10. What is the progression of untreated chronic HBV?

This is the background of the clinical situation: you get the acute infection which ranges from mild infection from people who don’t know they had it to more severe actually acute infections. There are a few people who get hepatitis B acutely and just die. We have done over the years many liver transplants of people who presented with this fulminant hepatic failure meaning they got hepatitis B and for whatever reason in their body, it just destroyed their whole liver and they needed a liver transplant. On the other hand, many people don’t even know they have the infection and there are others that are just transiently ill. Then there are the ones that go on to more severe chronic liver disease, fibrosis, cirrhosis. As the scar tissue overtakes the liver, you get liver failure, cancer, and death.