35. What is the treatment algorithm for patients with HBeAg negative compensated disease?

What about e-Negative? First we look at the DNA. If it is low, but here we use 10 to the fourth instead of 10 to the fifth , we don’t treat, these are probably inactive carriers. If the DNA is 10 to the fourth or higher, we look at the ALT. Now here, I would consider more strongly a biopsy because these people are more likely to have active disease and we would like to define that. It’s easier if the ALT is elevated- then treat. Now here, adefovir is probably preferred, because as I said earlier, you have to use long-term therapy, so you probably want to use a drug that has a lower resistance rate.