SGPT levels) and have a high viral load. Do you have liver damage? Please check your lab tests to see if you should continue treatment.
          Good luck.

  163. Hi please suggest me I am jitrndra 28yrs WT.40kgs from India Bihar.i am suffering Hep b+ from 8 yrs. Medicine tenefovir 300 mg with cardivilol 3.125 mg 2×2 current but my LFT is not good and digestion is also.Hbv DNA 5copy.

    1. Hello: I assume you take Cardivilol for heart problems? One of its side effects, according to Web MD (http://www.webmd.com/drugs/2/drug-5574/carvedilol-oral/details/list-sideeffects) is causing liver problems. Because of this impact on your liver, you should talk to your doctor and see if there is a different heart medicine you can take that will not affect the liver.
      Also, were you prescribed antivirals because you were experiencing liver damage? And did the liver damage happen before or after you took the Cardivilol? Please see if there is an alternative drug you can take.
      Good luck.

  164. After hard work I always feel weak ,tired so easily and painful body at times.And I am on my daily antiretrovril.Testing for viral lord is expensive.

    1. Hello: I’m sorry these tests are so expensive. You may want to see your doctor to see if there is another medical condition, other than hepatitis B, that is causing the fatigue. Also, the liver enzyme test for ALT/SGPT tends to be the least expensive test and can at least tell you if your fatigue is linked to any liver damage. Good luck.

  165. hi, what do you advice if one month treatment with pegasys interferon led to a dangerous drop in white blood cells count;neutofils, etc, forcing doctor to recommend discontinuation of therapy. Looking to restart therapy with either entecavir or TAF after a 6-weeks layoff. thanks. william

    1. Hello: First, to make sure, do you have signs of liver damage? Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. If you do need treatment, either entecavir or TAF are excellent options considering interferon was not an option for you.
      Good luck.

  166. My question is that if one person infected hbv than how many chances infected other families member, if they vaccinated hbv, I vaccinated hbv my wife, how many chances she infected hbv but I vaccinated hbv my baby,waiting for cure, inshallah one day cure found………

    1. Hello: Of all diseases transmitted by direct contact with blood, hepatitis B is among the most easy to transmit because there can be a lot of virus in a small amount of blood or body fluids. Vaccination is the best tool to use to safeguard your family against hepatitis B. Make sure you baby is vaccinated immediately against hepatitis B. Good luck.

  167. Hi dr

    I always have pain under my ribs area near I think is near my liver I went dr they did ultrasound and everything shows good and every month I do blood test and my dr keep saying everything All level for liver is good I hope soon a cure come we all worried about hep b

    God bless you

    Thanks

  168. Hi, my mom has hepatitis b. Initially it was 15 IU/ml but after 8 months the blood report shows 72 IU/ml. And the docter has not suggested any medicines till now. He says its all right you dont have to take any medicines right now. And he has said to check up again after 6 months. So my mom should take medicines now or not ?? Hope for your kind response. Thank you.

    1. Hello: If the 15 IU/mL is referring to her liver enzymes (either ALT or SGPT) and it has increased to 72, that increase indicates a moderate increase in liver damage. (If that figure refers to her viral load (HBV DNA), it is minor and has no clinical significance.)
      Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for women range up to 19.
      Has her doctor measured her viral load (HBV DNA)? Also, how old is your mother and how is her overall health? Does she have any relatives with liver damage?
      Because the increase in ALT levels is not large, the doctor may want to monitor her for a few months to see if her ALT levels continue to remain elevated. If she does ever need treatment, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir.
      Keep in mind once someone starts taking antivirals, they are a long-term commitment. Antivirals work only for as long as she takes them. Good luck.

      1. My grandma die from heptitas B she was only 50 year old . II also have hepititas B. is the cure going to release soon or plz contact me. And could you tell me the closest year it going to be done thank.

        1. Hello: I am sorry to hear about your grandmother. Experts predict a cure should be developed in the next several years, and we remain optimistic. In the meantime, please eat healthy foods, avoid alcohol and cigarettes, and get monitored regularly to guard against liver damage. I hope your family has been tested for hepatitis B and vaccinated, if needed. Good luck.

      2. Hello I get tested for several times..my doctor did not recommend any medications.. I have hepa b chronic..

        1. Hello: Keep in mind that not everyone with hepatitis B requires treatment, many people live long and healthy lives with hepatitis B. Generally, medical guidelines recommend treatment only if you are experiencing liver damage. This is indicated by an ultrasound and a simple blood test for the liver enzyme ALT (also called SGPT). Our liver cells release ALT when they are damaged or die. Healthy ALT levels for men are up to 30, and for women they are up to 19. Please consult with your doctor and see what your ALT levels are to determine if you require treatment. If you ever do, there are two very effective antiviral medications that are recommended: tenofovir (Viread) and entecavir. Good luck.

          1. By body is well..but I can’t work abroad having this kind of virus hep B chronic..hoping for completely cure soon..

          2. Hello: The stigma and discrimination faced by people living with hepatitis B in certain countries is terrible, especially because it is so unjustified. We must keep fighting discrimination at all levels. Good luck.

          3. Is it all countries discriminate people w/hepa B to work abroad??i really need to work abroad to earn more money for my kids..but having this kind of virus I can’t to go Kuwait..

          4. Hello: I am sorry to hear about the unwarranted discrimination you face. It is reprehensible but some countries in Asia and the Middle East continue to think hepatitis B poses a health threat, even though it is not spread through casual contact. Countries in Europe and North America do not discriminate against people with hepatitis B. I wish you good luck.

          5. Here’s my test result can you please help me to understand this result..
            HbSag-reactive inter immunochromatography
            Anti-Hbc 0.12- Nonreactive
            Anti-Hbe 0.91-reactive
            Antigen HbeAg 0.334- nonreactive
            SGPT- 31
            Liver ultrasound impression-consider diffuse fatty infiltration of the liver..thank you

  169. Hi, please is it possible to have a slight left abdominal pain, very low viral load and yet not have any liver damage occurring, Q2. Will treatment reduce the left lower abdominal pain, if yes what kind of treatment. Thanks and good Job

    1. Hello: Normally abdominal pain is not associated with hepatitis B. There are very few sensory nerves around our liver, so we rarely feel any pain from a liver infection, which is why hepatitis B is called the silent infection. Your pain could result from a medical condition unrelated to hepatitis B. Please talk to your doctor about your symptoms. For more information on abdominal pain and hepatitis B, please read: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/
      Good luck.

  170. A cancer drug was 100 percent successful in clearing away hepatitis B infections in preclinical models for an Australian study. If researchers successfully replicate the results in human clinical trials, the drug may become the first-ever cure to the hepatitis B virus and may serve as a model for treating other viruses, such as HIV and herpes.

    ** I saw this online so how come no one talk about this ** or this did not got approve ?

    any detail you know about this dr

    thank you

  171. Hello Greeting for the day!
    This is one of my friends report.
    on 28/04/12 hbv dna 451 iu/ml
    started inhibit 0.5 ml entecavir
    31/10/12 hbv dna (target not detected)
    30/8/2013 hbv dna (target not detected)
    03/02/13 anti-hbe 0.01
    03/02/13 hbeag 0.22
    14/03/14 hbsag 1.74
    stoped medicine
    9/2/15 hbv dna 825 iu/ml
    30/11/15 hbv dna 224 iu/ml
    24/4l16 LFT normal
    4/7/16 LFT normal
    9/7/16 hbv dna 25 iu/ml
    9/7/16 electrical impendance & vcs, capillary photometry NORMAL
    2/2/2017 hbv dna 57 iu/ml

    Kindly could you please advice me according to the report. her husband is vaccinated. In market there are lots of ayurvedic clinic like patanjali (baba Ram dev) Nirogam etc. they are sayng confidently it is curable. is there any medicine to cure the hepatitis b?

    Thank you.

    1. Hello: Based on the lab reports you provided, your friend does not need any treatment. Her viral load (HBV DNA) is extremely low and her liver function tests show her liver is healthy. She has “inactive” hepatitis B and her immune system is doing a good job suppressing the infection. She still needs to be monitored every six months to one year, but she does not require treatment.
      Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      Lastly, as long as her husband is vaccinated, he is protected against infection.
      If and when your friend has children, it is very important that the newborn is vaccinated with the first dose of the hepatitis B vaccine within 12 hours of birth, and also is given HBIG (hepatitis B antibodies) if it is available.
      Good luck.

  172. Doctor, how I can reduce my sgpt, iam taking TDF 4 months, due tu treatment I gain the Wight of my body, increase 5 kg and now my Wight is 95 kg and my age is 30, and hight is 5 foot 8 inch

  173. Hi,pls I first tested for hep b pos in 2012 but did not pay attention so in December 2016 I was diagnosed again with severe flu and muscle ache and my lab result is as follows: HBsAg pos, HBeAg pos,HBcAb pos,HBeAb neg,Alt 30.70 U/I,AST 28.83 U/I and in two months time my HBeAg is neg and HBeAg is pos so pls is my result improving?

    1. Hello: It is always good news to clear or test negative for the hepatitis B “e” antigen (HBeAg) and positive for the hepatitis B “e” antibody (HBeAb or antiHBe). This means your immune system is fighting your hepatitis B infection, and you may be transitioning from an immune-tolerant stage, where your immune system tolerates the infection, to an immune active stage where your immune system is actively fighting it.
      It is important that you continue to be monitored every six to 12 months, whatever your doctor recommends, to make sure the infection does not harm your liver. In the meantime, avoid alcohol and cigarettes and eat healthy foods and practice safe sex. Good luck.

        1. Hello: There is no cure and no medication that has been found to eradicate HBsAg.
          In some lucky people, over time or after lengthy antiviral treatment, they are able to clear HBsAg.
          What you can do is eat healthy foods and avoid alcohol and cigarettes. Good luck.

  174. Hlo sir, my self nidhi .Few months ago i go for card test of hepatitus B and it was positive . Dr suggest me for DNA test for viral load. but the viral load is negative. Sir please tell me what can i do and is it possible that card test will be negative with the medicins. Even i go for OT,PT test also it was oll ok . PLease help me sir

    1. Hello: It is not unusual to have an undetectable viral load (HBV DNA) and still test positive for the hepatitis B surface antigen (HBsAg), which indicates a hepatitis B infection. The hepatitis B virus produces far more HBsAg than it needs to make up the outer “surface” of the virus. Scientists believe this excess HBsAg act as decoys, preventing our immune system from clearing out the infection.
      Please continue to be monitored for HBsAg, as it may disappear if this was an acute infection. Also, you may want to get tested for liver damage with a blood test for the liver enzymes ALT (also called SGPT). Good luck.

  175. What’s all about this drug called TXL® (CMX157) in phase 2 clinical trial??
    I heard it may be the cornerstone.
    More details please?

    1. Hello: Tenofovir exalidex (formerly called CMX157), is a new formulation of the antiviral tenofovir that reaches liver cells more effectively than the current formulation. As you noted it is Phase 2 clinical trials in hepatitis B patients. It is currently under investigation at a 100 mg dose, and the company will soon evaluate it at a 150-mg dose. Another new formulation of tenofovir, called TAF or Vemlidy, was recently approved for hepatitis B treatment by the U.S. Food and Drug Administration.
      For the latest on hepatitis B drugs in development, please visit our Drug Watch page at: http://www.hepb.org/treatment-and-management/drug-watch/
      Good luck.

    1. Hello: Livomyn or livolin is an herbal supplement, and there is no clinical proof that it protects the liver or cures hepatitis B.
      Please keep in mind that herbal remedies and supplements are not regulated so you don¹t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices which go a long way towards maintaining the health of your liver.
      Also, because your liver is healthy with an ALT of 24, you do not appear to need treatment at this time. Good luck.

  176. I didn’t notice this great blog, hepb org, or really care about the curation of Hep B until my girlfriend broke up with me because I’m a carrier. I cared less before because I have been feeling normal and my blood test and ultrasound reports are all good, ALT enzyme is in the safe range and virus load is low. And I’m only 26.

    So many people in my big family are carriers. I don’t know how we got infected. (We were all born in a really poor rural remote area in east Asia.

    I have been avoiding alcohol. In some events like business meals and socials, the most I got is only 1-2 bottle of light beer (once a month).

    I’m really hoping the cure for hep B. I know currently available medicine are only effective in controlling the virus volume and patients who started taking medicine need to take it forever!!!

    My questions are:

    1. If my wife is immune/vaccinated, and I’m a carrier, will our babies have hep B? What are the possibilities of yes and no? (I can manage to have zero contact with the babies.)

    2. How do I stay posted with Heb B org? I mean to get real-time notifications when there’s a progress in the drug research?

    3. What’s the latest update on the drug research at the Institute and Arbutus Biopharma, who the Institute licensed the Hep B inhibiting molecule?

    4. Besides the Institute, are there any other organizations out there have promising cure developments?

    Thank you very much,

    1. Hello: I’m glad you found us! Here are answers to your questions?
      1. If my wife is immune/vaccinated, and I’m a carrier, will our babies have hep B? What are the possibilities of yes and no? (I can manage to have zero contact with the babies.) You pose no infection threat to your children as long as they are immediately vaccinated within 12 hours of birth, and then receive the following two doses. Don’t be afraid, hepatitis B is spread through direct contact with infectious blood and body fluids. As long as you practice universal precautions and don’t share nail clippers, razors or personal jewelry, you will not infect them.
      2. How do I stay posted with Heb B org? I mean to get real-time notifications when there’s a progress in the drug research? Check our Drug Watch page at http://www.hepb.org/treatment-and-management/drug-watch/ regularly to find the latest, and check back with our website, facebook page and blog and learn the latest.
      3. What’s the latest update on the drug research at the Institute and Arbutus Biopharma, who the Institute licensed the Hep B inhibiting molecule? Check the Drug Watch page.
      4. Besides the Institute, are there any other organizations out there have promising cure developments? There are several firms around the world working to find a cure for hepatitis B. You can find their websites on our Drug Watch page.
      Good luck!

      1. Thanks for the quick response. Just three quick follow-up questions:
        On Drug Watch website, different drugs are in various phases: Preclinical, phase I and Phase II.
        1. How many phases are there before a drug is made available to the public?

        2. How long will each phase take?

        3. In the column “US Status” in the table on Drug Watch website, how do I know the drug is a cure for Hep B, meaning cure Hep B completely/permanently, or it’s just another drug to control the Heb B virus?

        Thanks,

        1. Hello: Good questions. Usually a clinical trials has three stages, but they can take a long period of time, and the length of time while they are in clinical trials is not predictable.
          Right now, there is no absolute cure for hepatitis B. Research firms are striving to find a combination of treatments that prevent the virus from replicating, strengthen the immune system, and even reduce the amount of hepatitis B surface antigen (HBsAg) that will result in a true cure — that will eradicate all of the virus from the liver. Keep checking the Drug Watch page http://www.hepb.org/treatment-and-management/drug-watch/ as we will update the list of treatments as they enter clinical trials. Thank you.

    1. Hello: That is excellent news. Testing positive for the hepatitis B surface antibody (HBsAb) means your immune system has successfully cleared the infection. Good luck.

  177. I am glad to receive your reply. Also I would like to thank you from bottom of my heart.
    I do agree with you regarding the herbal remedies but one of my friend also had hepatities b and his viral load was 18,000000.and he started to have tenivir 500 mg after the 1 year his dna is negative but HbsAg is positive then he started to have cow urine now his HbsAg is negative. His Dr. could not believe and happy then he asked him to repeat the HbsAg its again came Negative. so even my friend also started to have cow urine.
    Is there any possibilities to find the medicine to cure hep B? If yes with in how many month/ year we can hear and save millions of people? I hope actually we hope all the scientist and doctors are working hard to done it.
    If you could advice about the diet and exercise it would me appreciated.

    Thank you.

    1. Hello: Tenofovir, the antiviral he took, is very effective at quickly lowering viral load (HBV DNA) and reducing his risk of liver damage. There is no clinical evidence that cow urine is an effective treatment for hepatitis B.
      Many people around the world are working hard to find a cure for hepatitis B, we remain optimistic.
      The best advice is to eat lead a healthy lifestyle and eat healthy, low-fat foods with lots of fruits and vegetables, and of course avoid alcohol and cigarettes. Good luck.

  178. My internationally adopted HepB daughter has been in the immune tolerant phase until this year (she is 15 years old now). She is followed annually by an excellent pediatric hepatologist. This year, for the first time, her AST/ALT are elevated to 88/192 respectively. The tests were just repeated a month later – results not in yet. Her viral load decreased over the last year. I am guessing this is her body attempting to clear the virus? Is she a good candidate for treatment, or is it better to hold off and test again in three months?

    1. Hello: As you noted, it very well could be that she is moving out of the immune-tolerant stage, and her immune system is starting to fight the infection by attacking the infected liver cells (which of course increases her ALT levels) and is hopefully generating antibodies. What is her viral load (HBV DNA) and does she still test positive for the hepatitis B “e” antigen (HBeAg)?
      Unless there are prolonged signs of continued liver damage (elevated ALT levels) doctors may be reluctant to start her on antiviral treatment because of her young age. They may be hoping that her immune system will continue to do its job in clearing the infection. Also, depending on her HBV genotype, she may be a good candidate for pegylated interferon treatment if her liver damage continues. While interferon requires a weekly injection and causes some side effects, you take it for a finite period and it can result in permanent loss of HBeAg and even HBsAg in some patients. Good luck.

  179. Hello: Jay d congratulations! could you please share which medicine you had? And question for Dr. which is the best Tenovir or entecavier? shall we to GYM?

    1. Hello: Either tenofovir or entecavir is recommended. However, if in the past you were treated with lamivudine and/or adefovir (Hepsera), it is recommended that you are treated with tenofovir, which is effective against those drug-resistant virus. Good luck.

  180. Hello. Im Sarah from Philillines. My boyfriend’s family has Hepa B, they discovered it last month, January 2017. My boyfriend is 22 years old. Can he take vaccine at his age? because he didint take any vaccine for hepa eversince. Is there age limit for hepa vaccine? and how long the vaccine will take? I hope you will read my post because we dont know what to do. we afraid to consult doctor. we want a remedy. Thankyou in advance.

    1. Hello: If he knows someone in his immediate family has hepatitis B, he should immediately get tested for both the hepatitis B surface antigen (HBsAg) and the surface antibody (anti-HBs). This will show if he is currently infected or if he was exposed to the virus in the past and was able to clear the infection.
      If he tests negative for both the hepatitis B surface antigen and antibody, he needs to be immediately vaccinated. If he is already infected, the vaccine will do nothing for him, and if he was infected in the past and cleared the virus, then he does not need to be vaccinated.
      If he is infected, he needs to find out so he can be monitored.
      Last piece of advice: Have you been vaccinated? Please get tested and vaccinated if you have not been already. Good luck.

  181. My husband test result
    HbSag non-reactive
    Anti-Hbs <2.00 and here's my lab. test result
    HbSag-reactive inter immunochromatography
    Anti-hbc 0.12- nonreactive
    Anti-hbe 0.91- reactive
    Antigen HbeAg 0.33-nonreactive
    SGPT-31
    Liver ultrasound impression consider diffuse fatty infiltration of the liver..

    1. Hello: Because your husband does not test positive for the hepatitis B surface antigen (HBsAg), he is not considered infected with hepatitis B.
      Your SGPT (liver enzyme) is moderately above 19, which is considered healthy for women. However, every lab has its own “healthy” range so yours may not be above average.
      As you may know, a combination of fatty liver and hepatitis B can accelerate liver damage over time. Believe me, I know this is hard to do, but try to lead a healthy lifestyle with exercise and healthy eating. And of course avoid alcohol and cigarettes, and keep getting monitored regularly. Good luck.

  182. Hi

    How long it will develop the present status of seeking thecomplete treatment of this desease..any precise years expected??? Thank you hope will develop it as soon as possible.

  183. Hello Doctor,
    Here are my test results:
    Age: 37 male, HBV effected by bird
    HbsAg: 1830 IU/ml
    HbeAg: Negative
    Anti-Hbe: 18.5 NCU/mL
    Anti-HbS: Negative
    Anti-HBc: 76 NCU/mL
    HBV-DNA: 4.02 10^6 Cps/mL
    AST (GOT): 59 U/L
    ALT (GPT):107 U/L
    GGT: 43 U/L
    I never take any treatment agaist HBV.
    Should I take a treatment for now? If yes tenofovir of inteferon ?
    Thank you.

    1. Hello: Is this the first time you have been tested for hepatitis B? If this is the first time, you should get tested again in six months to find out if this is a chronic infection (meaning you have probably been infected since childhood and your infection is long-term) or if you have resolved the infection and had a short-term, acute infection.
      Your current tests show you are infected with hepatitis B (as indicated by the positive test for the hepatitis B surface antigen (HBsAg).
      Your liver enzyme test (ALT/SGPT) is about three-times above normal, indicating you are experiencing some liver damage. I am not sure I can translate your viral load (HBV DNA) correctly.
      Please continue to be monitored and if your doctor determines you have a chronic infection and your ALT levels continue to be elevated in the months ahead, you should get treatment.
      The antiviral tenofovir (Viread) will quickly lower your viral load and reduce your risk of liver damage. However, antivirals work for only as long as you take them, so this medication is a long-term commitment that may last for several years.
      Pegylated interferon is administered in a weekly injection that is taken for up to one year. It causes some flu-like side effects, however it does stimulate the immune system and if you have the right HBV genotype, it does succeed in about 30 percent of cases.
      Please talk to your doctor to see if after continued monitoring you still require treatment, which is the best option for you. Also, have you been tested for hepatitis D?
      Good luck.

      1. I have been infected since childhood and I have been monitored for HBV for several years.
        In 2014, the HBV-DNA is 500000 copies/mL and in the end of 2016 it is about 4000000 copies/ml (about eight times larger of 2014 results). My Doctor indeed said that I need a treatment. I took tenoforvir for three months and the HBV-DNA now is undetectable and Alt 25, Ast 24. I continues taking tenoforvir as required.
        What I wonder is that now my Anti-Hbe is quite high, 18.3 NCU/mL (three years before it is about 13.5 NCU/mL). Does that say that my immune system is fighting well with HBV?
        I am in HbeAg negative class, is Anti-Hbe a good thing to look at?
        I haven’t been tested for hepatitis D (but C – negative).
        Thank you.

        1. Also, I intended that after one year of taking tenoforvir, I will start using interferon. Is this a good approach?
          Which HBV genotype has succeed in about 30 percent of cases? Should I test for HBV genotypes now?

          1. Hello: Research shows that patients with hepatitis B genotypes A and B tend to respond better to pegylated interferon than patients with genotypes C and D. Interferon works only if your immune system is already fighting the infection — indicated by elevated ALT/SGPT levels. In people with genotypes A and B, it is successful about 30 to 40 percent of the time in spurring loss of the hepatitis B “e” antigen (HBeAg) and development of “e” antibodies. If you are able to get genotyping done, I would especially if you are considering pegylated interferon treatment. Good luck.

        2. Hello: Yes, it is good to test positive for the hepatitis B “e” antibody (anti-HBe) because it shows your immune system is trying to fight the infection and has already “knocked off” or eradicated the “e” antigen. Your viral load should be lower now as a result. Good luck.

          1. I forgot to say that in my case HbeAg is negative Before treatment and also anti-Hbe is 18.3 NCU/mL before treatment as well.
            If a person is HbeAg positive, then it is crucial to look at anti-Hbe. But in my case, HbeAg is negative Before treatment ,is this anti-Hbe still good thing to look at?
            Thank you so much.

          2. Hi: Your “e” antibody (anti-HBe) should remain positive throughout treatment. Monitor your ALT/SGPT and also your HBsAg levels if that diagnostic tool is available. Good luck.

          3. I learned that in my case, a treatment is successful only if HbsAg is lost and Anti-Hbs is developed. Tenoforvir seems to never archive Hbsag loss. How about pegylated interferon ?
            I am a negative Hbeag person and taking a daily tenofovir, should I take at the same time pegylated interferon to archive Hbasg loss?

          4. Hello: The jury is still out about the benefits — or even the most effective sequence — of combination antiviral and interferon treatment. There are a small percentage of people who do lose HBsAg after long-term tenofovir (only) treatment, and the new tenofovir formulation TAF may be found to yield even higher HBsAg seroconversion rates. If you can, have your doctor measure your HBsAg levels during treatment (read http://www.hepb.org/blog/doctors-get-new-tool-improve-hepatitis-b-treatment-monitoring/) to assess if your HBsAg levels are declining over the course of treatment. I don’t know where you live, but it just was approved in the U.S., and was already used commonly in Europe and Asia. Good luck.

          5. Thanks. Should I take TAF instead of tenofovir? Could you show me the research revealed that TAF may be found to yield even higher HBsAg seroconversion rates?

          6. Hello: So far it hasn’t been proven to improve HBsAg seroconversion rates, but it lowers ALT/SGPT levels faster than conventional tenofovir, so everyone expects and hopes it may be more effective in other ways too. It was just approved in the US, Japan and Europe, so there’s not a lot of data. To research it, search TAF tenofovir alafenamide Vemlidy. Good luck.

  184. Hello, I just got my result today :

    Result Normal Range
    GOT / GOT (AST) 48 U/L * 0 – 32
    GPT / GPT (ALT) 31 U/L 10 – 35
    GGT / Gamma GT 12 U/L 5 – 36

    Should I concern about this result ? I always had normal result, it was surprising for me seeing AST incresed.

    1. Hello: Your liver enzyme levels are slightly elevated. Healthy ALT/SGPT levels range up to about 19 for women and 30 for men. Individual lab values for normal can run a little higher, as do yours. Are you male or female? If you’re a woman, your values are a bit high. Have you been measuring your viral load (HBV DNA)? Has that changed?
      You may want to increase the frequency when you are monitored, so you’re tested at least every six months.
      Also, do you drink alcohol or have fatty liver? That can also cause increases in liver enzymes. Good luck.

  185. Please ignore the first email address

    1. Please per the result below, what is my chances of surviving till the cure is found?
    2. Which is the viral load? (HBV DNA copies & Hepatitis B virus DNA), and which one is dangerios when it increases?
    3. These ‘re the druges (Simepar and tenofovir) i was given and how effect are they because i still feel some pain?
    test done on 28/11/2016
    S-BILIRUBIN (Total) 15 umol/L
    S-BILIRUBIN conjugated 5 umol/L
    S-ALKALINE PHOSPHATASE 53 IU/L
    S-g-GLUTAMYL TRANSFERASE 34 IU/L
    S-ALT (GPT) 37 IU/L
    S-AST (GOT) 41 IU/L
    S-TOTAL PROTEIN 84 g/L
    S-ALBDMIN 50 g/L
    HBV DNA copies __3184 cp/mL
    Hepatitis B virus DNA 547IU/ml

    1. Hello: I don’t know your age, gender or overall health, but your results are good, and your chances of a long, healthy life are very good as long as you take care of yourself, and of course avoid alcohol and cigarettes and fatty liver.
      Healthy liver enzymes (ALT/SGPT) levels for women are up to 19 and for men up to 30. Yours are a bit high, but each individual lab has it’s own healthy range, so 38 may be healthy.
      Your viral load at 547 IU/mL is also quite low.
      Medical guidelines recommend treatment only if your were experiencing liver damage (with elevated ALT/SGPT levels) and a fairly high viral load. Was your ALT/SGPT higher before you started treatment?
      I am not familiar with simepar — what is that prescribed for?
      Tenofovir is an excellent antiviral for hepatitis B treatment.
      Because the liver has very few sensory nerves around it, it’s unusual for people with hepatitis B to experience abdominal pain (see: http://www.hepb.org/blog/when-is-that-pain-hep-b-related-and-when-is-it-something-else/). I recommend you talk to your doctor about any pain or discomfort you are having.
      Good luck.

  186. Hi I want to use vemlidy medicine but in market it is available in 10mg each medicine .but the medicine which I have seen it was 25 mg.can u guide me can I take it as 10mg in a day means will 10mg a day would effect or I should use 2 n half medicine to make it 25mg?

    1. Hello: I am not familiar with Vemlidy (TAF or tenofovir alafenamide) being available at a 10 mg dose. As you noted, the drug as approved by the U.S. FDA for hepatitis B treatment is at the 25 mg-strength. If all you have is 10 mg, you should take 2 1/2 pills daily with food, but please talk to your liver specialist about this. Good luck.

  187. Thank You for your answer. I am a women,I don’t drink alcohol and I don’t have a fatty liver. During this period I have started the gym and did it every day for two hours. Today I got the result of HVB DNA and it was < 20 Ul/ml where the limit of quantification is upper 20, I am not in active phase and there is no replication.

    1. Hello: That is unusual to have elevated liver enzymes while such low viral load. Continue to be monitored while continuing your healthy lifestyle and of course avoiding alcohol and cigarettes. Good luck.

  188. I am a male in my late 30s and discovered I had Hepatitis B in 2008.I did LFT which indicated my liver was fine. Afterwards I took Lamivudine for about 2 months and much later Livoline for about 3 months just to fortify my liver. Knowing that entecavir and tenofovir was approved by WHO,could I start taking tenofovir,say for 6 months, as I might be one of the lucky people the treatment would clear HBsAg for, rather than keep waiting for a lucky break in the search for a cure?

    1. Hello: WHO and other medical guidelines do not recommend treatment unless you are experiencing liver damage, indicated by elevated liver enzymes (ALT or SGPT) or by an ultrasound. If your liver is fine, you do not need treatment.
      When people have liver damage, doctors prescribe one of two antivirals — either tenofovir or entecavir. Lamivudine is no longer recommended because it causes a high rate of drug resistance.
      Antivirals work for only as long as you take them, they won’t clear your virus in a few months. Most people end up taking them for several years, and only a small percentage of them ever clear hepatitis B, and often only after a long period of treatment and a decline in HBsAG.
      Please review your hepatitis B test results and ALT/SGPT levels with your doctor. Perhaps simply getting monitored regularly, along with eating healthy foods and avoiding alcohol and cigarettes, is what you need to do right now. Good luck.

    1. Hello: This lab result shows your hepatitis B infection is not harming your liver. Our liver cells release the enzyme ALT (also called SGPT) into the blood when they are damaged. Healthy ALT/SGPT levels are up to 19 in women and 30 in men. Good luck.

  189. Hi i lives in pakistan.i visited more than 3 doctrs,two doctor’s says no need to start treatment yet and two doctors says to start treatment,they made me confused whether to start treatment or not.please suggest me what should i do?
    Can i come to USA for my treatmen and can you take oppointment for me?

  190. Hi admin I’ve been on treatment for a year taking truvada and lamivudine while I’m hiv negative so I’ve discovered that the doctor who putted me on this treatment shouldn’t since I’m negative so i went to other hospital n a doctor there changed me to only tdf, so can’t i experience any sides effects n flares plz help

    1. Hello: I cannot address the best treatment for HIV-hepatitis B coinfection, but tenofovir (TDF) is very effective against hepatitis B. It was originally developed as an HIV drug.
      Lamivudine is no longer recommend for hepatitis B because it causes a high rate of drug resistance. Good luck.

  191. Sir. I am recently found out that I have Hepatitis B. When I test the -Hepatitis B Virus(HBV DNA) Quantitative, the result found out HBV DNA>3.8IU/ml. The ultrasound result shows liver is normal. The doctor prescribe me to eat LIV 52-HB for three months. Sir I am please your kindness to advice and give some suggestions which will be more effective to antiviral of HB. And also pray to inspire you to find the perfect curable medicine very soon. Thank you.

    1. Hello: Medical guidelines recommend treatment only if you are experiencing liver damage, which is indicated by elevated liver enzymes (ALT/SGPT) or a liver ultrasound, and you have a high viral load. It appears you have a low viral load, do you know what your ALT/SGPT levels are? Is LIV 52-HB the herbal supplement called livolin? If it is, we cannot recommend it because there is no clinical proof that it cures hepatitis B or protects the liver.
      The National Institutes for Health has published fact sheets on various herbal supplements, the home page is at: https://nccih.nih.gov/health/herbsataglance.htm
      Please keep in mind that herbal remedies and supplements are not regulated so you don’t really know for sure what is in them, and that the contents could change from one bottle to the next.
      The other problem with herbal remedies in general is there is typically NO evidence (no clinical trials or data) to back up a claim for a cure, which is why the NIH fact sheets are so valuable.
      We at the foundation cannot recommend any claims for a cure that are not backed by scientific data or endorsed by the U.S. Food and Drug Administration. Sometimes, supplements and remedies can harm the liver more than help it.
      I would encourage you to discuss the use of these herbal remedies or supplements with your liver specialist, along with learning more about your HBV and liver health. I would also encourage you to focus adopting healthy lifestyle choices (including avoiding alcohol and cigarettes), which go a long way towards maintaining the health of your liver. Good luck.

  192. With dis result of mine, i was told is not contactable, that even someone touches my blood.
    Hepatitis B’s ag =positive
    Hepatitis b envelope A.g =negative
    Hepatitis b core Ab =positive
    Hepatitis b Ab-negative.. Does it mean if i have unprotected sex with my partner, she’s not going to contact it from me, i have plaeced her on vaccine, she has already taken the first shot, and second will be next 7 days and last shot 21 days, immediatly after d last shot can sex her without condom?.. Thanks always.

    1. Hello: Whenever anyone tests positive for the hepatitis B surface antigen (HBsAg), they are contagious and can spread hepatitis B through unprotected sex and direct contact with your blood and body fluids (semen).
      Before you have sex without a barrier or condom, you need to wait. About one or two months after your partner receives the third vaccine shot, she should have her hepatitis B surface antibodies (anti-HBs or HBsAb) tested. If she has at least 10 mIU/mL of surface antibodies, then she is protected against hepatitis B and you can have unprotected sex without fear of infecting her. Until then, you must use a condom. Good luck.

  193. Hepatitis B patients living in Africa are living with much fear. There is no antirvital drug here. All they give us here is Livomyn which is not a potent in treating hep B. Please tell the hep B organisation to do something to help Africans.

    We are been left out of these antiviral…
    We are dying…

    1. Hello: I am sorry to hear of your predicament. There are a number of organizations in Africa working to improve immunization, testing and treatment of people with hepatitis B. What country do you live in? We collaborate with a number of organizations in Africa, and you can look at the World Hepatitis Alliance’s website at http://www.worldhepatitisalliance.org and find if it has member organizations in your country. Good luck.

  194. Sir I am Anilkumar from GULBARGA karnataka (India) I am serving defence services I was carrying chronic hep b from 2007 last year Dec tasting report hbsag +, hbeag + and Alt – 32 IU/L, hbv dna 4500 c/my and ultrasound and fibre scan reports are normal but Dr’s no any thing advise me and nothing start any medicine there fore sir please help me what can I do thanking u sir.

    1. Hello: Your doctor is correct, medical guidelines do not recommend treatment unless you have signs of liver damage, indicated by an elevated ALT level, or from ultrasound findings. Both your ALT and ultrasound are normal, and your final load (HBV DNA) is low, so your hepatitis B is “inactive” and requires no treatment. Keep getting monitored and of course avoid alcohol and cigarettes, eat healthy foods, practice safe sex and make sure all of your family members have been tested for hepatitis B and vaccinated if needed. Good luck.

  195. How long can a person with chronic Hep B live?also visited the links you gave for voluntary clinical trials but couldn’t find anything

  196. Hello doctor my mom tested hep b cames positive and they (hospital) sent us a post which is says that she is positive and has old hepatis B and i don’t know what they mean old but my mom was feeling sickness all of her life we came from a ware town country no goverment,
    But what do they mean old do they found out a liver problem when they are saying old? We did first test and they made another appointment after 2 weeks,

    How can we know if my moms liver is damaged?