14. Are there treatment options for advanced liver damage due to chronic HBV infection?
I think this diagram allows an overall picture
of hepatitis B progression. You start with the acute infection and go
into the chronic infection. Generally thirty percent of chronically
infected individuals will go on to cirrhosis. Cirrhosis leads to liver failure. Patients who get cirrhosis of their liver,
twenty-three percent of these patients within five years basically die
of liver failure and development of liver cancer. The graph shows that HBV is the sixth
leading cause of liver transplantation in the United States at the
moment and its rising very rapidly. One of the former problems with liver
transplantation in hepatitis B was that the hepatitis B came back in
the new liver because the virus settled in other cells in the body and
reappeared in the liver. But we’ve overcome that problem now and we
can successfully transplant people with hepatitis B liver failure
because we have new drugs to suppress the virus in the new
liver and the patients with hepatitis B work out
extremely well and are much more successful than the hepatitis C
patients in terms of liver transplantation.
13. What are the consequences of chronic HBV infection?
15. How do the hepatitis B therapies work?