급성 B형 간염 감염: 새로운 B형 간염 감염.
Adefovir (Hepsera): B형 간염에 먹는 약으로서 FDA가 2002년 9월 승인.
Alanine Aminotransferase (ALT): 간세포 파손 여부를 검사하는데 사용하는 중요한 간효소.
모든 만성 B형 간염 환자들의 정기 모니터링에 ALT 수준 검사도 포함되었다; 환자가 과연 치료요법으로 혜택을
볼 것인지 또는 현재 받고 있는 치료와 효과를 알아보는데도 이 검사를 사용한다.
Alpha-fetoprotein (AFP): 임신 중 또는 암세표가 존재할 때 혈액으로 분비되는 단백질. 이
수준이 높으면 간암이 진행되고 있다는 표시일 수 있기 때문에 의사들은 이 검사를 주문한다.
항체: 항체는 일반적으로 감염을 방지한다. 백신을 맞거나 B형 간염 바이러스 등에 감염되면 그 반응으로 항체가
복수(腹水): 간이 기능을 상실하거나, 간경변 또는 간암이 생겼을 때 배에 대량으로 차는 액체. 이러한 증세는
즉각적인 치료가 요구된다.
무증상: 증상이 뚜렷이 나타나지 않는 감염이나 병을 말한다. B형이나 C형 간염을 갖고 있는 많은 환자들이
새로 감염되었거나 또는 만성 감염 중에 증상을 느끼지 못한다; 이러한 현상을 무증상으로 본다.
만성 B형 간염 감염: 검사 결과 6개월 이상 B형 간염 양성으로 나타난 사람은 만성 B형 간염 환자로 본다.
간경변: 간 조직에 심한 흉터를 유발하여 간 기능 상실로 이어지는 심각한 간 손상.
임상 실험: 신약의 안전성을 시험해 보기 위하여 환자들이 자원 참여하는 제어된 연구.
e-항체 (HBeAb 또는 anti-HBe): e-항원에 반응으로 생성되는 항체로서(아래 참조) B형 간염에서
회복한 환자나 만성 감염된 환자들에게서 발견된다. 하지만 B형 간염 바이러스로부터 환자를 보호하지 않는다.
e-항체 (HBeAg): B형 간염 바이러스가 만든 단백질. 이 혈액검사는 만성 감염과 관련이 되었고 활성
B형 간염이 있는지를 알려준다.
뇌증: 간질환이 심해지면 심각한 뇌기능 손상이 올 수 있다. 흔한 증상으로 혼동, 방향감각 상실, 불면증 등이
있으며 나중에는 혼수 상태로 빠질 수 있다.
엔터카비르: 만성 B형 간염용 경구제로서 2005년 4월 FDA 승인을 받았음.
오류 양성: 오류 때문에 양성으로 나타난 검사 결과.
섬유증 (간): 간이 부어서 섬유조직이 자라는 현상을 말함. 섬유증은 더욱 심각한 간질환인 간경변으로 발전할
식품의약국 (FDA): 인체에 사용될 의약품을 승인하는 미연방정부 조직.
위장병학: 소화기관의 기능과 장애를 집중적으로 연구하는 의학 분야로서 식도, 위, 췌장, 장, 간이 여기에
간염: "간에 염증"을 말하며 이러한 염증은 바이러스, 박테리아, 외상, 약부작용 또는
알코올 중독 등 여러 원인으로 생길 수 있다. 바이러스로 간에 염증이 생겼을 때 바이러스성 간염(viral hepatitis)
A형 간염: A형 간염 바이러스(HAV)로 생기는 급성 감염 . 대부분의 환자들은 6주에서 10주면 완전히
회복한다. A형 간염은 주로 배설물과 오염된 음식이나 물로 옮긴다. HAV를 예방하는 안전한 백신이 있다.
B형 간염: B형 간염 바이러스(HBV) 때문에 생긴다. 감염된 성인들 중 약 10%는 만성 B형 간염으로
발전한다.: HBV에 감염된 여성이 분만한 신생아들 중 90%는 만성 감염으로 발전한다. 주로, 혈액, 무방비
성교, 주사바늘 공유를 통하여 옮기며, 또한 분만 중 감염된 산모가 신생아에게 옮긴다. HBV를 예방하는 안전한
C형 간염: C형 간염 바이러 스(HCV) 때문에 생긴다. 감염된 성인들 중 약 85%는 만성 C형 감염으로
발전한다. 주로 감염된 혈액을 통하여 옮긴다. 백신이 없다.
D형 간염: D형 간염 바이러 스(HDV) 때문에 생긴다. 이 바이러스는 이미 B형 간염에 걸린 환자들에게만
감염된다. 백신이 없다.
HBIG (Hepatitis B immuneglobulin): 환자가 B형 바이러스에 노출된 직후(24시간
내)에 주는 약. 예를 들어, HBV에 감염된 여성이 낳은 신생아는 즉시 HBIG를 맞고 그 후 12시간 안에
일차 HBV 백신을 맞아야 만성 감염을 예방할 수 있다. 그밖에 다른 환자들은 B형 간염 바이러스에 노출된 후
24시간에 맞아야 한다.
B형 간염 혈액 패널: B형 간염에 감염되었는지 확인하기 위하여 사용하는 흔한 혈액검사로서, B형 간염 표면
항원(HBsAg), B형 간염 표면 항체 (HBsAb) 그리고 B형 간염 코어 항체(HBcAb)로 구성되었다.
B형 간염 혈액검사:
1. B형 간염 표면 항원(HBsAg): 이 단백질은 감염 여부를 알아보기 위하여 쓰인다. 혈액 검사 결과가
양성이면 B형 간염 바이러스가 있다는 증거이다.
2. B형 간염 표면 항체(HBsAb 또는 anti-HBs): 이 항체는 예방접종을 맞거나 실제 B형 간염에서
회복할 때 생긴다. 검사 결과가 양성이면 환자가 B형 간염에서 보호받고 있다는 증거이다.
3. B형 간염 코어 항체(HBcAb 또는 anti-HBc): 과거와 현재 감염 여부를 알려준다. 이 항체는
HBV로부터 환자를 보호하지 않는다. 이 검사는 주로 혈액은행에서 기증된 혈액을 가려낼 때 사용한다. 검사 결과가
양성이면 B형 간염 바이러스에 노출되었다는 증거이지만, B형 간염 상태 여부는 HBsAg와 HBsAb(위 참조)를
통해서만 확실히 알 수 있다.
B형 간염 DNA: 혈액 안에 바이러스가 얼마나 있는가를 측정하는 혈액검사. B형 간염 치료가 얼마나 효과가
있는가 평가하는데 사용된다.
B형 간염 e-항체 (HBeAb 또는 anti-HBe): e-항원에 반응으로 생성되는 항체로서(아래 참조)
B형 간염에서 회복한 환자나 만성 감염된 환자들에게서 발견된다. 하지만 B형 간염 바이러스로부터 환자를 보호하지
B형 간염 e-항원(HBeAg): B형 간염 바이러스가 만든 단백질 이 혈액검사는 만성 감염과 관련이 되었고,
활성 B형 간염이 있는지를 알려준다.
간세포 암종(HCC): 간암을 말한다. 전세계 모든 간암의 발병 원인의 80%가 만성 B형 간염이다.
간전문의: 간질환 연구와 치료를 전문으로 하는 의사. 만성 B형 간염이 있는 환자들은 "간전문의"를
찾아 보는 것이 좋다.
간학: 간질환 연구에 집중하는 의학분야. 위장학에서 더 세분화된 분야.
IgG anti-HBc: 과거에 또는 현재 B형 간염에 감염되었는지 여부를 알려준다. 이 혈액검사와 HBsAg가
모두 양성이면(즉 IgM anti-HBc 결핍), 만성 HBV에 감염되었다는 증거이다.
IgM anti-HBc: 과거에 또는 현재 B형 간염에 감염되었는지 여부를 알려준다. 테스트 결과가 양성이면
6개월 이내에 감염되었다는 증거이다 .
면역체계: 박테리아, 바이러스 및 그밖에 다른 유해 성분에서 몸을 보호해 주는 방위체계.
인터페론: 감염에서 보호하기 위하여 몸이 만들어 내는 단백질. 간세포를 포함하여 여러 종류의 세포들이 인터페론을
만들어 낸다. 인터페론은 또한 만성 B형 간염을 치료하기 위하여 생명공학을 통하여 합성하여 만들어 낼 수 있다.
Interferon Alpha-2b (Intron A): 몸에서 생성된 감염과 싸우는 면역 물질을 흉내내어
만든 약. 이 약은 만성 B형 감염 치료제로서 1991년 최초로 승인되었다. 1주에 서너번 주사로 주입된다.
이 약은 성인과 2세 이상의 어린이용 둘다 있다.
Peg Interferon Alfa-2a (Pegasys): 또 다른 인터페론 약이다. 2005년 5월에 승인된
이 약은 1주에 한 번 약은 C형 간염 치료제로 승인받았지만 만성 B형 간염 치료용으로는 현재까지 임상실험 중이다.
1주에 한 번만 주사로 맞으면 되고 인터페론 알파보다 부작용이 적은 것으로 알려졌다.
황달: 피부와 눈이 노랗게 되는 병. 황달은 여러 신체 장애로 생길 수 있는데, 바이러스형 간염, 알코올 중독,
독극물, 적혈구 세포의 비정상적인 분해 또는 담낭 질환 등이 그러한 예들이다. 이러한 증세는 즉각적인 치료가
Lamivudine (Epivir-HBV, Zeffix, Heptodin): B형 간염 바이러스의 재생을 늦추거나
중단시키는 약. 만성 B형 간염 치료제로서 1998년에 두번 째로 승인받았다. 매일 먹는 약으로서 성인과 어린이용
간: 몸 안에서 가장 큰 장기. 간은 단백질, 콜레스테롤, 담즙과 응고 물질을 생성하는 등 여러 기능들을 갖고
있다. 또한 당분을 저장하고, 탄수화물, 지방, 단백질을 분해한다. 간은 주 에너지 원천이다.
간 조직검사: 특수한 바늘을 사용하여 간세포를 약간 제거하는 작업. 조직을 현미경으로 관찰하여 간에 손상이
간기능 검사(LFT): ATL 수준 검사 등 간기능 평가에 사용되는 일련의 혈액검사들을 말한다. 이 검사들은
간질환은 물론 만성 B형 간염을 진단하는데도 사용된다.
Polymerase DNA: B형 간염 바이러스 재생에 필수적으로 필요한 효소. HBV 치료에 사용되는 대부분의
항바이러스 약들은 DNA 폴리머레이스를 방해하여 바이러스가 재생되는 것을 막는다.
백신: 면역체계를 자극하여 특정 질환에 걸리는 것을 예방하는 항체들을 생성하는 약. A형 간염 백신, B형
간염 백신이 있고 A형과 B형 간염 모두를 예방하는 혼용 백신이 있다.
바이러스성 간염: 간만 공격하는 바이러스 때문에 생긴 간염증. A형, B형, C형, D형, E형, F형, G형
바이러스 부하: B형 간염과 같이 혈중에 존재하는 실제 바이러스의 양의 측정(B형 간염 DNA 참조).
Acute Hepatitis Infection: A new, suddenly
occurring infection. It occurs with a person’s first exposure
to the hepatitis B virus.
Adefovir dipivoxil (Hepsera): An oral nucleoside
analogue drug that interferes with the replication of the hepatitis
B virus (e.g. it can slow down or stop the virus from reproducing).
It was approved for chronic hepatitis B in September 2002.
Albumin: A protein made in the liver that assists
in maintaining blood volume in the arteries and veins. If the
liver is damaged, then the albumin can drop to very low levels,
which may cause fluid to leak into the tissues from the blood
vessels, resulting in edema or swelling. In acute liver failure,
there is an accumulation of fluid in the abdomen that is known
Alpha-fetoprotein (AFP): A protein secreted
into the blood during pregnancy or when cancer cells are present.
Increased levels may indicate the development of liver cancer,
which is why the simple AFP blood test is included in the regular
monitoring of those which chronic HBV.
Antibody: A protein molecule produced by the
immune system in response to a foreign body, such as the hepatitis
B virus. Antibodies can be produced in response to a vaccine
or to a natural infection. They circulate in the blood to protect
against future infections.
Anti-HCV (antibody to hepatitis C virus):
The antibody produced against the hepatitis C virus (HCV). Its
presence in the bloodstream often indicates HCV infection. This
antibody has not been shown to protect people against hepatitis
Antigen: A protein on the surface of a virus,
bacteria or cell that can stimulate the immune system to produce
antibodies as a defense mechanism.
Ascites: A large, abnormal accumulation of
fluid in the abdomen that can occur due to liver failure, cirrhosis
and liver cancer. This condition requires immediate medical attention.
Asymptomatic: Refers to infection or disease
without signs of illness. Many patients with hepatitis B or C
do not have any symptoms during a new or chronic infection; they
are considered to be asymptomatic.
Bilirubin: The liver usually clears this end
product of hemoglobin (the portion of the red blood cell that
carries oxygen in the blood) when it normally breaks down. If
the liver is damaged and bilirubin accumulates in the blood,
a person can become jaundiced (yellowed eyes and skin).
Bloodborne Pathogens: Substances present in
the blood that can cause infection or disease. Hepatitis B and
hepatitis C viruses are bloodborne pathogens since they are spread
through blood and can cause a liver infection.
Carcinoma: A new growth or malignant tumor
that can occur throughout the body (e.g. hepatocellular carcinoma
refers to liver cancer).
Centers for Disease Control and Prevention (CDC): This
federal organization is concerned with the prevention and control
of communicable diseases such as hepatitis B and C. It conducts
extensive research and provides information about public health
Chronic Hepatitis B Infection: A patient who
tests positive for the hepatitis B virus for more than 6 months
is considered to have a chronic hepatitis B infection.
Cirrhosis: A serious liver condition characterized
by irreversible scarring of the liver that can lead to liver
failure and death. Alcohol and chronic viral hepatitis (such
as chronic hepatitis B and C) can cause continuous inflammation
of the liver, which can lead to excess scar formation or fibrosis.
Scarring results in the loss of liver cells and impairs liver
Clinical Trials: Carefully controlled studies
that are conducted in humans who volunteer to test the effectiveness
and safety of new drugs, medical products or techniques. All
drugs in the United States undergo three phases of clinical trials
before being approved for general use.
Clotting Factors: Proteins made in the liver
that are important in maintaining normal blood clotting. Disruption
in the blood's ability to clot may indicate that the liver is
not creating enough clotting factors. A severe shortage in clotting
factors may indicate that a liver transplant is needed.
Complete Blood Count (CBC): A test that measures
the number of red blood cells, white blood cells, the amount
of hemoglobin, hematocrit, and platelets. Low white blood cell
and platelet counts may indicate liver scarring.
Complications: New medical problems that arise
while treating existing ones.
DNA Polymerase: An enzyme essential to the
replication of the hepatitis B virus. Most of the current antiviral
drugs used against HBV interfere with the DNA polymerase in order
to stop the virus from reproducing.
Decompensated Cirrhosis: A late-stage cirrhosis
accompanied by abnormal blood tests and other complications.
At this stage of the disease, evaluation for liver transplant
becomes an option.
E-Antibody (HBeAb or anti-HBe): Produced by
the immune system temporarily during acute HBV infection or consistently
during or after a burst in viral replication. Spontaneous conversion
from e-antigen to e-antibody (a change known as "seroconversion")
is a predictor of long-term clearance of HBV in patients undergoing
Encephalopathy: Serious brain function abnormalities
experienced by some patients with advanced liver disease. Symptoms
most commonly include confusion, disorientation, insomnia, and
may progress to a coma.
Entecavir: An oral nucloeside analogue drug
that interferes with the replication of the hepatitis B virus
(e.g. it can slow down or stop the virus from reproducing). It
was the third oral drug approved for chronic hepatitis B in April
Enzymes: Naturally occurring chemical substances
in the human body that help a chemical reaction take place.
Epidemiology: A field of medical science that
studies the incidence, distribution, and control of disease in
a population. This information is often used to determine causes
and methods of controlling diseases.
False-Positive: A test result that mistakenly
gives a positive reading.
Fatty Liver: Refers to a condition where fat
accumulates in liver cells. This accumulation of fat does not
generally cause liver damage, but it needs to be monitored. It
is detected by liver biopsy.
Fibrosis (hepatic): Growth of fibrous tissue
in the liver where there is usually liver cell damage or destruction.
Fibrosis can lead to cirrhosis, an even more serious liver disease.
Food and Drug Administration (FDA): A federal
organization charged with protecting the public health. It establishes
safety and effectiveness guidelines for healthcare products such
as the drugs that are used to treat hepatitis B and C.
Gastroenterology: The field of medicine that
focuses on the function and disorders of the GI system, which
includes the esophagus, stomach, pancreas, intestines, and liver.
Genome: Refers to the genetic material of
an organism such as a human or a virus.
Genotype: A pattern of genetic information
that is unique to an individual or group. The hepatitis B virus
has a pattern of genetic information unique to itself. Doctors
may determine the genotype to help decide the best treatment.
Currently, there are seven known genotypes for hepatitis B; however,
its significance is not well established for clinical use. Hepatitis
C treatment can be based on genotype.
Hepatitis: Refers to “inflammation of the
liver”, which can be caused by many things such as viruses, bacterial
infections, trauma, adverse drug reactions, or alcoholism. Inflammation
of the liver caused by viruses is called “viral hepatitis”. There
are many different viruses that attack the liver:
Hepatitis A: Formerly called “infectious hepatitis”,
it is caused by the hepatitis A virus (HAV) and is an acute infection.
There is no chronic infection. Most patients recover completely
within 6 to 10 weeks. Hepatitis A is spread mainly via feces
and contaminated food and water. There is a safe vaccine for
Hepatitis B: Formerly called “serum hepatitis”,
it is caused by the hepatitis B virus (HBV). Approximately 10%
of infected adults progress to chronic hepatitis B; 90% of newborns
born to HBV infected women develop chronic infections; and young
children have a 30-50% chance of developing a chronic infection.
It is spread primarily through blood, unprotected sex, shared
needles, and from an infected mother to her newborn during the
delivery process. There is a safe vaccine for HBV.
Hepatitis C: Formerly known as “non-A, non-B
hepatitis”, it is caused by the hepatitis C virus (HCV). Approximately
85% of infected adults will develop chronic hepatitis C infections.
It is spread through infected blood, primarily in those who use
illicit street drugs and those who received blood transfusions
prior to1992 (the first year that a blood test for HCV became
available for screening the blood supply). There is no vaccine.
Hepatitis D: Known as “delta hepatitis”, it
is caused by the hepatitis D virus (HDV). This virus can only
co-infect patients who are already infected with hepatitis B.
Hepatitis D infection is rare in the United States. It occurs
primarily in recipients of multiple blood transfusions, including
patients with hemophilia or those undergoing renal dialysis,
and among people who share contaminated needles. There is no
Hepatitis E: Also referred to as “enterically
transmitted non-A, non-B hepatitis”, it is caused by the hepatitis
E virus (HEV). It is spread through fecal contamination of water;
occurs primarily in developing countries; and is found rarely
in the United States. Hepatitis E infection results in an acute
infection much like hepatitis A; it does not cause chronic infection.
There is no vaccine.
Hepatitis F: Only a handful of cases have been
reported from France with subsequent experimental transmission
to primates. The virology, epidemiology and clinical importance
of the hepatitis F virus are uncertain. There is no commercial
test nor is there a vaccine.
Hepatitis G: The hepatitis G virus (also called
hepatitis GB virus or HGBV-C) is a distant relative of the hepatitis
C virus. It appears to be transmitted through transfusions (one
to two percent of US blood donors have HGV RNA detectable in
their serum). Its role in acute and chronic hepatitis remains
unclear. Recent studies suggest that the virus may not even replicate
in the liver. At the present time, HGV does not appear to be
an important cause of clinical liver disease. There is no commercial
test nor is there a vaccine.
Hepatitis B Blood Panel: There are three common
hepatitis B tests that make up the Hepatitis B Blood Panel. This
is a simple test that requires only one blood sample, which can
be obtained during an office visit to the doctor.
B Surface Antigen (HBsAg): The surface protein of
the hepatitis B virus that is used as a marker to detect infection.
If this blood test is positive, then the hepatitis B virus
B Surface Antibody (HBsAb or anti-HBs): The antibody
formed in response to the surface protein of the hepatitis
B virus. It can be produced in response to vaccination or recovery
from an actual hepatitis B infection. If this test is positive,
then the immune system has successfully developed a protective
antibody against the hepatitis B virus that provides long-term
B Core Antibody (HBcAb or anti-HBc): This antibody
only refers to a part of the virus itself; it does not provide
any protection or immunity against HBV. This test is often
used by blood banks to screen blood donations. A positive test
indicates a person may have been exposed to the hepatitis B
virus, but the result can only be confirmed in relationship
to the above two tests.
HBeAg: A marker of a high degree of HBV infectivity,
it correlates with a high level of HBV replication. It is primarily
used to help determine the clinical management of patients with
chronic HBV infection.
Hepatitis B Immune Globulin (HBIG): A medication
that is given as a “post-exposure” treatment to prevent hepatitis
B. This means that HBIG is given after a person has been exposed
to potentially infected blood or infected bodily fluids, which
can include but is not limited to - contact with blood or through
a needlestick, infants born to infected women, and through sexual
contact or close household contact with an infected person. HBIG
is often used as a post-liver transplant treatment.
HBV-DNA: A marker of viral replication. It
correlates well with infectivity. It is used to assess and monitor
the treatment of patients with chronic HBV infection.
Hepatocellular Carcinoma (HCC): A malignant
tumor of the liver, otherwise known as liver cancer. Chronic
hepatitis B and C infections may increase the risk of developing
Hepatocyte: A liver cell.
Hepatologist: A doctor who specializes in
the study and treatment of liver disease. Ideally, patients with
chronic hepatitis B or C should see a “hepatologist”.
Hepatology: The field of medicine that focuses
on diseases of the liver. It is a sub-specialty within gastroenterology.
Histology: The field of medicine that studies
tissue under the microscope. Histological evaluations of liver
biopsy samples are helpful in the diagnosis and monitoring of
possible liver damage in chronic HBV and HCV carriers.
IgG anti-HBc: A subclass of the hepatitis B
core antibody (HBcAb or anti-HBc) is a marker of past or current
infection with HBV. If it and HBsAg are both positive (in the
absence of IgM anti-HBc), this indicates chronic HBV infection.
IgM anti-HBc: A subclass of the hepatitis B
core antibody (HBcAb or anti-HBc). Positivity indicates recent
infection with HBV (less than 6 months). Its presence indicates
Immune System: The body’s defense system against
invasion by foreign bodies such as bacteria, viruses, fungi,
parasites, and malignant cells.
Immunology: The branch of medicine that studies
the immune system, immunity, and allergies.
Infection: The results of the presence of
harmful microorganisms in the body. Infections can be acute (sudden)
or chronic (persistent).
Injection: A method of administering drugs
or nutrients into the body using a needle.
- Intramuscular (IM): into muscle tissue.
- Intravenous (IV): into a vein.
- Subcutaneous (SQ): beneath the skin.
Interferon: A protein that is produced by the
body to protect against infection. Many different cells including
liver cells produce natural interferon. Interferon also can be
manufactured artificially through biotechnology for the treatment
of chronic hepatitis B and C.
Interferon Alpha-2b (Intron A): A drug that
mimics naturally occurring “interferon”, which is an infection-fighting
immune substance produced by the body. It is self-administered
at least three times a week by injection. This was the first
drug approved for chronic hepatitis B in 1991. Available for
both adults and children greater than 2 years old.
Investigational Drug: A new drug that is undergoing
clinical trials to prove its effectiveness and safety (see clinical
Jaundice: A condition characterized by yellowing
of the skin and eyes. Jaundice is a symptom of many disorders,
which can include viral hepatitis, alcoholism, poisoning, and
abnormal breakdown of red blood cells or gallbladder disease.
This symptom requires immediate medical attention.
Lamivudine (Epivir-HBV, Zeffix, Heptodin): An
oral nucleoside analogue drug that interferes with the replication
of the hepatitis B virus (e.g. it can slow down or stop the virus
from reproducing). It was the second drug approved for chronic
hepatitis B in December 1998. Available for both adults and children.
Liver: The largest glandular organ in the
body. The liver has many functions that include, but are not
limited to the production of protein and cholesterol, the production
of bile and clotting factors, the storage of sugar in the form
of glycogen, and the breakdown of carbohydrates, fats, and proteins.
The liver also breaks down and excretes many medications.
Liver Biopsy: The removal of a small piece
of tissue from the liver using a special needle. The tissue is
examined under a microscope to look for the presence of inflammation
or liver damage (see histology).
Liver Enzymes: Proteins that catalyze chemical
reactions needed for bodily functions. Levels of certain enzymes,
such as ALT and AST are higher when the liver is injured, as
they leak into the bloodstream when the cell is injured or destroyed.
Liver Function Tests (LFT’s): Refers to a
group of blood tests used to evaluate the function of the liver.
The tests can be used to diagnose and monitor chronic viral hepatitis
as well as other liver diseases. The two most common tests include
the following liver enzymes:
- Aspartate Aminotransferase (AST): An enzyme
that is released into the blood by the liver and other tissues
or organs. It is generally used as a marker for liver or biliary
- Alanine Aminotransferase (ALT): An enzyme
that is released into the blood by damaged liver cell. It is
used as a marker for liver cell damage. The ALT test is considered
to be a more accurate reflection of liver inflammation than
AST because other organs such as the heart can also produce
AST. (e.g. the level of AST will increase on a blood test during
a heart attack). ALT levels are included in the regular monitoring
of all chronic hepatitis B patients; this test can also useful
in deciding whether a patient would benefit from therapy or
evaluating the effectiveness of an ongoing treatment.
Needlestick: Refers to an accidental puncture
of the skin while handling hypodermic needles or syringes. This
is most common among health care providers such as physicians,
nurses, and emergency response personnel.
Non-Responders: Patients who do not respond
to therapy or a vaccine within a specific period.
Patient Compliance: Patients who correctly
follow all the instructions about a course of therapy as directed
by their physician are considered to be “compliant” with a treatment
protocol (see protocol below).
PCR (polymerase chain reaction): A highly
sophisticated scientific method of detecting the presence of
hepatitis B virus DNA or hepatitis C virus RNA in the blood.
This test can be conducted on the same sample of blood obtained
with the hepatitis B panel of blood tests; no extra doctor’s
visit is needed.
Peg Interferon Alfa-2a (Pegasys): A pegylated
interferon drug that mimics naturally occurring “interferon”,
which is an infection-fighting immune substance produced by the
body. It is self-administered once a week by injection and seems
to have fewer side effects than the interferon alpha. Approved
for treatment of chronic hepatitis B in May 2005.
Percutaneous: Passage or absorption of substances
into the body through unbroken skin.
Perinatal Transmission (vertical transmission): Transmission
of an infectious disease, such as hepatitis B, from mother to
newborn. All pregnant women should be tested for hepatitis B
since newborns have a 90% chance of becoming chronically infected
if they do not receive the first dose of hepatitis B vaccine
and a single dose of HBIG within 12 hours after delivery. The
infant will also need additional doses of hepatitis B vaccine
at one and six months of age to ensure a complete immune response.
Persistent: A disease or other medical condition
that returns or continues over a long time.
Platelets: Cells that are produced in the
bone marrow. Platelets control bleeding by causing the blood
to clot. The liver produces the clotting factors involved in
this process. If the liver is damaged, then clotting will also
Post-Transfusion Hepatitis: Liver inflammation,
or hepatitis, that occurs when the body reacts unfavorably to
a blood transfusion. This is now rare in the United States due
to careful blood screening procedures.
Protein: A substance made of a string of amino
acids. Proteins are the “building blocks” of the human body.
Protocol: A detailed plan of a scientific
experiment or medical treatment. A specific step-by-step procedure
is used in clinical trials to test new drugs and treatments for
diseases such as chronic hepatitis B.
Recombinant DNA: Genetic material that has
been altered and recombined in the laboratory by cutting up DNA
molecules and splicing together specific DNA fragments. Many
drugs, including the hepatitis B vaccines, are produced using
recombinant DNA methods.
Reconstitution: The process of adding liquid
to a dry powder to make a new solution. Prescription drugs that
are given by injection are often provided as a dry powder, which
must be reconstituted (e.g. liquid must be added) before it can
Recreational Drugs (illicit drug use): Illegal
drugs, such as marijuana, crack, cocaine, and heroin. People
who use these drugs have a much greater risk of acquiring a hepatitis
B or C infection as a result of sharing needles or engaging in
other behaviors that increase their risk of exposure to infected
Relapse: The return (or recurrence) of symptoms
of a disease after a period of improvement.
Remission: A period of time during which all
or some of the symptoms of a disease have disappeared or decreased
in severity. Remission may occur spontaneously or as a result
of medical treatment.
Retreatment: Treatment that is restarted after
a patient has suffered a relapse or has not responded to treatment
the first time.
Risk Factors: Refers to behaviors and conditions
that increase the possibility of an individual developing a disease.
Smoking is a risk factor for lung cancer. Jobs that expose a
person to blood or the use of illegal drugs are risk factors
for acquiring a hepatitis B or C infection.
Screening: Testing blood samples or blood
donations for the presence of disease. Before blood donations
are accepted, they are screened for hepatitis B, hepatitis C,
and HIV/AIDS and other bloodborne pathogens.
Self-Administration: Therapy, such as interferon
injections, that patients give to themselves rather than having
it done by a health care provider.
Seroconversion: A change in status from antigen
positive/antibody negative to antigen negative/antibody positive.
For example, seroconversion of e-antigen positive to e-antibody
positive indicates a significant decrease in the amount of hepatitis
B virus. Seroconversion of hepatitis B surface antigen positive/surface
antibody negative to surface antigen negative/surface antibody
positive connotes being "cured" of a chronic HBV infection
since the virus has been cleared from the liver and bloodstream.
Serology: Refers to the study of serum (the
clear portion of a body fluid) for its antibody content. When
a person is exposed to a microorganism, such as the hepatitis
B or C virus, the body produces specific antibodies against it.
In laboratory testing, the antibodies react with antigens in
specific ways that can be used to confirm the identity of the
microorganism, however, this test is not used to diagnose a current
Spleen: An organ located in the left upper
abdomen that removes old red blood cell and other blood cells
from circulation. The spleen can enlarge in a person who has
STD (sexually transmitted disease): A disease
that is transmitted through sexual contact.
Sustained Response: A response to therapy
that continues over a long time period. For example, a patient
treated for chronic hepatitis B or C who remains free of the
virus for at least 6 months after stopping treatment is considered
to have a sustained response to therapy.
Symptom: Any change in the body or its functions,
as perceived by the patient, which could indicate the presence
T-Cells: A type of white blood cells that
are involved in rejecting foreign tissue, regulating immunity,
and controlling the production of antibodies to fight infection.
Therapy: Treatment of a disease.
Transaminases: Refers to SGOT or SGPT, which
are older terms for the ALT and AST amino transferases (see liver
Transfusion: The introduction of whole blood
or components of blood (such as plasma, platelets) from one person
Transmission: The way or method by which a
disease can be spread.
Vaccine: A medication that stimulates the
production of antibodies to protect against a specific disease.
There is a hepatitis A vaccine, hepatitis B vaccine, and a combination
vaccine that provides protection against both hepatitis A and
B at the same time.
Variceal Bleeding: Abnormal bleeding from
ruptured blood vessels in the esophagus that results from severely
impaired blood flow through the liver. Patients with advanced
cirrhosis are at greatest risk for this complication. This is
a life-threatening emergency and requires immediate medical attention.
Viral hepatitis: Inflammation of the liver
caused by viruses that specifically attack the liver: hepatitis
A, B, C, D, E, F, and G viruses.
Viral Load: Measurement of the actual amount
of virus in the bloodstream such as hepatitis B and C.
Viremia: Refers to the presence or amount
of a given virus in the bloodstream.
Virus: A tiny microorganism, smaller than
bacteria, which can invade the body and cause disease. A virus
can reproduce itself exactly or mutate and make small changes.
The ability of a virus to change slightly in each infected person
is why treatment of viral diseases is so difficult.