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CDC Recommendation for Infant Vaccination

The Hepatitis B Foundation has prepared a summary of the CDC recommendation for vaccinating infants. Read the web linkFull Report.

CDC Recommendations for HBV Vaccination of Infants

First Dose: Birth to two months. Children whose mothers are hepatitis B surface antigen positive or whose hepatitis B surface antigen status is unknown should get this dose within 12 hours of birth.

All infants should receive the first dose of hepatitis B vaccine soon after birth and before hospital discharge; the first dose may also be given by age 2 months if the infant's mother is hepatitis B surface antigen negative. Only monovalent hepatitis B vaccine can be used for the birth dose. Monovalent or combination vaccine containing Hep B may be used to complete the series; four doses of vaccine may be administered if combination vaccine is used.

Infants born to hepatitis B surface antigen positive mothers should receive hepatitis B vaccine and 0.5 milliliters of hepatitis B immune globulin (HBIG) within 12 hours of birth at separate sites.

Infants born to mothers whose hepatitis B surface antigen status is unknown should receive the first dose of the hepatitis B vaccine series within 12 hours of birth. Maternal blood should be drawn at the time of delivery to determine the mother's hepatitis B surface antigen status; if the test is positive, the infant should receive H BIG as soon as possible (no later than one week).

Second Dose: One to four months, but at least 4 weeks after the first dose, except for Hib-containing vaccine which cannot be administered before age 6 weeks.

For infants born to hepatitis B surface antigen positive mothers, the second dose is recommended at age 1-2 months and the vaccination series should be completed (third or fourth dose) at age 6 months.

Third Dose: Six to 18 months, but at least 16 weeks after the first dose and at least 8 weeks after the second dose. The last dose in the vaccination series (third or fourth dose) should not be administered before age 6 months.

For infants born to hepatitis B surface antigen positive mothers, the vaccination series should be completed (third or fourth dose) at age 6 months.

Source: Centers of Disease Control web linkRecommended Childhood and Adolescent Immunization Schedule, United States, 2003.

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