9. How does liver cancer develop from HBV?
Hepatitis B is sort of a double whammy when it
comes to liver cancer. In hepatitis C, you can’t get liver cancer
until you get cirrhosis because what happens is you get the scar
tissue as a result of the inflammation and then the liver cells are
sort of trying desperately to re-grow and as they try to re-grow, they lose their
control mechanism and they take off like crazy and develop and become
cancer in hepatitis C and in hepatitis B and cirrhosis. But in addition, hepatitis B, because it’s a
DNA virus, can on its own right unleash development of
cancer modify the DNA and the liver cells and cause
the patient to develop cancer without going through the stage of
cirrhosis. So you have this double pronged tendency to
liver cancer. Its not uncommon to see a 32-year old Asian
person present with liver cancer who has no evidence of cirrhosis and
in a sense never sick a day of life had no idea he had liver disease until he
got a pain on his right side and was diagnosed with cancer. This is not true of other situations because
for the most part in the world, hepatitis C and other reasons,
alcohol, any other reasons, the cirrhosis comes first and the liver
cancer comes afterwards as an aberration of the cirrhosis. But in this case, you get a lot of these
young people who just having had the virus embedded in their own
DNA their own DNA and liver cells gets modified
to develop cancer.
8. What is and what causes cirrhosis of the liver?
10. What is the progression of untreated chronic HBV?